Basis for nebulized antibiotics: Droplet characterization and in vitro antimicrobial activity versus Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 13, Issue 1, 2000, Pages 11-16

  Todisco, T ^a   Eslami, A ^a   Baglioni, S ^a   Sposini, T ^b   Tascini, C ^b   Sommer, E ^c   Knoch, M ^c  

^a Ospedale Silvestrini   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c PARI GmbH   (Germany)

Author keywords

Aerosolized antibiotics in pneumology; MIC values against Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853) after nebulization; Particle characteristics

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; IMIPENEM; SODIUM CHLORIDE; STREPTOMYCIN; TOBRAMYCIN;

AEROSOL; ANTIMICROBIAL ACTIVITY; BACTERIAL INFECTION; BACTERIUM CULTURE; CONFERENCE PAPER; ESCHERICHIA COLI; INFECTION RISK; NEBULIZATION; PARTICLE SIZE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 0034020505     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2000.13.11     Document Type: Conference Paper

References (43)

1. Hodson, M.E., A.R.L. Penketh, and J.C. Batten. 1981. Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis. Lancet. II(8256):1137-1139.
2. Levy, J., A.L. Smith, M.A. Kenny, Ramsey, B., and Schoenknecht, F.D. 1983. Bioactivity of gentamicin in purulent sputum from patients with CF or bronchiectasis comparison with activity in serum. J. Infect. Dis. 148:1069-1076.
3. MacIntyre, N., R. Silver, C. Miller, F. Schuler, and E. Coleman. 1985. Aerosol delivery in intubated, mechanically ventilated patients. Crit. Care Med. 13:81-84.
4. Littlewood, J.M., M.G. Miller, A.T. Ghoneim, and C.H. Ramsden. 1985. Nebulised colomycin for early pseudomonas colonisation in cystic fibrosis. Lancet. 1:865.
5. Gough, P., and N. Jordan. 1982. A review of the therapeutic efficacy of aerosolized and endotracheally instilled antibiotics. Pharmacotherapy. 2:367-377.
6. Fuller, H.D. 1995. Aerosol deposition in mechanically ventilated patients. Respir. Therapy International. Fall:21-24.
7. Stead, R.J., M.E. Hodson, and J.C. Batten. 1987. Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. Br. J. Dis, Chest. 81:272-278.
8. Palmer, L.B., and G.C. Smaldone. 1994. Aerosolized antibiotics in mechanically ventilated patients: Effects on respiratory secretions [abstract]. Am. J. Respir. Crit. Care Med. 149:A970.
9. Ramsey, B.W., H.L. Dorkin, J.D. Eisenberg, R.L. Gibson, I.R. Harwood, R.M. Kravitz, D.V. Schidlow, R.W. Wilmott, S.J. Astley, M.A. McBurnie, K. Wentz, and A.L. Smith. 1993. Efficacy of aerosolized tobramycin in patients with cystic fibrosis. N. Engl. J. Med. 328: 1740-1746.
10. Knoch, M., E. Wunderlich, and S. Geldner. 1994. A nebulizer system for highly reproducible aerosol delivery. J. Aerosol Med. 7:229-237.
11. Steinkamp, G., B. Tummler, M. Gappa. 1989. Long-term tobramycin aerosol therapy in cystic fibrosis. Pediatr. Pulmonol. 6:91-98.
12. Touw, D.J., R.W. Brimicombe, M.E. Hodson, H.G.M. Heijerman, and W. Bakker. 1995. Inhalation of antibiotics in cystic fibrosis. Eur. Respir. J. 8:1594-1604.
13. Franz, M.N., W.A. Spohn, and P.M. Ronald. 1985. Evaluation of aerosol tobramycin therapy in CF [abstract]. Presented at the 26th Annual Meeting of the Cystic Fibrosis Foundation, Anaheim, May 16-19.
14. Smith, A.L., B.W. Ramsey, D.L. Hedges, Weber, A. 1989. Safety of aerosol tobramycin administration for 3 months to patients with cystic fibrosis. Pediatr. Pulmonol. 7:265-271.
15. Weber, A., A. Smith, J. Williams-Warren, B. Ramsey, and D.S. Covert. 1994. Nebulizer delivery of tobramycin to the lower respiratory tract. Pediatr. Pulmonol. 17:331-339.
16. Hodson, M.E. 1988. Antibiotic treatment: Aerosol therapy. Chest. 94(suppl):156S-162S.
17. MacLusky, I., H. Levison, R. Gold, and P.J. McLaughlin. 1986. Inhaled antibiotics in cystic fibrosis: Is there a therapeutic effect? J. Pediatr. 108:861-865.
18. O'Riordan, T.G., M.J. Greco, R.J. Perry, and G.C. Smaldone. 1992. Nebulizer function during mechanical ventilation. Am. Rev. Respir. Dis. 145:1117-1122.
19. O'Riordan, T.G., and G.C. Smaldone. 1994. Regional deposition and regional ventilation during inhalation of pentamidine. Chest. 105:395-401.
20. Smaldone, G.C., L.B. Palmer, and T.G. O'Riordan. 1994. Delivery of aerosolized antibiotics to mechanically ventilated patients [abstract]. Am. J. Respir. Crit. Care Med. 149:A970.
21. Rogers, D.F., and D. Ganderton. 1995. Determining equivalence of inhaled medications. Workshop report. Respir. Med. 89:253-261.
22. Derom, E., and R. Pauwels. 1995. Bioequivalence of inhaled drugs. Eur. Respir. J. 8:1634-1636.
23. O'Riordan, T.G., and J.C. Amram. 1997. Effect of nebulizer configuration on delivery of aerosolized tobramycin. J. Aerosol Med. 10:13-23.
24. Fiel, S.B. 1995. Aerosol delivery of antibiotics to the lower airways of patients with cystic fibrosis. Chest. 107(suppl 2):61S-64S.
25. Huet, F., and J.L. Nivelon. 1997. Aerosol therapy and cystic fibrosis: A national survey. Rev. Pneumol. Clin. 53:91-97.
26. Harris, C.E., and R.W. Wilmott. 1994. Inhalation-based therapies in the treatment of cystic fibrosis. Curr. Opin. Pediatr. 6:234-238.
27. Eisenberg, J., M. Pepe, J. Williams-Warren, M. Vasiliev, A.B. Montgomery, A.L. Smith, and B.W. Ramsey. 1997. A comparison of peak sputum tobramycin concentration in patients with cystic fibrosis using jet and ultrasonic nebulizer systems. Chest. 111:955-962.
28. Le Conte, P., G. Potel, P. Peltier, D. Horeau, J. Caillon, M.E. Juvin, M.-F. Kerguéris, D. Bugnon, and D. Baron. 1993. Lung distribution and pharmacokinetics of aerosolized tobramycin. Am. Rev. Respir. Dis. 147: 1279-1282.
29. Smith, A.L., and B. Ramsey. 1995. Aerosol administration of antibiotics. Pediatr. Pulmonol. 11P(suppl):68-69.
30. Cohn, R.C., and L. Rudzienski. 1994. In vitro suppression of Pseudomonas cepacia after limited exposure to subinhibitory concentrations of amiloride and 5-(N,N-hexamethylene) amiloride. Pediatr. Pulmonol. 16: 366-369.
31. Tag El-Din, M.A., L.B. Palmer, M.N. El-Tayeb, I. Khalil, and M.S. Gabr. 1994. Nebulizer therapy with antibiotics in chronic suppurative lung disease. J. Aerosol Med. 7:345-350.
32. Ramsey, B.W., M.S. Pepe, J.M. Quan, K.L. Otto, A.B. Montgomery, J. Williams-Warren, M. Vasiljev, D. Borowitz, C.M. Bowman, B.C. Marshall, S. Marshall, and A.L. Smith for the Cystic Fibrosis Inhaled Tobramycin Study Group. 1999. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. N. Engl. J. Med. 340:23-30.
33. National Committee for Clinical Laboratory Standards. 1993. Performance Standards for Antimicrobial Susceptibility Testing-Fifth International Supplement, Document M100-S5. NCCLS, Villanova, PA.
34. Wilson, R. 1998. The role of infection in COPD. Chest. 113(suppl):242S-248S.
35. Soler, N., A. Torres, S. Ewig, J. Gonzalez, R. Celis, M. El-Ebiary, C. Hernandez, and R. Rodriguez-Roisin. 1998. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am. J. Respir. Crit. Care Med. 157:1498-1505.
36. Martinez, J.A., E. Rodriguez, T. Bastida, J. Buges, and M. Torres. 1994. Quantitative study of the bronchial bacterial flora in acute exacerbations of chronic bronchitis. Chest. 105:976.
37. Newman, S.P., and S.W. Clarke. 1983. Therapeutic aerosols 1: Physical and practical considerations. Thorax. 38:881-886.
38. Nikander, K. 1997. Some technical, physicochemical and physiological aspects of nebulization of drugs. Eur. Respir. Rev. 7:168-172.
39. Diot, P., F. Gagnadoux, C. Martin, H. Ellataoui, Y. Furet, M. Breteau, E. Boissinot, and E. Lemarié. 1997. Nebulization and anti-Pseudomonas aeruginosa activity of colistin. Eur. Respir. J. 10:1995-1998.
40. Lietman, P.S. Aminoglycosides and streptomycin. In G.L. Mandell, R.G. Douglas, and J.E. Bennett, eds. Principles and Practice of Infectious Diseases, 3rd ed. Churchill Livingstone, New York, 1990, pp. 257-279.
41. Rikimaru, T. 1994. Evaluation of aerosol therapy of streptomycin for tracheobronchial tuberculosis. Kekkaku. 69:733-738.
42. Semenova, E.V. 1977. Basis for the administration of streptomycin and isoniazid in ultrasonic aerosols in the treatment of intrathoracic tuberculosis. Antibiot. Khimioter. 22:469-471.
43. 1990. Basic principles in the diagnosis and management of infectious diseases. In G.L. Mandell, R.G. Douglas, and J.E. Bennett, eds. Principles and Practice of Infectious Diseases, 3rd ed. Churchill Livingstone, New York, 1990, pp. 257-279.