Acamprosate and relapse prevention in the treatment of alcohol dependence: A placebo-controlled study

Alcohol and Alcoholism

Volumn 35, Issue 2, 2000, Pages 202-209

  Tempesta, Enrico ^a   Janiri, Luigi ^a,d   Bignamini, Angelo ^b   Chabac, Sylvie ^c   Potgieter, Adriaan ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b c/o HyperPhar ^*  (France)

^c Merck Lipha   (France)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACAMPROSATE; ALCOHOL;

ABSTINENCE; ADULT; AGED; ALCOHOLISM; ANXIETY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DETOXIFICATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRINKING BEHAVIOR; EPIGASTRIC PAIN; FOLLOW UP; HEADACHE; HUMAN; LEG EDEMA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OUTPATIENT CARE; PATIENT COUNSELING; PRIORITY JOURNAL; PRURITUS; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SELF HELP; STATISTICAL ANALYSIS;

EID: 0034018047     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/alcalc/35.2.202     Document Type: Article

References (24)

1. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. American Psychiatric Association, Washington, DC.
2. Anton, R. F., Moak, D. H. and Latham, P. K. (1996) The obsessive compulsive drinking scale: A new method of assessing outcome in alcoholism treatment studies. Archives of General Psychiatry 53, 225-231.
3. Emrick, C. D., Tonigan, J. S., Montgomery, H. and Little, L. (1993) Alcoholics Anonymous: what is currently known? In Research on Alcoholics Anonymous: Opportunities and Alternatives, McCrady, B. S. and Miller, W. R. eds, pp. 41-78. Rutgers Center of Alcohol Studies New Brunswick, NJ.
4. Ewing, J. A. (1984) Detecting alcoholism: the CAGE questionnaire. Journal of the American Medical Association 252, 1905-1907.
5. Gerra, G., Caccavari, R., Delsignore, R., Bocchi, R., Fertonani, G. and Passeri, M. (1992) Effects of fluoxetine and Ca-acetyl-homotaurinate on alcohol intake in familial and non-familial alcoholic patients. Current Therapy Research 52, 291-295.
6. Gillings, D. and Koch, G. (1991) The application of the principle of intention to treat to the analysis of clinical trial. Drug Information Journal 25, 411-424.
7. Guy, W. (1996) ECDEU Assessment Manual for Psychopharmacology. National Institute of Mental Health, Rockville, MD. Archives of General Psychiatry 53, 76-338.
8. Hamilton, M. (1959) The assessment of anxiety by rating. British Journal of Medical Psychology 32, 50-55.
9. Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278-296.
10. Hillemand, B., Lhuintre, J. P., Boismare, F., Daoust, M. and Moore, N. (1984-1985) Premier essai favorable du N bis acétylhomotaurinate de calcium (Aota Ca) dans le traitement de l'alcoolodépendant. La Revue de L'Alcoolisme 30, 204-212.
11. Lehert, P. (1993) Review and discussion of statistical analysis of controlled clinical trials in alcoholism. Alcohol and Alcoholism 28 (Suppl. 2), 157-163.
12. Lhuintre, J. P., Moore, N. D., Tran, G., Steru, L., Langrenon, S., Daoust, M., Parot, P., Ladure, P., Libert, C., Boismare, F. and Hillemand, B. (1990) Acamprosate appears to decrease alcohol intake in weaned alcoholics. Alcohol and Alcoholism 25, 613-622.
13. Littleton, J. (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90, 1179-1188.
14. Miller, W. R. and Hester, R. K. (1986) The effectiveness of alcoholism treatment methods: what research reveals. In Treating Addictive Behaviors: Process of Change, Miller, W.R. and Heather, N. eds, pp. 121-174. Plenum Press, New York.
15. Paille, F., Guelfi, J. D., Perkins, A. C., Royer, R. J., Steru, L. and Parot, P. (1995) Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol and Alcoholism 30, 239-247.
16. Pattison, E. M. (1979) The selection of treatment modalities for the alcoholic patient. In The Diagnosis and Treatment of Alcoholism, Mendelson, J. H. and Mello, N. K. eds, pp. 127-235. McGraw-Hill, New York.
17. Pelc, I., Le Bon, O., Lehert, P. and Verbanck, P. (1996) Acamprosate in the treatment of alcohol dependence: a 6-month postdetoxification study. In Acamprosate in Relapse Prevention of Alcoholism, Soyka, M. ed., pp. 133-142. Springer-Verlag, Berlin.
18. Pelc, I., Verbanck, P., Le Bon, O., Gavrilovic, M., Lion, K. and Lehert, P. (1997) Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients: a 90-day placebo-controlled dose-finding study. British Journal of Psychiatry 171, 73-77.
19. Pettinati, H. M., Payne Beiden, P., Evans, B. D., Ruetsch, C. R., Meyers, K. and Jensen, J. M. (1996) The natural history of outpatient alcohol and drug abuse treatment in a private healthcare setting. Alcoholism: Clinical and Experimental Research 20, 847-852.
20. Poldrugo, F. (1997) Acamprosate treatment in a long-term community-based alcohol rehabilitation programme. Addiction 92, 1537-1546.
21. Sass, H., Soyka, M., Mann, K. and Zieglgänsberger, W. (1996) Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Archives of General Psychiatry 53, 673-680.
22. Selzer, M. L. (1971) The Michigan alcoholism screening test: the quest for a new diagnostic instrument. American Journal of Psychiatry 127, 1653-1658.
23. Whitworth, A., Fischer, F., Lesch, O. M., Nimmerrichter, A., Oberbauer, H., Platz, T., Potgieter, A., Walter, H. and Fleishhacker, W.W. (1996) Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet 347, 1438-1442.
24. Zeise, M. L., Kasparov, S., Capogna, M. and Zieglgänsberger, W. (1993) Acamprosate (calcium acetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors. European Journal of Pharmacology 231, 47-52.