The 3-epi- and 24-oxo-derivatives of 1α,25 dihydroxyvitamin D3 stimulate transcription through the vitamin D receptor

Journal of Steroid Biochemistry and Molecular Biology

Volumn 72, Issue 1-2, 2000, Pages 29-34

  Messerlian, Serge ^a   Gao, Xiangming ^a   St Arnaud, René ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Vitamin D metabolites; Vitamin D receptor; Vitamin D response element (VDRE)

Indexed keywords

24 OXOCALCITRIOL; 25 HYDROXYVITAMIN D 24 HYDROXYLASE; 3 EPICALCITRIOL; CALCITRIOL; CALCITRIOL 26,23 LACTONE; CALCITRIOL DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN CACO 2; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG ACTIVITY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PROMOTER REGION; VITAMIN D METABOLISM;

ANIMALS; CALCITRIOL; CELL LINE; CULTURE MEDIA, SERUM-FREE; CYTOCHROME P-450 ENZYME SYSTEM; GENES, REPORTER; HUMANS; MUTATION; OSTEOCALCIN; PROMOTER REGIONS (GENETICS); RECEPTORS, CALCITRIOL; RESPONSE ELEMENTS; STEROID HYDROXYLASES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION; VITAMIN D;

EID: 0034017239     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(99)00148-X     Document Type: Article

References (21)

1. Holick M.F. Vitamin D: photobiology, metabolism, and clinical applications. DeGroot L., Besser H., Burger H.G. Endocrinology. 3rd ed. 1995;990-1013 Saunders, Philadelphia.
2. DeLuca H. The vitamin D story: a collaborative effort of basic science and clinical medicine. Fed. Proc. Am. Soc. Exper. Biol. 2:1988;224-236.
3. Reichel H., Koeffler H.P., Norman A.W. The role of the vitamin D endocrine system in health and disease. N. Engl. J. Med. 320:1989;981-991.
4. Holick M.F. Vitamin D: new horizons for the 21st century. Am. J. Clin. Nutr. 60:1994;619-630.
5. Haussler M.R., Whitfield G.K., Haussler C.A., Hsieh J.-C., Thompson P.D., Selznick S.H., Dominguez C.E., Jurutka P.W. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J. Bone Miner. Res. 13:1998;325-349.
6. Bouillon R., Okamura W.H., Norman A.W. Structure-function relationships in the vitamin D endocrine system. Endocrine Rev. 16:1995;200-257.
7. Bischof M.G., Siu-Caldera M.-L., Weiskopf A., Vouros P., Cross H.S., Peterlik M., Reddy G.S. Differentiation-related pathways of 1α,25-dihydroxycholecalciferol metabolism in human colon adenocarcinoma-derived Caco-2 cells: production of 1α,25-dihydroxy-3-epi-cholecalciferol. Exp. Cell Res. 241:1998;194-201.
8. 3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation. Biochem. J. 262:1989;173-180.
9. 3 have direct bone-resorbing activity. Arch. Biochem. and Biophys. 230:1984;424-429.
10. 3 analogs and their 24-oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects. J. Cell. Biochem. 66:1997;413-425.
11. Jones G. Analog metabolism. Feldman D., Glorieux F.H., Pike J.W. Vitamin D. 1997;973-994 Academic Press, San Diego.
12. 3-26,23-lactone in the rat. J. Steroid Biochem. 20:1984;611-615.
13. Ishizuka S., Norman A.W. The difference of biological activity among four diastereoisomers of 1α,25-dihydroxycholecalciferol-26,23-lactone. J. Steroid Biochem. 25:1986;505-510.
14. Candeliere G.A., Prud'homme J., St-Arnaud R. Differential stimulation of fos and jun family members by calcitriol in osteoblastic cells. Mol. Endocrinol. 5:1991;1780-1788.
15. Rudnicki M.A., Reuhl K.R., McBurney M.W. Cell lines with developmental potential restricted to mesodermal lineages isolated from differentiating cultures of pluripotential P19 embryonal carcinoma cells. Development. 107:1989;361-372.
16. 3 24-hydroxylase (CYP24) promoter. J. Biol. Chem. 271:1996;29715-29721.
17. Brown A.J., Slatopolsky E.S. Mechanisms for the selective actions of vitamin D analogs. Feldman D., Glorieux F.H., Pike J.W. Vitamin D. 1997;995-1009 Academic Press, San Diego.
18. Mangelsdorf D.J., Evans R.M. The RXR heterodimers and orphan receptors. Cell. 83:1995;841-850.
19. Forman B.M., Tzameli I., Choi H.-S., Chen J., Simha D., Seol W., Evans R.M., Moore D.D. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β Nature. 395:1998;612-615.
20. Blumberg B., Sabbagh W. Jr, Juguilon H., Bolado J. Jr, van Meter C.M., Ong E.S., Evans R.M. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes & Dev. 12:1998;3195-3205.
21. 3. Past, present and future. J. Bone Miner. Res. 13:1998;1360-1369.