Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to Diethylstilbestrol (DES)

Toxicologic Pathology

Volumn 28, Issue 2, 2000, Pages 237-245

  Yoshida, Akiyoshi ^a   Newbold, Retha R ^a   Dixon, Darlene ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

c fos; endocrine disrupters; environmental estrogens; estrogen receptor; lactoferrin; Neonatal mouse uterus; p21; p53

Indexed keywords

DIETHYLSTILBESTROL; ESTROGEN RECEPTOR ALPHA; PROTEIN P21;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENDOMETRIUM CANCER; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; DIETHYLSTILBESTROL; ENDOMETRIUM; EPITHELIAL CELLS; ESTROGEN RECEPTOR ALPHA; ESTROGENS, NON-STEROIDAL; FEMALE; IMMUNOHISTOCHEMISTRY; INJECTIONS, SUBCUTANEOUS; LACTOFERRIN; MICE; ONCOGENE PROTEIN P21(RAS); PREGNANCY; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, ESTROGEN;

ANIMALIA; ZEA MAYS;

EID: 0034019785     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800203     Document Type: Article

References (35)

1. Barret JC, Tsutsui T. (1996). Mechanisms of estrogen-associated carcinogenesis. In: Cellular and Molecular Mechanisms of Hormonal Carcinogenesis. Environmental Influences, Huff J, Boyd J, Barrett JC (eds). Wiley-Liss, New York, pp 105-111.
2. Bern HA, Edery M., Mills KT, Kohrman AF, Mori T., Larson L. (1987). Long-term alterations in histology and steroid receptor levels of genital tract and mammary gland following neonatal exposure of female BALB/cCrgl mice to various doses of diethylstilbestrol. Cancer Res 47: 4165-4172.
3. Boettger-Tong HL, Murthy L., Stancel GM (1995). Cellular pattern of c-fos induction by estradiol in the immature rat uterus. Biol Reprod 53: 1398-1406.
4. Brody JR, Cunha GR (1989). Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development. Am J Anat 186: 21-42.
5. Couse JF, Cutis SW, Washburn TF, Lindzey J., Golding TS, Lubahn DB, Smithies O., Korach KS (1995). Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol Endocrinol 9: 1441-1454.
6. El-Deiry WS, Tokino T., Waldman T., Oliner JD, Velculescu VE, Burrell M., Hill DE, Healy E., Rees JL, Hamilton SR, Kinzler KW, Vogelstein B. (1995). Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 55: 2910-2919.
7. Falck L., Forsberg JG (1996). Immunohistochemical studies on the expression and estrogen dependency of EGF and its receptor and c-fos proto-oncogene in the uterus and vagina of normal and neonatally estrogen-treated mice. Anat Rec 245: 459-471.
8. Gibson Dfc, Roberts SA, Evans GS (1991). Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment. Eur J Cancer 27: 1295-1301.
9. Greco TL, Furlow JD, Duello TM, Gorski J. (1991). Immunodetection of estrogen receptors in fetal and neonatal female mouse reproductive tracts. Endocrinology 129: 1326-1332.
10. Halling A., Forsberg JG (1993). Acute and permanent growth effects in the mouse uterus after neonatal treatment with estrogens. Reprod Toxicol 7: 137-153.
11. Howard AB, Talamantes FJ (1981). Neonatal mouse models and their relation to disease in the human female. In: Developmental Effects of Diethylstilbestrol (DES) in Pregnancy, Herbst AL, Bern HA (eds). Thieme-Stratton, New York, pp 129-147.
12. Hyder SM, Stancel GM, Loose-Mitchell DS (1994). Steroid hormone-induced expression of oncogene encoded nuclear proteins. Crit Rev Eukary Gene Express 4: 55-116.
13. Kamiya K., Sato T., Nishimura N., Goto Y., Kano K., Iguchi T. (1996). Expression of estrogen receptor and proto-oncogene messenger ribonucleic acids in reproductive tracts of neonatally diethylstilbestrol-exposed female mice with or without postpuberal estrogen administration. Exp Clin Endocrinol Diabetes 104: 111-122.
14. Kapur S., Tamada H., Dey SK, Andrews GK (1992). Expression of insulin-like growth factor-1 (IGF-1) and its receptor in the peri-implantation mouse uterus, and cell-specific regulation of IGF-1 gene expression by estradiol and progesterone. Biol Reprod 46: 208-219.
15. Korach KS, Hirogome T., Tomooka Y., Yamashita S., Newbold RR, McLachlan JA (1988). Immunodetection of estrogen receptor in epithelial and stromal tissues of neonatal mouse uterus. Proc Natl Acad Sci USA 85: 3334-3337.
16. Manni A., Baker R., Arafah BM, Pearson OH (1981). Uterine oestrogen and progesterone receptors in the ovariectomized rat. J Endocrinol 91: 281-287.
17. McLachlan JA, Newbold RR (1996). Cellular and molecular mechanisms of cancers of the uterus in animals. In: Cellular and Molecular Mechanisms of Hormonal Carcinogenesis. Environmental Influences, Huff J, Boyd J, Barrett JC (eds). Wiley-Liss, New York, pp 175-182.
18. Medlock KL, Sheehan DM, Nelson CJ, Branham WS (1988). Effects of postnatal DES treatment on uterine growth, development, and estrogen receptor levels. J Steroid Biochem 29: 527-532.
19. Nelson KG, Sakai Y., Eitzman B., Steed T., McLachlan J. (1994). Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes. Cell Growth Differ 5: 595-606.
20. Nelson KG, Takahashi T., Bossert NL, Walmer DK, McLachlan JA (1991). Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. Proc Natl Acad Sci USA 88: 21-25.
21. Nelson KG, Takahashi T., Lee DC, Luetteke NC, Bossert NL, Ross K., Eitzman BE, McLachlan JA (1992). Transforming growth factor-α is a potential mediator of estrogen action in the mouse uterus. Endocrinology 131: 1657-1664.
22. Newbold RR, Bullock BC, McLachlan JA (1990). Uterine adenocarcinoma in mice following developmental treatment with estrogens: A model for hormonal carcinogenesis. Cancer Res 50: 7677-7681.
23. Newbold RR, Hanson RB, Jefferson WN (1997). Ontogeny of lactoferrin in the developing mouse uterus: A marker of early hormone response. Biol Reprod 56: 1147-1157.
24. Newbold RR, Hanson RB, Jefferson WN, Bullock B., Haseman J., McLachlan JA (1998). Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 19: 1655-1663.
25. Palazzo JP, WE Mercer, Kovatich AJ, McHugh M. (1997). Immunohistochemical localization of p21WAF1/CIP1 in normal, hyperplastic, and neoplastic uterine tissues. Hum Pathol 27: 60-66.
26. Papa M., Mezzogiorno V., Bresciani F. Weisz A (1991). Estrogen induces c-fos expression specifically in the luminal and glandular epithelia of adult rat uterus. Biochem Biophys Res Commun 175: 480-485.
27. Parker SB, Eichele G., Zhang P Rawls A., Sands AT, Bradley A., Olson EN, Harper JW, Elledge SJ (1995). p53-Independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267: 1024-1027.
28. Pentecost BT, Teng CT (1987). Lactoferrin is the major estrogen inducible protein of mouse uterine secretions. J Biol Chem 25: 10134-10139.
29. Sato T., Ohta Y., Okamura H., Hayashi S., Iguchi T. (1996). Estrogen receptor (ER) and its messenger ribonucleic acid expression in the genital tract of female mice exposed neonatally to tamoxifen and diethylstilbestrol. Anat Rec 244: 374-385.
30. Sato T., Okamura H., Ohta Y., Hayashi S., Takamatsu Y., Takasugi N., Iguchi T. (1992). Estrogen receptor expression in the genital tract of female mice treated neonatally with diethylstilbestrol. In Vivo 6: 151-156.
31. Weisz A., Bresciani F. (1988). Estrogen induces expression of c-fos and c-myc protooncogenes in rat uterus. Mol Endocrinol 2: 816-824.
32. Yamashita S., Newbold RR, McLachlan JA, Korach KS (1989). Developmental pattern of estrogen receptor expression in female mouse genital tracts. Endocrinology 125: 2888-2896.
33. Yamashita S., Newbold RR, McLachlan JA, Korach KS (1990). The role of the estrogen receptor in uterine epithelial proliferation and cytodifferentiation in neonatal mice. Endocrinology 127: 2456-2463.
34. Yoshida A., Newbold RR, Dixon D. (1999). Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice. Toxicol Pathol 27: 325-333.
35. Zheng X., Hendry WJ III (1997). Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus. Cell Growth Differ 8: 425-434.