Hydroxyurea treatment reduces haematopoietic progenitor growth and CD34 positive cells in polycythaemia vera and essential thrombocythaemia

European Journal of Haematology

Volumn 64, Issue 3, 2000, Pages 188-193

  Andréasson, Björn ^a,c   Swolin, Birgitta ^b   Kutti, Jack ^a,b  

^a Department of Medicine   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UDDEVALLA HOSPITAL   (Sweden)

Author keywords

CD34+ cells; Endogenous erythroid colonies; Essential thrombocythaemia; Hydroxyurea; Polycythaemia vera

Indexed keywords

CD34 ANTIGEN; ERYTHROPOIETIN; HYDROXYUREA;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW SUPPRESSION; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; HEMATOPOIETIC STEM CELL; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; PHLEBOTOMY; POLYCYTHEMIA VERA; PRIORITY JOURNAL; THROMBOCYTHEMIA; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD34; CELL DIVISION; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; ERYTHROPOIETIN; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; HYDROXYUREA; MALE; MIDDLE AGED; PHLEBOTOMY; POLYCYTHEMIA VERA; THROMBOCYTHEMIA, HEMORRHAGIC;

EID: 0034017449     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2000.90052.x     Document Type: Article

References (18)

1. 1. BERLIN NI. Diagnosis and classification of the polycythaemias. Semin Hematol 1975;12:339-351.
2. 2. BERK PD, GOLDBERG JD, DONOVAN PB, FRUCHTMAN SM, BERLIN NI, WASSERMAN LR. Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin Hematol 1986;23:132-143.
3. 3. MURPHY S, ILAND H, ROSENTHAL D, LASZLO J. Essential thrombocythemia: an interim report from the Polycythemia Vera Study Group. Semin Hematol 1986;23:177-182.
4. 4. PEARSON TC, MESSINEZY M. The diagnostic criteria of polycythaemia rubra vera. Leuk Lymphoma 1996;22(suppl 1):87-93.
5. 5. KUTTI J, WADENVIK H. Diagnostic and differential criteria of essential thrombocythemia and reactive thrombocythosis. Leuk Lymphoma 1996;22(suppl 1):41-45.
6. 6. LACOMBE C, CASADEVALL N, VARET B. Polycythaemia vera: in vitro studies of circulating erythroid progenitors. Br J Haematol 1980;42:189-199.
7. 7. YUEN E, GIBSON J, RICKARD KA, KRONENBERG H. An analysis of peripheral blood burst forming units erythroid in the polycythaemic states. Scand J Haematol 1983;31: 293-297.
8. 8. ERIDANI S, SAWYER B, PEARSON TC. Patterns of in vitro BFU-E proliferation in different forms of polycythaemia and in thrombocythaemia. Eur J Haematol 1987;38:363-369.
9. 9. JUVONEN E, IKKALA E, OKSANEN K, RUUTU T. Megakaryocyte and erythroid colony formation in essential thrombocythaemia and reactive thrombocytosis: diagnostic value and correlation to complications. Br J Haematol 1993;83: 192-197.
10. 10. CASTELLO G, LERZA R, CERRUTI A, CAVALLINI D, BOGLIOLO G, PANNACCIULLI I. The in vitro and in vivo effect of recombinant interferon alpha-2a on circulating haemotopoietic progenitors in polycythaemia vera. Br J Haematol 1994; 87:621-623.
11. 11. CASTELLO G, LERZA R, CERRUTI A, CAVALLINI D, BOGLIOLO G, PANNACCIULLI I. Circulating hematopoietic progenitor cells in polycythemia vera: the in vivo effect of hydroxyurea. Ann Hematol 1995;71:119-121.
12. 12. ANDRÉASSON B, SWOLIN B, KUTTI J. Increase of CD34 positive cells in polycythaemia vera. Eur J Haematol 1997;59: 171-176.
13. + cell analysis: technical recommendations for progenitor cell enumeration in leucapheresis from multiple myeloma patients. Nordic Myeloma Study Group Laboratories. J Hematother 1995;4:21-28.
14. 14. GREGORY CJ, EAVES AC. Human marrow cells capable of erythropoietic differentiation in vitro; definition of three erythroid colony responses. Blood 1977;49:855-864.
15. 15. CARNESKOG J, KUTTI J, WADENVIK H, LUNDBERG PA, LINDSTEDT G. Plasma erythropoietin by high-detectability immunoradiometric assay in untreated and treated patients with polycythaemia vera and essential thrombocythaemia. Eur J Haematol 1998;60:278-282.
16. 16. PARTANEN S, JUVONEN E, IKKALA E, RUUTU T. Spontaneous erythroid colony formation in differential diagnosis of erythrocytosis. Eur J Haematol 1989;42:327-330.
17. 17. FLORESA L, BESSES C, ALMARCHA J, et al. Circulating erythroid and megakaryocytic progenitors in polycythaemia vera and essential thrombocythaemia. Eur J Haematol 1989;43: 417-422.
18. 18. ANDRÉASSON B, CARNESKOG J, LINDSTEDT G, et al. Plasma erythropoietin concentrations in polycythaemia vera: with special reference to myelosuppressive therapy. Leuk Lymphoma 1999; in press.