Molecular dynamics simulations of bovine cathepsin B and its complex with CA074

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 4, 2000, Pages 480-485

  Yamamoto, Atsushi ^a   Tomoo, Koji ^a   Miyagawa, Hiroo ^b   Takaoka, Yuji ^b   Sumiya, Shigeyuki ^b   Kitamura, Kunihiro ^b   Ishida, Toshimasa ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Bovine cathepsin B; CA074; Conformational fluctuation; Inhibitory mechanism; Molecular dynamics simulation; Substrate specificity

Indexed keywords

CARBOXYL GROUP; CATHEPSIN B; CYSTEINE; ENZYME INHIBITOR; HISTIDINE; IMIDAZOLE DERIVATIVE; OXYGEN;

AQUEOUS SOLUTION; ARTICLE; DISULFIDE BOND; ENZYME CONFORMATION; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR STABILITY; X RAY ANALYSIS;

EID: 0034018153     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.480     Document Type: Article

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