Warfarin exposure and calcification of the arterial system in the rat

International Journal of Experimental Pathology

Volumn 81, Issue 1, 2000, Pages 51-56

  Howe, A M ^a   Webster, W S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Calcification; Matrix gla protein; Vitamin K dependent; Warfarin

Indexed keywords

KONAKIONE; UNCLASSIFIED DRUG; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CALCIFICATION; ARTICLE; CONTROLLED STUDY; KIDNEY CALCIFICATION; NONHUMAN; PRIORITY JOURNAL; RAT; VITAMIN K DEFICIENCY;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; CALCINOSIS; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN K DEFICIENCY; WARFARIN;

EID: 0034021988     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2000.00140.x     Document Type: Article

References (30)

1. BOSTRUM K., WATSON K.E., HORN S., WORTHAM C., HERMAN I.M. & DEMER L.L. (1995) Bone morphogenetic protein expressed in human atherosclerotic lesions. J. Clin. Invest. 91, 1800-1809.
2. BUCAY N., SAROSI I., DUNSTAN C.R. ET AL. (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Devel. 12, 1260-1268.
3. DRURY R.A.B. & WALLINGTON E.A. (1976) Carleton's Histological Technique. London: Oxford University Press, pp. 150-151.
4. DUCY P., DESBOIS C., BOYCE B. ET AL. (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382, 448-452.
5. ESNOUF M.P. & PROWSE C.V. (1977) The gamma-carboxy glutamic acid content of human and bovine prothrombin following warfarin treatment. Biochim. Biophys. Acta 490, 471-476.
6. FERLAND G. (1998) The vitamin K-dependent proteins: an update. Nutr. Rev. 56, 223-230.
7. FOWLER W.E. (1986) A possible cause of hematuria in patients taking warfarin. N. Engl. J. Med. 315, 65.
8. FRASER J.D. & PRICE P.A. (1988) Lung, heart and kidney express high levels of mRNA for the vitamin K-dependent matrix gla protein: implications for the possible functions of matrix Gla protein and the tissue distribution of gamma-carboxylase. J. Biol. Chem. 263, 11033-11036.
9. FRIEDMAN P.A., ROSENBERG R.D., HAUSCHKA P.V. & FITZ-JAMES A. (1977) A spectrum of partially carboxylated prothrombin in the plasma of coumarin-treated patients. Biochim. Biophys. Acta 494, 271-276.
10. FRIEDMAN P.A., MITCH W.E. & SILVA P. (1982) Localization of renal vitamin K-dependent gamma glutamyl carboxylase to tubule cells. J. Biol. Chem. 257, 11037-11040.
11. JIE K.-S.G., GIJSBERS B.L.M.G., KNAPEN M.H.J., HAMULYAK K., FRANK H.L. & VERMEER C. (1993) Effects of vitamin K and oral anticoagulants on urinary calcium excretion. Br. J. Haematol. 83, 100-104.
12. KIMMEL C.A. & TRAMMEL C. (1981) A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. Stain Technol. 56, 271-273.
13. LUO G., DUCY P., MCKEE M.D. ET AL. (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386, 78-81.
14. MCLAIN D.A., GARRIGA F.J. & KANTOR O.S. (1980) Adverse reactions associated with ticrynafen use. J. A. M. A. 243, 763-764.
15. MERLE B. & DELMAS P.D. (1990) Normal carboxylation of circulating osteocalcin (bone Gla-protein) in Paget's disease of bone. Bone Miner. 11, 237-245.
16. MENON R.K., GILL D.S., THOMAS M., KERNOFF P.B.A. & DANDONA P. (1987) Impaired carboxylation of osteocalcin in warfarin treated patients. J. Clin. Endocrinol. Metabol. 64, 59-61.
17. MIKAMI O., YOSHIDA R., MATSUDA T., KOMATZ Y., MATSUSHITA Y. & NAKATANI H. (1992) A case of renal vein thrombosis. Acta Urologica Japonica 38, 817-820.
18. MILLER J.I., MCBEATH R.B. & DRACH G.W. (1991) Urinary hematin calculi. J. Urol. 145, 1043-1044.
19. MONCADA R.M., VENTA L.A., VENTA E.R., FAREED J., WALENGA J.M. & MESSMORE H.L. (1992) Tracheal and bronchial cartilaginous rings: warfarin sodium - induced calcification. Radiology 184, 437-439.
20. NAKAGAWA Y., ABRAM V., KEZDY F.J., KAISER E.T. &COE F. L. (1983) Purification and characterisation of the principal inhibitor of calcium monohydrate crystal growth in human urine. J. Biol. Chem. 257, 11037-11040.
21. PIETSCHMANN P., WOLOSZCZUK W., PANZER S., KYRLE P. & SMOLEN J. (1988) Decreased serum osteocalcin levels in phenprocoumon treated patients. J. Clin. Endocrinol. Metab. 66, 1071-1074.
22. PLANTALECH L., GUILLAUMONT M., VERGNAUD P. & LECLERCQ & DELMAS P.D. (1991) Impairment of gamma carboxylation of circulating osteocalcin (Bone Gla protein) in elderly women. J. Bone Miner. Res. 6, 1211-1216.
23. PRICE P.A., FAUS S.A. & WILLIAMSON M.K. (1998) Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterios. Thromb. Vasc. Biol. 18, 1400-1407.
24. PRICE P. A. & KANEDA Y. (1987) Vitamin K counteracts the effect of warfarin in liver but not in bone. Thrombosis Res. 46, 121-131.
25. PRICE P.A. & WILLIAMSON M.K. (1981) Effects of warfarin on bone: studies on the vitamin K-dependent bone protein of rat bone. J. Biol. Chem. 25, 12754-12759.
26. PROUDFOOT D., SKEPPER J.N., SHANAHAN C.M. & WEISSBERG P.L. (1998) Calcification of human vascular cells in vitro is correlated with high levels of matrix gla protein and low levels of osteopontin expression. Arterioscler. Thromb. Biol. 18, 379-388.
27. RIFKIN M.D. & PRITZKER H.A. (1984) Tracheobronchial cartilage calcification in children. Case reports and review of the literature. Br. J. Radiol. 57, 293-296.
28. SOKOLL L.J., O'BRIEN M.E., CAMILO M.E. & SADOWSKI J.A. (1995) Undercarboxylated osteocalcin and development of a method to determine vitamin K status. Clin. Chem. 41, 1121-1128.
29. TAYBI H. & CAPITANIO M.A. (1990) Tracheobronchial calcification: an observation in three children after mitral valve replacement and warfarin sodium therapy. Radiology 176, 728-730.
30. VAN HAARLEM L.J.M., KNAPEN M.J.H., HAMULYAK K. & VERMEER C. (1988) Circulating osteocalcin during anticoagulant therapy. Thrombos. Haemost. 60, 79-82.