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Volumn 14, Issue 1, 2000, Pages 59-72

Ribozyme as an approach for growth suppression of human pancreatic cancer

Author keywords

Gene modulation; K ras oncogene; Pancreatic cancer; Ribozyme (catalytic RNA); Transfection; Vector

Indexed keywords

RIBOZYME;

EID: 0034022169     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:14:1:59     Document Type: Article
Times cited : (23)

References (73)
  • 2
    • 0029365320 scopus 로고
    • Application of ribozymes to cancer gene therapy
    • 2. Kashani-Sabet, M. and Scanlon, K. J. (1995) Application of ribozymes to cancer gene therapy. Cancer Gene Ther. 2, 213-221.
    • (1995) Cancer Gene Ther. , vol.2 , pp. 213-221
    • Kashani-Sabet, M.1    Scanlon, K.J.2
  • 3
    • 0029042615 scopus 로고
    • Ribozymes as human therapeutic agents
    • 3. Christoffersen, R. E. and Mar, J. J. (1995) Ribozymes as human therapeutic agents. J. Med. Chem. 38, 2023-2037.
    • (1995) J. Med. Chem. , vol.38 , pp. 2023-2037
    • Christoffersen, R.E.1    Mar, J.J.2
  • 4
    • 0028062148 scopus 로고
    • Control of oncogene expression by antisense nucleic acids
    • 4. Helene, C. (1994) Control of oncogene expression by antisense nucleic acids. Eur. J. Cancer, 30A, 1721-1726.
    • (1994) Eur. J. Cancer , vol.30 A , pp. 1721-1726
    • Helene, C.1
  • 5
    • 0027175360 scopus 로고
    • Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral ansisense K-ras construct
    • 5. Georges, R. N., Mukhopadhyay, T., Zhang, Y., Yen, N., and Roth, J.A. (1993) Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral ansisense K-ras construct. Cancer Res. 53, 1743-1746.
    • (1993) Cancer Res. , vol.53 , pp. 1743-1746
    • Georges, R.N.1    Mukhopadhyay, T.2    Zhang, Y.3    Yen, N.4    Roth, J.A.5
  • 6
    • 0027759997 scopus 로고
    • Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer inhibits expression of the malignant phenotype
    • 6. Zhang, Y., Mukhopadhyay, T., Donehower, L. A., Georges, R. N., and Roth, J.A. (1993) Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer inhibits expression of the malignant phenotype. Hum. Gene Ther. 4, 451-460.
    • (1993) Hum. Gene Ther. , vol.4 , pp. 451-460
    • Zhang, Y.1    Mukhopadhyay, T.2    Donehower, L.A.3    Georges, R.N.4    Roth, J.A.5
  • 7
    • 0029262020 scopus 로고
    • Ansisense approach to cancer gene therapy
    • 7. Mercola, D. and Cohen, J. S. (1995) Ansisense approach to cancer gene therapy. Cancer Gene Ther. 2, 47-59.
    • (1995) Cancer Gene Ther. , vol.2 , pp. 47-59
    • Mercola, D.1    Cohen, J.S.2
  • 8
    • 0028186873 scopus 로고
    • Antisense catalytic RNAs as therapeutic agents
    • 8. Castanotto, D., Rossi, J. J., and Sarver, N. (1994) Antisense catalytic RNAs as therapeutic agents. Adv. Pharmacol. 25, 289-317.
    • (1994) Adv. Pharmacol. , vol.25 , pp. 289-317
    • Castanotto, D.1    Rossi, J.J.2    Sarver, N.3
  • 13
    • 0032521822 scopus 로고    scopus 로고
    • Ribozymes as therapeutic agents: Are we getting closer?
    • 13. Scanlon, K. J. and Kashani-Sabet, M. (1998) Ribozymes as therapeutic agents: Are we getting closer? J. Natl. Cancer Inst. 90, 558-559.
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 558-559
    • Scanlon, K.J.1    Kashani-Sabet, M.2
  • 14
    • 0030668865 scopus 로고    scopus 로고
    • HER-2/neu is rate-limiting for ovarian cancer growth. Conditional depletion of HER-2/ neu by ribozyme targeting
    • 14. Juhl, H., Downing, S. G., Wellstein, A., and Czubayko, F. (1997) HER-2/neu is rate-limiting for ovarian cancer growth. Conditional depletion of HER-2/ neu by ribozyme targeting. J. Biol. Chem. 272, 29482-29486.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29482-29486
    • Juhl, H.1    Downing, S.G.2    Wellstein, A.3    Czubayko, F.4
  • 16
    • 0029758509 scopus 로고    scopus 로고
    • Use of an anti-ras ribozyme to alter the malignant phenotype of a human bladder cancer cell line
    • 16. Eastham, J. A. and Ahlering, T. E. ( 1996) Use of an anti-ras ribozyme to alter the malignant phenotype of a human bladder cancer cell line. J. Urol. 156, 1186-1188.
    • (1996) J. Urol. , vol.156 , pp. 1186-1188
    • Eastham, J.A.1    Ahlering, T.E.2
  • 17
    • 0030056108 scopus 로고    scopus 로고
    • Investigating and improving the specificity of ribozyme directed against the bcr-abl translocation
    • Leukemia 10, 1676 (erratum)
    • 17. James, H., Millis, K., and Gibson, I. (1996) Investigating and improving the specificity of ribozyme directed against the bcr-abl translocation. Leukemia 10, 1054-1064; Leukemia 10, 1676 (erratum).
    • (1996) Leukemia , vol.10 , pp. 1054-1064
    • James, H.1    Millis, K.2    Gibson, I.3
  • 23
    • 0025872121 scopus 로고
    • Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein
    • 23. Scanlon, K. J., Jiao, L., Funato, T., Wang, W., Tone, T., Rossi, J.J., and Kashani-Sabet, M. (1991) Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothionein. Proc. Natl. Acad Sci. USA 88, 10591-10595.
    • (1991) Proc. Natl. Acad Sci. USA , vol.88 , pp. 10591-10595
    • Scanlon, K.J.1    Jiao, L.2    Funato, T.3    Wang, W.4    Tone, T.5    Rossi, J.J.6    Kashani-Sabet, M.7
  • 28
    • 0028347648 scopus 로고
    • Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme
    • 28. Kashani-Sabet, M., Funato, T., Florenes, V. A., Fodstad, O., and Scanlon, K. J. (1994) Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme. Cancer Res. 54, 900-902.
    • (1994) Cancer Res. , vol.54 , pp. 900-902
    • Kashani-Sabet, M.1    Funato, T.2    Florenes, V.A.3    Fodstad, O.4    Scanlon, K.J.5
  • 29
    • 0028110360 scopus 로고
    • Ribozyme-mediated reversal of the multidrug-resistant phenotype
    • 29. Scanlon, K. J., Ishida, H., and Kashani-Sabet, M. (1994) Ribozyme-mediated reversal of the multidrug-resistant phenotype. Proc. Natl. Acad. Sci. USA 91, 11123-11127.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11123-11127
    • Scanlon, K.J.1    Ishida, H.2    Kashani-Sabet, M.3
  • 30
    • 0029069106 scopus 로고
    • Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme
    • 30. Feng, M., Cabrera, G., Deshane, J., Scanlon, K. J., and Curiel, D. T. (1995) Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme. Cancer Res. 55, 2024-2028.
    • (1995) Cancer Res. , vol.55 , pp. 2024-2028
    • Feng, M.1    Cabrera, G.2    Deshane, J.3    Scanlon, K.J.4    Curiel, D.T.5
  • 31
    • 0029866954 scopus 로고    scopus 로고
    • Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes
    • 31. Ohta, Y., Kijima, H., Kashani-Sabet, M., and Scanlon, K. J. (1996) Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes. J. Invest. Dermatol. 106, 275-280.
    • (1996) J. Invest. Dermatol. , vol.106 , pp. 275-280
    • Ohta, Y.1    Kijima, H.2    Kashani-Sabet, M.3    Scanlon, K.J.4
  • 34
    • 0024633224 scopus 로고
    • Carcinoma of the pancreas: A clinicopathologic study of 96 cases with immunohistochemical observations
    • 34. Yamaguchi, K. and Enjoji, E. (1989) Carcinoma of the pancreas: a clinicopathologic study of 96 cases with immunohistochemical observations. Jap. J. Clin. Oncol. 19, 14-22.
    • (1989) Jap. J. Clin. Oncol. , vol.19 , pp. 14-22
    • Yamaguchi, K.1    Enjoji, E.2
  • 35
    • 0026655958 scopus 로고
    • Improvement of pancreatic cancer treatment from the japanese experience in the 1980's
    • 35. Ozaki, H. (1992) Improvement of pancreatic cancer treatment from the Japanese experience in the 1980's. Int. J. Pancreatol. 12, 5-9.
    • (1992) Int. J. Pancreatol. , vol.12 , pp. 5-9
    • Ozaki, H.1
  • 36
    • 0025650881 scopus 로고
    • Overview of chemotherapy for pancreatic cancer
    • 36. Arbuck, S. G. (1990) Overview of chemotherapy for pancreatic cancer. Int. J. Pancreatol., 7, 209-222.
    • (1990) Int. J. Pancreatol. , vol.7 , pp. 209-222
    • Arbuck, S.G.1
  • 37
    • 0025637087 scopus 로고
    • Overview of pancreatic cancer, 1989
    • 37. Cohn, I. Jr. (1990) Overview of pancreatic cancer, 1989. Int. J. Pancreatol. 7, 1-11.
    • (1990) Int. J. Pancreatol. , vol.7 , pp. 1-11
    • Cohn I., Jr.1
  • 38
    • 0027422247 scopus 로고
    • The pathway to signal achievement
    • 38. Egan, S. E. and Weinberg, R. A. (1993) The pathway to signal achievement. Nature 365, 781-783.
    • (1993) Nature , vol.365 , pp. 781-783
    • Egan, S.E.1    Weinberg, R.A.2
  • 39
    • 0021320926 scopus 로고
    • Expression of cellular oncogenes in human malignancies
    • 39. Slamon, D. J., deKernion, J. B., Verma, I. M., and Cline, M. J. (1984) Expression of cellular oncogenes in human malignancies. Science 224, 256-262.
    • (1984) Science , vol.224 , pp. 256-262
    • Slamon, D.J.1    DeKernion, J.B.2    Verma, I.M.3    Cline, M.J.4
  • 41
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • 41. Bos, J. L. (1989) ras oncogenes in human cancer: A review. Cancer Res. 49, 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 42
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • 42. Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N., and Perucho, M. (1988) Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 45
    • 0024786508 scopus 로고
    • Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients
    • 45. Mariyama, M., Kishi, K., Nakamura, K, Obata, H., and Nishimura, S. (1989) Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients. Jpn. J. Cancer Res. 80, 622-626.
    • (1989) Jpn. J. Cancer Res. , vol.80 , pp. 622-626
    • Mariyama, M.1    Kishi, K.2    Nakamura, K.3    Obata, H.4    Nishimura, S.5
  • 46
    • 0025196234 scopus 로고
    • Analysis of ras gene mutations in biliary and pancreatic tumors by polyperase chain reaction and direct sequencing
    • 46. Tada, M., Yokosuka, O., Omata, M., Ohto, M., and Isono, K. (1990) Analysis of ras gene mutations in biliary and pancreatic tumors by polyperase chain reaction and direct sequencing. Cancer, 66, 930-935.
    • (1990) Cancer , vol.66 , pp. 930-935
    • Tada, M.1    Yokosuka, O.2    Omata, M.3    Ohto, M.4    Isono, K.5
  • 47
    • 0025306220 scopus 로고
    • Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese
    • 47. Nagata, Y., Abe, M., Motoshima, K., Nakayama, E., and Shiku, H. (1990) Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese. Jpn. J. Cancer Res. 81, 135-140.
    • (1990) Jpn. J. Cancer Res. , vol.81 , pp. 135-140
    • Nagata, Y.1    Abe, M.2    Motoshima, K.3    Nakayama, E.4    Shiku, H.5
  • 48
    • 0027502624 scopus 로고
    • Frequent c-K-ras oncogene activation in mucous cell hyperplasia of pancreas suffering from chronic inflammation
    • 48. Yanagisawa, A., Ohtake, K., Ohashi, K., Hori, M., Kitagawa, T., Sugano, H., and Kato, Y. (1993) Frequent c-K-ras oncogene activation in mucous cell hyperplasia of pancreas suffering from chronic inflammation. Cancer Res. 53, 953-956.
    • (1993) Cancer Res. , vol.53 , pp. 953-956
    • Yanagisawa, A.1    Ohtake, K.2    Ohashi, K.3    Hori, M.4    Kitagawa, T.5    Sugano, H.6    Kato, Y.7
  • 51
    • 0022261138 scopus 로고
    • Evolution of the functional human b-actin gene and its multi-pseudo gene family: Conservation of noncoding regions and chromosomal dispersion of psuedogenes
    • 51. Ng, S-Y., Gunning, P., Eddy, R., Ponte, P., Leavitt, J., Show, T., and Kedes, L. (1985) Evolution of the functional human b-actin gene and its multi-pseudo gene family: Conservation of noncoding regions and chromosomal dispersion of psuedogenes. Mol. Cell. Biol. 5, 2720-2732.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2720-2732
    • Ng, S.-Y.1    Gunning, P.2    Eddy, R.3    Ponte, P.4    Leavitt, J.5    Show, T.6    Kedes, L.7
  • 52
    • 0000046089 scopus 로고
    • A human β-actin expression vector system directs high-level accumulation of antisense transcripts
    • 52. Gunning, P., Leavitt, J., Muscat, G., Ng, S-Y., and Kedes, L. (1987) A human β-actin expression vector system directs high-level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA 84, 4831-4835.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 4831-4835
    • Gunning, P.1    Leavitt, J.2    Muscat, G.3    Ng, S.-Y.4    Kedes, L.5
  • 53
    • 0027104146 scopus 로고
    • A simplified procedure for hybridization of RNA blots
    • 53. Lee, F-J. S., Moss, J., and Lin, L-W. (1992) A simplified procedure for hybridization of RNA blots. Biotechniques 13, 130-132.
    • (1992) Biotechniques , vol.13 , pp. 130-132
    • Lee, F.-J.S.1    Moss, J.2    Lin, L.-W.3
  • 54
    • 0016740911 scopus 로고
    • Agar plate culture and Lederberg-style replica plating of mammalian cells
    • 54. Kuroki, T. (1978) Agar plate culture and Lederberg-style replica plating of mammalian cells. Methods Cell Biol. 9, 157-178.
    • (1978) Methods Cell Biol. , vol.9 , pp. 157-178
    • Kuroki, T.1
  • 56
    • 0032577925 scopus 로고    scopus 로고
    • Hammerhead ribozymes against γ-glutamyleysteine synthetase mRNA down-regulate intracellular glutathione concentration of mouse islet cells
    • 56. Kijima, H., Tsuchida, 8T., Kondo, H., Iida, T., Oshika, Y., Nakamura, M., Scanlon, K. J., Kondo, T., and Tamaoki, N. (1998) Hammerhead ribozymes against γ-glutamyleysteine synthetase mRNA down-regulate intracellular glutathione concentration of mouse islet cells. Biochem. Biophys. Res. Commun. 247, 697-703.
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 697-703
    • Kijima, H.1    Tsuchida, T.2    Kondo, H.3    Iida, T.4    Oshika, Y.5    Nakamura, M.6    Scanlon, K.J.7    Kondo, T.8    Tamaoki, N.9
  • 57
    • 0028922624 scopus 로고
    • Effects of antisense oligonucleotides targeting K-ras expression in pancreatic cancer cell lines. Int
    • 57. Carter, G., Gilbert, C., and Lemoine, N. R. (1995) Effects of antisense oligonucleotides targeting K-ras expression in pancreatic cancer cell lines. Int. J. Oncol. 6, 1105-1112.
    • (1995) J. Oncol. , vol.6 , pp. 1105-1112
    • Carter, G.1    Gilbert, C.2    Lemoine, N.R.3
  • 58
    • 0029124127 scopus 로고
    • Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity
    • 58. Aoki, K., Yoshida, T., Sugimura, T., and Terada, M. (1995) Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res. 55, 3810-3816.
    • (1995) Cancer Res. , vol.55 , pp. 3810-3816
    • Aoki, K.1    Yoshida, T.2    Sugimura, T.3    Terada, M.4
  • 60
    • 0028143695 scopus 로고
    • Hammerhead nailed down
    • 60. Cech, T. R., and Uhlenbeck, O.C. (1994) Hammerhead nailed down. Nature 372, 39-40.
    • (1994) Nature , vol.372 , pp. 39-40
    • Cech, T.R.1    Uhlenbeck, O.C.2
  • 61
    • 0029918906 scopus 로고    scopus 로고
    • Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells
    • 61. Ohta, Y., Kijima, H., Kashani-Sabet, M., Scanlon, K. J. (1996) Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells. Nucleic Acids Res. 24, 938-942.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 938-942
    • Ohta, Y.1    Kijima, H.2    Kashani-Sabet, M.3    Scanlon, K.J.4
  • 62
    • 0025353707 scopus 로고
    • Cloning of the complete gene for carcinoembryonic antigen: Analysis of its promoter indicates a region conveying cell type-specific expression
    • 62. Schrewe, H., Thompson, J., Bona, M., Hefta, L. A., Maruya, A., Hassauer, M, Shively, J. H., von Kleist, S., and Zimmermann, W. (1990) Cloning of the complete gene for carcinoembryonic antigen: Analysis of its promoter indicates a region conveying cell type-specific expression. Mol. Cell. Biol., 10, 2738-2748.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2738-2748
    • Schrewe, H.1    Thompson, J.2    Bona, M.3    Hefta, L.A.4    Maruya, A.5    Hassauer, M.6    Shively, J.H.7    Von Kleist, S.A.8    Zimmermann, W.9
  • 63
    • 0028961480 scopus 로고
    • Transcriptional regulation of the carcinoembryonic antigen gene
    • 63. Hauck, W. and Stanners, C. P. (1995) Transcriptional regulation of the carcinoembryonic antigen gene. J. Biol. Chem. 270, 3602-3610.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3602-3610
    • Hauck, W.1    Stanners, C.P.2
  • 64
    • 0028403237 scopus 로고
    • Viral vector systems for gene therapy
    • 64. Jolly, D. (1994) Viral vector systems for gene therapy. Cancer Gene Ther. 1, 51-64.
    • (1994) Cancer Gene Ther. , vol.1 , pp. 51-64
    • Jolly, D.1
  • 65
    • 15444367562 scopus 로고
    • The vector void in gene therapy
    • 65. Hodgson, C.P. (1995) The vector void in gene therapy. Biotechnology 13, 222-225.
    • (1995) Biotechnology , vol.13 , pp. 222-225
    • Hodgson, C.P.1
  • 66
    • 0025850802 scopus 로고
    • Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: More isn't always better
    • 66. Hershlag, D. (1990) Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better. Proc. Natl. Acad. Sci. USA 88, 6921-6925,
    • (1990) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6921-6925
    • Hershlag, D.1
  • 67
    • 0026530097 scopus 로고
    • Hum. gene therapy
    • 67. Anderson, W. F. (1992) Hum. gene therapy. Science 256, 808-813.
    • (1992) Science , vol.256 , pp. 808-813
    • Anderson, W.F.1
  • 69
    • 0024460181 scopus 로고
    • Improved retroviral vectors for gene transfore and expression
    • 69. Miller, A. D. and Rosman, G. J. (1989) Improved retroviral vectors for gene transfore and expression. Biotechniques 7, 980-990.
    • (1989) Biotechniques , vol.7 , pp. 980-990
    • Miller, A.D.1    Rosman, G.J.2
  • 70
    • 0025279872 scopus 로고
    • Gene transfer by retrovirus occures in cell that are actively replicating at the time of infection
    • 70. Miller, D. G., Adam, M. A., and Miller, A. D. (1990) Gene transfer by retrovirus occures in cell that are actively replicating at the time of infection. Mol. Cell Biol. 10, 4239-1242.
    • (1990) Mol. Cell Biol. , vol.10 , pp. 4239-11242
    • Miller, D.G.1    Adam, M.A.2    Miller, A.D.3
  • 72
    • 0002025785 scopus 로고
    • Manipulation of adenovirus vectors
    • 72. Graham, F. L. and Prevec, L. (1991) Manipulation of adenovirus vectors. Methods Mol. Biol. 7, 109-128.
    • (1991) Methods Mol. Biol. , vol.7 , pp. 109-128
    • Graham, F.L.1    Prevec, L.2
  • 73
    • 0001984357 scopus 로고    scopus 로고
    • Ribozyme-mediated reversal of human pancreatic carcinoma phenotype
    • Eds. S. Ikehara, F. Takaku, and R. A. Good. Springer
    • 73. Kijima, H., Bouffard, D. Y., and Scanlon, K. J. (1996) Ribozyme-mediated reversal of human pancreatic carcinoma phenotype. in "Bone Marrow Transplantation - Basic and Clinical studies" (Eds. S. Ikehara, F. Takaku, and R. A. Good) pp. 153-163. Springer.
    • (1996) Bone Marrow Transplantation - Basic and Clinical Studies , pp. 153-163
    • Kijima, H.1    Bouffard, D.Y.2    Scanlon, K.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.