Inhibitory effect of PACAP(6-38) on relaxations induced by PACAP, VIP and non-adrenergic, non-cholinergic nerve stimulation in the guinea-pig taenia caeci

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 361, Issue 5, 2000, Pages 492-497

  Lenard Jr L ^a   Lazar Z ^a   Benko R ^a   Szigeti, R ^a   Bathori Z ^a   Toth G K ^b   Penke, B ^b   Bartho L ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Non adrenergic non cholinergic (NANC) relaxation; PACAP antagonist; Pituitary adenylate cyclase activating polypeptide (PACAP); Taenia caeci (guinea pig); Vasoactive intestinal polypeptide (VIP); VIP antagonist

Indexed keywords

APAMIN; ATROPINE; GUANETHIDINE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; ISOPRENALINE; N(G) NITROARGININE; POTASSIUM CHANNEL; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SPANTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CECUM TENIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; INTESTINE INNERVATION; MALE; NERVE STIMULATION; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; SMOOTH MUSCLE RELAXATION; TACHYPHYLAXIS;

ANIMALS; DRUG INTERACTIONS; ENZYME INHIBITORS; FEMALE; GUINEA PIGS; MALE; MUSCLE RELAXATION; NEUROPEPTIDES; NITRIC OXIDE SYNTHASE; NITROARGININE; PEPTIDE FRAGMENTS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0034018016     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000225     Document Type: Article

References (37)

1. Arimura A (1992) Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul Pept 37:287-303
2. Barthó L, Lénárd L Jr, Szigeti R (1998) Nitric oxide and ATP comediate the NANC relaxant response in the guinea-pig taenia caeci. Naunyn-Schmiedeberg's Arch Pharmacol 358:496-499
3. 2 purinoceptors and capsaicin-sensitive afferents in the intestine and other tissues. Eur J Pharmacol 375:203-210
4. Burnstock G, Campbell G, Rand MJ (1966) The inhibitory innervation of the taenia of the guinea-pig caecum. J Physiol (Lond) 182:504-526
5. Chakder S, Rattan S (1998) Involvement of pituitary adenylate cyclase activating peptide in opossum internal anal sphincter relaxation. Am J Physiol 275:G769-G777
6. Cohen ML, Landry AS (1980) Vasoactive intestinal polypeptide: increased tone, enhancement of acetylcholine release and stimulation of adenylate cyclase in intestinal smooth muscle. Life Sci 26:811-822
7. Dockray GJ (1994) Physiology of enteric neuropeptides. In: Johnson LR (ed) Physiology of the gastrointestinal tract, vol 1, 3rd edn. Raven, New York, pp 169-209
8. Fahrenkrug J (1989) VIP and autonomie neurotransmission. Pharmacol Ther 41:515-534
9. Fahrenkrug J (1993) Transmitter role of vasoactive intestinal peptide. Pharmacol Toxicol 72:354-363
10. Furness JB, Pompolo S, Shuttleworth CWR, Burleigh DE (1992) Light-and electron-microscopic immunochemical analysis of nerve fibre types innervating the taenia of the guinea-pig caecum. Cell Tissue Res 270:125-137
11. Grider JR, Rivier JR (1990) Vasoactive intestinal peptide (VIP) as transmitter of inhibitory motor neurons of the gut: evidence from the use of selective VIP antagonists and VIP antiserum. J Pharmacol Exp Ther 253:738-742
12. Grider JR, Cable MB, Bitar KN, Said SI, Makhlouf GM (1985) Vasoactive intestinal peptide. Relaxant neurotransmitter in the taenia coli of the guinea-pig. Gastroenterology 89:36-42
13. Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, Rawlings SR, Robberecht P, Said AI, Sreedharan SP, Wank SA, Waschek JA (1998) International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide. Pharmacol Rev 50:265-270
14. Heinemann Á, Holzer P (1999) Stimulant action of pituitary adenylate cyclase activating peptide on normal and drug-compromised peristalsis in the guinea-pig intestine. Br J Pharmacol 127:763-771
15. Jin JG, Katsoulis S, Schmidt WE, Grider JR (1994) Inhibitory transmission in tenia coli mediated by distinct vasoactive intestinal peptide and apamin-sensitive pituitary adenylate cyclase activating peptide receptors. J Pharmacol Exp Ther 270: 433-439
16. Katsoulis S, Clemens A, Schwörer H, Creutzfeldt W, Schmidt WE (1993a) Pituitary adenylate cyclase activating peptide (PACAP) is a potent relaxant of the rat ileum. Peptides 14:587-592
17. Katsoulis S, Clemens A, Schwörer H, Creutzfeldt W, Schmidt WE (1993b) PACAP is a stimulator of neurogenic contraction in guinea-pig ileum. Am J Physiol 265:G295-G302
18. + channels. Br J Pharmacol 119:623-630
19. Matsueda GR, Stewart JM (1981) A paramethylbenzhydrylamine resin for improved solid-phase synthesis of peptide amides. Peptides 2:45-50
20. McConalogue K, Furness JB, Vremec MA, Hoist JJ, Tornoe K, Marley PD (1995a) Histochemical, pharmacological, biochemical and chromatographic evidence that pituitary adenylyl cyclase activating peptide is involved in inhibitory neurotransmission in the taenia of the guinea-pig caecum. J Auton Nerv Syst 50:311-322
21. McConalogue K, Lyster DJK, Furness JB (1995b) Electrophysiological analysis of the actions of pituitary adenylyl cyclase activating peptide in the taenia of the guinea-pig caecum. Naunyn-Schmiedeberg's Arch Pharmacol 352:538-544
22. McLaren GJ, Lambrecht G, Mutschler E, Bäumert HG, Sneddon P, Kennedy C (1994) Investigation of the effects of PPADS, a novel P2x purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br J Pharmacol 111:913-917
23. Merrifield RB (1963) The synthesis of a tetrapeptide. Solid phase peptide synthesis. J Am Chem Soc 85:2149-2154
24. Motomura Y, Chijiiwa Y, Iwakiri Y, Ochiai T, Nawata Y (1998) Interactive mechanisms among pituitary adenylate cyclase activating peptide, vasoactive intestinal peptide, and parathyroid hormone receptors in guinea-pig cecal circular smooth muscle cells. Endocrinology 139:2869-2878
25. Mungan Z, Arimura A, Ertan A, Rossowski WJ, Coy DH (1992) Pituitary adenylate cyclase activating polypeptide relaxes rat gastrointestinal smooth muscle. Scand J Gastroenterol 27:375-380
26. Pang PK, Kline LW (1998) Protein kinase C mediates the contractile action of pituitary adenylate cyclase activating polypeptide in guinea-pig gallbladder strips. Regul Pept 77:69-76
27. Portbury AE, McConalogue K, Furness JB, Young HM (1995) Distribution of pituitary adenylyl cyclase activating peptide (PACAP) immunoreactivity in neurons of the guinea-pig digestive tract and their projections in the ileum and colon. Cell Tissue Res 279:385-392
28. Rattan S, Chakder S (1997) Excitatory and inhibitory actions of pituitary adenylate cyclase activating peptide (PACAP) in the internal anal sphincter muscle: sites of actions. J Pharmacol Exp Ther 283:722-728
29. Sakakibara S, Shimonishi Y, Kishida Y, Okada M, Sugihara K (1967) Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride. Bull Chem Soc Jpn 40:2164-2167
30. Schwarzhoff R, Schwörer H, Fornefeld H, Morys-Wortmann C, Katsoulis S, Creutzfeldt W, Folsch UR, Schmidt WE (1995) Specific monoclonal antibodies neutralize the action of PACAP 1-27 or PACAP 1-38 on intestinal muscle strips in vitro. Regul Pept 55:57-66
31. Schwörer H, Katsoulis S, Creutzfeldt W, Schmidt WE (1992) Pituitary adenylate cyclase activating peptide, a novel VIP-like gut-brain peptide, relaxes the guinea-pig taenia caeci via apamin-sensitive potassium channels. Naunyn-Schmiedeberg's Arch Pharmacol 346:511-514
32. Shuttleworth CWR, Sweeney KM, Sanders KM (1999) Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig coecum. Br J Pharmacol 127: 1495-1501
33. Sundler F, Ekblad E, Absood A, Håkanson R, Köves K, Arimura A (1992) Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut. Neuroscience 46:439-454
34. Szolcsányi J, Barthó L (1979) Capsaicin-sensitive innervation of the guinea-pig taenia caeci. Naunyn-Schmiedeberg's Arch Pharmacol 309:77-82
35. Vigne P, Pacaud P, Urbach V, Feolde E, Breittmayer JP, Frelin C (1996) The effect of PPADS as an antagonist of inositol (1,4,5) trisphosphate induced intracellular calcium mobilization. Br J Pharmacol 119:360-364
36. Williams JT, North RA (1979) Vasoactive intestinal polypeptide excites neurones of the myenteric plexus. Brain Res 155:174-177
37. Windscheif U, Pfaff O, Ziganshin AU, Hoyle CHV, Bäumert HG, Mutschier E, Burnstock G, Lambrecht G (1995) Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical stimulation in guinea-pig taenia coli and rat duodenum. Br J Pharmacol 115:1509-1517