Phosphodiesterase inhibitors in the treatment of erectile dysfunction

Drugs of Today

Volumn 36, Issue 2-3, 2000, Pages 93-99

  Stief, Christian G ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL;

CONFERENCE PAPER; CORPUS CAVERNOSUM; DRUG EFFICACY; DRUG MECHANISM; ERECTILE DYSFUNCTION; HUMAN; PATHOGENESIS; SIGNAL TRANSDUCTION;

EID: 0034020733     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2000.36.2-3.568782     Document Type: Conference Paper

References (22)

1. Lue, T.F., Takarnura, T., Schmidt, R.A., Palubinskas, A.J., Tanagho, E.A. Hemodynamics of erection in the monkey. J Urol 1983, 130: 1237-41.
2. Lue, T.F., Tanagho, E.A. Physiology of erection and pharmacological management of impotence. J Urol 1987, 137: 829-36.
3. Andersson, K.E., Wagner, G. Physiology of penile erection. Phamacol Rev 1995, 75: 191-236.
4. Mandrek, K. Electrophysiological methods in smooth muscle physiology. Corpus cavernosum in vitro. World J Urol 1994, 12: 262-5.
5. Mersdorf, A., Goldsmith, P.C., Diederichs, W. et al. Ultrastructural changes in impotent penile tissue: A comparison of 65 patients. J Urol 1991, 145: 749-58.
6. Andersson, K.E., Holmquist, F. Regulation of tone in penile cavernous smooth muscle. Established concepts and new findings. World J Urol 1994, 12: 249-61.
7. G-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiol Scand 1991, 143: 299-304.
8. G-nitro arginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated cor-pus cavernosum. Acta Physiol Scand 1991, 141: 441-2.
9. Ignarro, L.J., Bush, P.A., Buga, G.M., Woods, K.S., Fukuto, J.M., Rajfer, J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990, 170: 843-50.
10. Stief, C.G., Holmquist, F., Allhoff, E.P., Andersson, K.E., Jonas, U. Preliminary report on the effect of the nitric oxide donor SIN-1 on human cavernous tissue in vivo. World J Urol 1991, 9: 237-41.
11. Truss, M.C., Becker, A.J., Schultheiss, D., Jonas, U. Intracavemous pharmacotherapy. World J Urol 1997, 15: 71-7.
12. Gingell, C.J.C., Jardin, A., Olsson, A.M. et al. UK-92480, a new oral treatment for erectile dysfunction: A double-blind, placebo-controlled, once daily dose response study. J Urol 1996, 155: 495A.
13. Chacko, S., Longhurst, P.A. Regulation of actomyosin and contraction in smooth muscle. World J Urol 1994, 12: 292-7.
14. Ruegg, J.C. Muskel. In: Physiologie des Menschen. Springer: Heidelberg 1995, 67-87.
15. Somlyo, A.P., Somlyo, A.V. Signal transduction and regulation in smooth muscle. Nature 1994, 372: 231-6.
16. Walsh, M.P. Regulation of vascular smooth muscle. Can J Physiol Pharmacol 1993, 72: 919-36.
17. Beavo, J.A., Reifsnyder, D.H. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci 1990, 11: 150-5.
18. Thompson, W.J. Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function. Pharmacol Ther 1991, 51: 13-33.
19. Nicholson, C.D., Challiss, R.A., Shahid, M. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol Sci 1991, 12: 19-27.
20. Hall, I.P. Isoenzyme selective phosphodiesterase inhibitors: Potential clinical uses. Br J Clin Pharmacol 1993, 35: 1-7.
21. Beavo, J.A., Conti, M., Heaslip, R.J. Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol 1994, 46: 399-405.
22. Schudt, C., Dent, G., Rabe, K.F. Phosphodiesterase inhibitors. In: The Handbook of Immunopharmacology. Page, C. (Ed.). Academic Press: London 1996.