The pathology of liver-localized post-transplant lymphoproliferative disease: A report of three cases and a review of the literature

American Journal of Surgical Pathology

Volumn 24, Issue 5, 2000, Pages 733-741

  Nuckols, J Dean ^a   Baron, Pedro W ^b   Stenzel, Timothy T ^b   Olatidoye, Babatunde A ^b   Tuttle Newhall, Janet E ^b   Clavien, Pierre Alain ^b   Howell, David N ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b NONE

Author keywords

Epstein Barr virus; Liver transplantation; Polymerase chain reaction; Post transplantation lymphoproliferative disease

Indexed keywords

CYCLOSPORIN A; DNA; IMMUNOSUPPRESSIVE AGENT;

ADULT; ARTICLE; CASE REPORT; EPSTEIN BARR VIRUS; FEMALE; GRAFT REJECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MALE; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATION;

ADULT; DNA, NEOPLASM; FEMALE; GENOTYPE; HUMANS; LIVER DISEASES; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS;

EID: 0034020266     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200005000-00013     Document Type: Article

References (64)

1. Alfrey EJ, Friedman AH, Grossman RA, et al. Two distinct patterns of post-transplantation lymphoproliferative disorder (PTLD): early and late onset. Clin Transplant 1992;6:246-8.
2. Ambinder RF, Mann RB. Detection and characterization of Epstein-Barr virus in clinical specimens. Am J Pathol 1994;145:239-52.
3. Armes JE, Angus P, Southey MC, et al. Lymphoproliferative disease of donor origin arising in patients after orthotopic liver transplantation. Cancer 1994;74:2436-41.
4. Atencio IA, Shadan FF, Zhou XJ, Vaziri ND, Villarreal LP. Adult mouse kidneys become permissive to acute polyomavirus infection and reactivate persistent infection in response to cellular damage and regeneration. J Virol 1993;67:1424-32.
5. Barkholt L, Billing H, Juliusson G, Porwit A, Ericzon B, Groth C. B-cell lymphoma in transplanted liver: clinical, histological and radiological manifestation. Transpl Int 1991;4:8-11.
6. Chadburn A, Cesarman E, Knowles DM. Molecular pathology of posttransplantation lymphoproliferative disorders. Semin Diagn Pathol 1997;14:15-26.
7. Chadburn A, Suciu-Foca N, Cesarman E, Reed E, Michler RE, Knowles DM. Post-transplantation lymphoproliferative disorders arising in solid organ transplant recipients are usually of recipient origin. Am J Pathol 1995;147:1862-70.
8. Cherqui D, Duvoux C, Plassa F, et al. Lymphoproliferative disorder of donor origin in a liver transplant recipient: complete remission after drastic reduction of immunosuppression without graft loss. Transplantation 1993;56:1023-6.
9. Cohen JI. Epstein-Barr virus lymphoproliferative disease associated with acquired immunodeficiency. Medicine (Balt) 1991;70: 137-60.
10. Craig FE, Gulley ML. Banks PM. Posttransplantation lymphoproliferative disorders. Am J Clin Pathol 1993;99:265-76.
11. Egawa H, Inomata Y, Uemoto S, et al. Lymphoproliferative disorders in patients undergoing living-related liver transplantation. Transplant Proc 1998;30:136-7.
12. Hanto DW, Frizzera G, Gajl-Peczalska KJ, et al. Epstein-Barr virus-induced B-cell lymphoma after renal transplantation. N Engl J Med 1982;306:913-8.
13. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Simmons RL. Epstein-Barr virus, immunodeficiency, and B-cell lymphoproliferation. Transplantation 1985;39:461-72.
14. Harris KM, Schwanz ML, Slasky BS, Nalesnik M, Makowka L. Posttransplantation cyclosporine-induced lymphoproliferative disorders: clinical and radiologic manifestations. Radiology 1987; 162:697-700.
15. Hegele RG, Bicknell SG, Bailey DJ, Cameron RG. In situ hybridization for the Y chromosome reveals a donor origin for a posttransplant lymphoproliferative disorder in a sex-mismatched hepatic allograft. Arch Pathol Lab Med 1994;118:795-6.
16. Hjelle B, Evans-Holm M, Yen TSB, Garovay M, Guis M, Edman JC. A poorly differentiated lymphoma of donor origin in a renal allograft recipient. Transplantation 1989;47:945-8.
17. Ho M, Jaffe R, Miller G, et al. The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation 1988;45:719-27.
18. Howell DN, Smith SR, Butterly DW, et al. Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients. Transplantation 1999;68:1279-87.
19. Kingma DW, Weiss WB, Jaffe ES, Kumar S, Frekko K, Raffeld M. Epstein-Barr virus latent membrane protein-1 oncogene deletions: correlations with malignancy in Epstein-Barr virus-associated lymphoproliferative disorders and malignant lymphomas. Blood 1996; 88:242-51.
20. Klintmalm GB. De novo lymphoma after liver transplantation. Clin Transplant 1992;6:272-4.
21. Kok T, Van der Sluis A, Klein JP, et al. Ultrasound and cholangiography for the diagnosis of biliary complications after orthotopic liver transplantation: a comparative study. J Clin Ultrasound 1996;24:13-5.
22. Kroes AC, van der Pijl JW, van TM, et al. Rapid occurrence of lymphoproliferative disease after pancreas-kidney transplantation performed during acute primary Epstein-Barr virus infection. Clin Infect Dis 1997;24:339-43.
23. Larson RS, Scott MA, McCurley TL, Vnencak-Jones CL. Microsatellite analysis of posttransplant lymphoproliferative disorders: determination of donor/recipient origin and identification of putative lymphomagenic mechanism. Cancer Res 1996;56:4378-81.
24. Le Frere-Belda MA, Martin N, Gaulard P, Zafrani ES. Donor or recipient origin of post-transplantation lymphoproliferative disorders: evaluation by in situ hybridization. Mod Pathol 1997;10: 701-7.
25. Legendre C, Kreis H. Effect of immunosuppression on the incidence of lymphoma formation. Clin Transpl 1992;56:220-1.
26. Levy M, Backman L, Husberg B, et al. De novo malignancy following liver transplantation: a single center study. Transplant Proc 1993;25:1397-9.
27. Lones MA, Lopez-Terrada D, Weiss LM, Shintaku IP, Said JW. Donor origin of posttransplant lymphoproliferative disorder localized to a liver allograft: demonstration by fluorescence in situ hybridization. Arch Pathol Lab Med 1997;121:701-6.
28. Malatack JF, Gartner JCJ, Urbach AH, Zitelli BJ. Orthotopic liver transplantation. Epstein-Barr virus, cyclosporine, and lymphoproliferative disease: a growing concern. J Pediatr 1991;118:667-75.
29. McAlister V, Grant D, Roy A, Yilmaz Z, Ghent C, Wall W. Posttransplant lymphoproliferative disorders in liver recipients treated with OKT3 or ALG induction immunosuppression. Transplant Proc 1993;25:1400-1.
30. Meduri G, Fromentin L, Viellefond A, Fries D. Donor-related non-Hodgkin's lymphoma in a renal allograft recipient. Transplant Proc 1991;23:2649-9.
31. Mentzer SJ, Longtine J, Fingeroth J, et al. Immunoblastic lymphoma of donor origin in the allograft after lung transplantation. Transplantation 1996;61:1720-5.
32. Miller WJ, Campbell WL, Zajko AB, et al. Obstructive dilatation of extrahepatic recipient and donor bile ducts complicating orthotopic liver transplantation: imaging and laboratory findings. Am J Roentgenol 1991;157:29-32.
33. Minello-Franza A, Berjamy F, Bresson-Hadni S, et al. Lymphoproliferative disorders in four orthotopic liver transplant patients. Transplant Proc 1995;27:1770-3.
34. Moody AR, Wilson SR, Greig PD. Non-Hodgkin lymphoma in the porta hepatitis after orthotopic liver transplantation: sonographic findings. Radiology 1992;182:867-70.
35. Nalesnik MS, Jaffe R, Starzl TE, et al. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 1988; 133:173-91.
36. Nalesnik MS, Locker J, Jaffe R, et al. Experience with posttransplant lymphoproliferative disorders in solid organ transplant recipients. Clin Transpl 1992;6:248-52.
37. Navarro F, Pyda P, Pageaux GP, et al. Lymphoproliferative disease after liver transplantation: primary biliary localization. Transplant Proc 1998;30:1486-8.
38. Nuckols JD, Rasheed BKA, McGlennen RC, Bigner SH, Stenzel TT. Evaluation of an automated technique for assessment of marrow engraftment following allogeneic bone marrow transplantation using a commercially available kit. Am J Clin Pathol 2000;113: 135-40.
39. Nuckols JD, Thomas CY. The mouse H-2A region influences the envelope gene structure of tumor-associated murine leukemia viruses. J Virol 1998;72:3973-9.
40. O'Connor TP, Lewis WD, Jenkins RL. Biliary tract complications after liver transplantation. Arch Surg 1995;130:312-7.
41. Palazzo JP, Lundquist K, Mitchell D, et al. Rapid development of lymphoma following liver transplantation in a recipient with hepatitis B and primary hemochromatosis. Am J Gastroenterol 1993; 88:102-4.
42. Penn I. Lymphomas complicating organ transplantation. Transplant Proc 1983;15:2790-7.
43. Penn I. The changing pattern of posttransplant malignancies. Transplant Proc 1991;23:1101-3.
44. Penn I. Immunosuppression - a contributory factor in lymphoma formation. Clin Transpl 1992;6:214-9.
45. Portmann B, Schindler A-M, Murray-Lyon IM, Williams R. Histological sexing of a reticulum cell sarcoma arising after liver transplantation. Gastroenlerology 1976;70:82-4.
46. Preiksaitis JK. Lymphoproliferative disorder in renal transplant recipients: virologic aspects. Clin Transpl 1992;6:235-9.
47. Randhawa P, Demetris J, Nalesnik MA. EBER gene expression in Epstein-Barr virus-associated hematopoietic neoplasms. Leuk Lymphoma 1994;13:387-92.
48. Randhawa PS, Jaffe R, Demetris AJ, et al. Expression of Epstein-Barr virus-encoded small RNA (by the EBER-1 gene) in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease. N Engl J Med 1992;327:1710-4.
49. Randhawa PS. Yousem SA. Epstein-Barr virus-associated lymphoproliferative disease in a heart-lung allograft. Demonstration of host origin by restriction fragment-length polymorphism analysis. Transplantation 1990;49:126-30.
50. Raymond E, Tricottet V, Samuel D, Reynes M, Bismuth H, Misset J. Epstein-Barr virus-related localized hepatic lymphoproliferative disorders after liver transplantation. Cancer 1995;76:1344-51.
51. Renoult E, Aymard B, Gregoire MJ, et al. Epstein-Barr virus lymphoproliferative disease of donor origin after kidney transplantation: a case report. Am J Kidney Dis 1995;26:84-7.
52. Reyes J, Tzakis A, Green M, et al. Posttransplant lymphoproliferative disorders occurring under primary FK 506 immunosuppression. Transplant Proc 1991;23:3044-6.
53. Rizk RS, McVicar JP, Emond MJ, et al. Endoscopic management of biliary strictures in liver transplant recipients: effect on patient and graft survival. Gastrointest Endosc 1998;47:128-35.
54. Sasahara Y, Kawai S, Itano M, et al. Epstein-Barr virus-associated lymphoproliferative disorder after unrelated bone marrow transplantation in a young child with Wiskott-Aldrich syndrome. Pediatr Hematol Oncol 1998;15:347-52.
55. Shapiro RS, McClain K, Frizzera G, et al. Epstein-Barr virus associated B cell lymphoproliferative disorders following bone marrow transplantation. Blood 1988;71:1234-43.
56. Sokal EM, Caragiozoglou T, Lamy M, Reding R, Otte JB. Epstein-Barr virus serology and Epstein-Barr virus-associated lymphoproliferative disorders in pediatric liver transplant recipients. Transplantation 1993;56:1394-8.
57. Spiro I, Yandell DW, Li C, et al. Brief Report: lymphoma of donor origin occurring in the porta hepatis of a transplanted liver. N Engl J Med 1993;329:27-9.
58. Starzl TE, Nalesnik MA, Porter KA, et al. Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1984;1:583-7.
59. Strazzabosco M, Corneo B, Iemmolo RM, et al. Epstein-Barr virus-associated post-transplant lymphoproliferative disease of donor origin in liver transplant recipients. J Hepatol 1997;26:926-34.
60. Strouse PJ, Platt JF, Francis IR, Bree RL. Tumorous intrahepatic lymphoproliferative disorder in transplanted livers. AJR Am J Roentgenol 1996;167:1159-62.
61. Vortmeyer AO, Kingma DW, Fenton RG, Curti BD, Jaffe ES, Duray PH. Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein-Barr virus. Am J Clin Pathol 1998;109:90-5.
62. Weissmann DJ, Ferry JA, Harris NL, Louis DN, Delmonico F, Spiro I. Posttransplantation lymphoproliferative disorders in solid organ recipients are predominantly aggressive tumors of host origin. Am J Clin Pathol 1995;103:748-55.
63. Wood BL, Sabath D, Broudy VC, Raghu G. The recipient origin of posttransplant lymphoproliferative disorders in pulmonary transplant patients. A report of three cases. Cancer 1996;78:2223-8.
64. Wu TT, Swerdlow SH, Locker J, et al. Recurrent Epstein-Barr virus-associated lesions in organ transplant recipients. Hum Pathol 1996;27:157-64.