Disparate effects of carvedilol versus metoprolol treatment of stroke- prone spontaneously hypertensive rats on endothelial function of resistance arteries

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 5, 2000, Pages 763-768

  Intengan, Hope D ^a   Schiffrin, Ernesto L ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Adrenoceptors; Acetylcholine; Hydralazine; Relaxation; SHRSP; Vascular remodeling

Indexed keywords

ACETYLCHOLINE; BETA ADRENERGIC RECEPTOR; CARVEDILOL; METOPROLOL; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; ENDOTHELIUM CELL; ESSENTIAL HYPERTENSION; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BODY WEIGHT; CARBAZOLES; CEREBROVASCULAR ACCIDENT; ENDOTHELIUM, VASCULAR; HUMANS; HYPERTENSION; MALE; MESENTERIC ARTERIES; METOPROLOL; PROPANOLAMINES; RATS; RATS, INBRED SHR; VASCULAR RESISTANCE; VASODILATION;

EID: 0034021683     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200005000-00013     Document Type: Article

References (4)

1. Hayakawa H, Raij L. The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension. Hypertension 1997;29:235-41.
2. Hasdia D, Gibbons RJ, Holmes DR Jr, Higano ST, Lerman A. Coronary endothelial dysfunction is associated with myocardial perfusion defects. Circulation 1997;96:3390-5.
3. MacMahon SW, Cutler JA, Stamler J. Antihypertensive drug treatment: potential, expected, and observed effects on stroke and on coronary heart disease. Hypertension 1989;13(suppl I):I-45-50.
4. Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke, and coronary heart disease. Part 2, Short term reductions in blood pressure: overview of randomized drug trials in their epidemiolopical context. Lancet 1990;335:827-38.