Hepatic α- and β-adrenergic receptors are not essential for the increase in R(a) during exercise in diabetes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 278, Issue 3 41-3, 2000, Pages

  Coker, Robert H ^a,b   Lacy, D Brooks ^a   Williams, Phillip E ^a   Wasserman, David H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Catecholamines; Glucagon; Glucose production; Insulin; Liver

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; GLUCAGON; GLUCOSE; INSULIN;

ADRENERGIC RECEPTOR BLOCKING; ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOG; EXERCISE; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIVER; LIVER FUNCTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0034018511     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.278.3.e444     Document Type: Article

References (31)

1. Ahlborg, G., and A. Juhlin-Dannfelt. Effect of β-receptor blockade on splanchnic and muscle metabolism during prolonged exercise in men. J. Appl. Physiol. 76: 1037-1042, 1994.
2. Bjorkman, O., P. Miles, D. H. Wasserman, L. Lickley, and M. Vranic. Muscle glucose uptake during exercise in total insulin deficiency: No effect of β-adrenergic blockade. J. Clin. Invest. 81: 1759-1767, 1988.
3. Cherrington, A. D., W. W. Lacy, and J. L. Chiasson. Effect of glucagon on glucose production during insulin deficiency in the dog. J. Clin. Invest. 62: 664-677, 1978.
4. Chiasson, J. L., J. E. Liljenquist, A. S. Jennings, W. W. Lacy, and A. D. Cherrington. Gluconeogenesis: methodological approaches in vivo. Federation Proc. 36: 230-235, 1977.
5. Chu, C. A., D. K. Sindelar, D. W. Neal, and A. D. Cherrington. Portal adrenergic blockade does not inhibit the gluconeogenic effects of circulating catecholamines on the liver. Metabolism 46: 458-465, 1997.
6. Coker, R. H., M. G. Krishna, D. B. Lacy, D. P. Bracy, and D. H. Wasserman. Role of hepatic α-and β-adrenergic receptor stimulation on hepatic glucose production during heavy exercise. Am. J. Physiol. Endocrinol. Metab. 273: E831-E838, 1997.
7. Coker, R. H., M. G. Krishna, D. B. Lacy, B. Zinker, and D. H. Wasserman. Sympathetic drive to liver and nonhepatic splanchnic tissue during prolonged exercise is increased in diabetes. Metabolism 46: 1327-1332, 1997.
8. Coker, R. H., D. B. Lacy, M. G. Krishna, and D. H. Wasserman. Splanchnic glucagon kinetics in exercising alloxan-diabetic dogs. J. Appl. Physiol. 86: 1626-1631, 1999.
9. Connolly, C. C., R. W. Stevenson, D. W. Neal, D. H. Wasserman, and A. D. Cherrington. The effects of lactate loading on alanine and glucose metabolism in the conscious dog. Metabolism 42: 154-161, 1993.
10. C]glucose. Recent Prog. Harm. Res. 19: 445-448, 1963.
11. Galbo, H., N. J. Christensen, and J. J. Hoist. Catecholamines and pancreatic hormones during autonomic blockade in exercising man. Acta Physiol. Scand. 101: 428-437, 1977.
12. Golstein, D. S., G. Feurstein, and J. L. Izzo. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma norepinphrine and epinephrine in man. Life Sci. 28: 467-475, 1981.
13. Hetenyi, G. Calculation of the rate of gluconeogenesis in vivo. In: Carbohydrate Metabolism, edited by C. Cobelli and R. N. Bergman. New York: Wiley, 1981, p. 2091-2109.
14. Kjaer, M., K. Engfred, A. Fernandez, N. Secher, and H. Galbo. Regulation of hepatic glucose production during exercise in humans: role of sympathoadrenergic activity. Am. J. Physiol. Endocrinol. Metab. 265: E275-E283, 1993.
15. Lloyd, B., J. Burrin, P. Smythe, and K. G. M. M. Alberti. Enzymatic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin. Chem. 24: 1724-1729, 1978.
16. Luyckx, A. S., and P. J. Lefebvre. Mechanisms involved in the exercise-induced increase in glucagon secretion in rats. Diabetes 23: 81-93, 1974.
17. Morgan, C. R., and A. L. Lazarow. Immunoassay of insulin: two antibody system. Plasma insulin of normal, subdiabetic, and diabetic rats. Am. J. Med. Sci. 257: 415-419, 1963.
18. Samols, E., and G. C. Weir. Adrenergic modulation of pancreatic A, B, and D cells. J. Clin. Invest. 63: 230-238, 1979.
19. Shamoon, H., R. Hendler, and R. S. Sherwin. Altered responsiveness to cortisol, epinephrine, and glucagon in insulin-infused juvenile-onset diabetics: a mechanism for diabetic instability. Diabetes 29: 284-291, 1980.
20. Shamoon, H., and R. S. Sherwin. β-Adrenergic blockade is more effective in suppressing adrenaline-induced glucose production in Type 1 (insulin-dependent) diabetes. Diabetologia 26: 183-189, 1984.
21. Sherwin, R. S., H. Shamoon, R. Hendler, L. Sacca, N. Eigler, and M. Walesky. Epinephrine and the regulation of glucose metabolism: effect of diabetes and hormonal interactions. Metab. Clin. Exp. 29: 1146-1154, 1980.
22. Simonson, D. C., V. A. Koivisto, R. S. Sherwin, E. Ferrannini, R. Hendler, and R. A. Defronzo. Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics. J. Clin. Invest. 73: 1648-1658, 1984.
23. Vranic, M., R. Kawamori, S. Pek, N. Kovacevic, and G. Wrenshall. The essentiality of insulin and the role of glucagon in regulating glucose utilization and production during strenuous exercise in dogs. J. Clin. Invest. 57: 245-255, 1976.
24. Wahren, J., L. Hagenfeldt, and P. Felig. Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. J. Clin. Invest. 55: 1303-1314, 1975.
25. Wasserman, D. H., J. L. Bupp, J. L. Johnson, D. Bracy, and D. B. Lacy. Glucoregulation during rest and exercise in depancreatized dogs: role of the acute presence of insulin. Am. J. Physiol. Endocrinol. Metab. 262: E574-E582, 1992.
26. Wasserman, D. H., and A. D. Cherrington. Regulation of extrahepatic fuel sources during exercise. In: Handbook of Physiology. Bethesda, MD: Am. Physiol. Soc., 1996.
27. Wasserman, D. H., J. L. Johnson, J. L. Bupp, D. B. Lacy, and D. P. Bracy. Regulation of gluconeogenesis during rest and exercise in the depancreatized dog. Am. J. Physiol. Endocrinol. Metab. 265: E51-E60,1993.
28. Wasserman, D. H., H. L. A. Lickley, and M. Vranic. Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. J. Clin. Invest. 74: 1404-1413, 1984.
29. Wasserman, D. H., H. L. A. Lickely, and M. Vranic. Important role of glucagon during exercise in diabetic dogs. J. Appl. Physiol. 59: 1272-1281, 1985.
30. Wasserman, D. H., H. L. A. Lickley, and M. Vranic. The role of β-adrenergic mechanisms during exercise in poorly-controlled diabetes. J. Appl. Physiol. 59: 1282-1289, 1985.
31. Wasserman, D. H., J. S. Spalding, D. B. Lacy, C. A. Colburn, R. E. Goldstein, and A. D. Cherrington. Glucagon is a primary controller of the increments in hepatic glycogenolysis and gluconeogenesis during exercise. Am. J. Physiol. Endocrinol. Metab. 257: E108-E117, 1989.