Intrathecal baclofen for intractable cerebral spasticity: A prospective placebo-controlled, double-blind study

Neurosurgery

Volumn 46, Issue 3, 2000, Pages 603-612

  Van Schaeybroeck, Patrick ^a,b   Nuttin, Bart ^a   Lagae, Lieven ^a   Schrijvers, Els ^a   Borghgraef, Claire ^a   Feys, Peter ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Cerebral palsy; Intrathecal baclofen therapy; Movement disorders; Spasticity

Indexed keywords

BACLOFEN; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; BOLUS INJECTION; CEREBRAL PALSY; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; MALE; MOTOR DYSFUNCTION; MUSCLE FUNCTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPASTICITY;

EID: 0034017473     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-200003000-00017     Document Type: Article

References (21)

1. Albright AL: Spastic cerebral palsy: Approaches to drug treatment. CNS Drugs 4:17-27, 1995.
2. Albright AL: Intrathecal baclofen in cerebral palsy movement disorders. J Child Neurol 11[Suppl 1]:S29-S35, 1996.
3. Albright AL, Barron WB, Fasick MP, Polinko P, Janosky J: Continuous intrathecal baclofen infusion for spasticity of cerebral origin. JAMA 270:2475-2477, 1993.
4. Albright AL, Barry MJ, Fasick P, Barron W, Shultz B: Continuous intrathecal baclofen infusion for symptomatic generalized dystonia. Neurosurgery 38:934-939, 1996.
5. Albright AL, Barry MJ, Fasick P, Janosky J: Effects of continuous intrathecal baclofen infusion and selective posterior rhizotomy on upper extremity spasticity. Pediatr Neurosurg 23:82-85, 1995.
6. Albright AL, Barry MJ, Painter MJ, Shultz B: Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy. J Neurosurg 88:73-76, 1998.
7. Albright AL, Cervi A, Singletary J: Intrathecal baclofen for spasticity in cerebral palsy. JAMA 265:1418-1422, 1991.
8. Armstrong RW, Steinbok P, Douglas Cochrane D, Kube SD, Fife SE, Farrell K: Intrathecally administered baclofen for treatment of children with spasticity of cerebral origin. J Neurosurg 87:409-414, 1997.
9. Ashworth B: Preliminary trial of carisoprodol in multiple sclerosis. Practitioner 192:540-542, 1964.
10. Becker R, Alberti O, Bauer BL: Continuous intrathecal baclofen infusion in severe spasticity after traumatic or hypoxic brain injury. J Neurol 244:160-166, 1997.
11. Campbell SK: Quantifying the effects of interventions for movement disorders resulting from cerebral palsy. J Child Neurol 11[Suppl 1]:S61-S70, 1996.
12. Coffey JR, Cahill D, Steers W, Park TS, Ordia J, Meythaler J, Herman R, Shetter AG, Levy R, Gill B, Smith R, Wilberger J, Loeser JD, Chabal C, Feler C, Robertson JT, Penn RD, Clarke A, Burchiel KJ, Leibrock LG: Intrathecal baclofen for intractable spasticity of spinal origin: Results of a long-term multicenter study. J Neurosurg 78:226-232, 1993.
13. Ford B, Greene P, Louis ED, Petzinger G, Bressman SB, Goodman R, Brin MF, Sadiq S, Fahn S: Use of intrathecal baclofen in the treatment of patients with dystonia. Arch Neurol 53:1241-1246, 1996.
14. Gerszten PC, Albright AL, Johnstone GF: Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy. J Neurosurg 88:1009-1013, 1998.
15. Gracies JM, Nance P, Elovic E, McGuire J, Simpson DM: Traditional pharmacological treatments for spasticity: Part II - General and regional treatments. Muscle Nerve Suppl 6:S92-S120, 1997.
16. Meythaler JM, McCary A, Hadley MN: Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: A preliminary report. J Neurosurg 87:415-419, 1997.
17. Muller H: Treatment of severe spasticity: Results of a multicenter trial conducted in Germany involving the intrathecal infusion of baclofen by an implantable drug delivery system, in Lakke JPWF (ed): Parenteral Drug Therapy in Spasticity and Parkinson's Disease. Park Ridge, Parthenon, 1992, pp 103-113.
18. Penn RD, Kroin J: Intrathecal baclofen alleviates spinal cord spasticity. Lancet 1:1078, 1984 (letter).
19. Penn RD, Kroin JS: Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg 66:181-185, 1987.
20. Penn RD, Gianino JM, York MM: Intrathecal baclofen for motor disorders. Mov Disord 10:675-677, 1995.
21. Pierson SH: Outcome measures in spasticity management. Muscle Nerve Suppl 6:S36-S60, 1997.