Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: A model for achieving, durable porcine hematopoietic chimerism across an extensive xenogeneic barrier

Xenotransplantation

Volumn 7, Issue 1, 2000, Pages 58-64

  Yang, Yong Guang ^a,c   Chen, Ann M ^a   Garrett, Lisa J ^b   Sergio, Justin J ^a   Theodore, Pierre ^a   Awwad, Michel ^c   VerHalen, Jon ^a   Bodine, David M ^b   Sachs, David H ^a   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c BioTransplant Inc   (United States)

Author keywords

Bone marrow transplantation; Cytokine; Hematopoietic chimerism; Transgenics; Xenotransplantation

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMATOPOIESIS; HEMATOPOIETIC CELL; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; TRANSGENE; TRANSGENIC MOUSE; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELLS, CULTURED; CHIMERA; CYTOKINES; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; HEMATOPOIESIS; MICE; MICE, SCID; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; SWINE; TRANSGENES; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034017153     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3089.2000.00044.x     Document Type: Article

References (31)

1. SYKES M, LEE LA, SACHS DH. Xenograft tolerance. Immunol Rev 1994; 141: 245.
2. DORLING A, LECHLER R. T cell-mediated xenograft rejection: Specific tolerance is probably required for long term xenograft survival. Xenotransplantation 1998; 5: 234.
3. MAYUMI H, GOOD RA. Long-lasting skin allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigen barriers by a tolerance-inducing method using cyclophosphamide. J Exp Med 1989; 169: 213.
4. SHARABI Y, SACHS DH. Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen. J Exp Med 1989; 169: 493.
5. SHARABI Y, AKSENTIJEVICH I, Sundt III, TM, SACHS DH, SYKES M. Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen. J Exp Med 1990; 172: 195.
6. SINGER A, HATHCOCK KS, HODES RJ. Self recognition in allogeneic radiation chimeras. A radiation resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells. J Exp Med 1981; 153: 1286.
7. KAWAI T, COSIMI AB, COLVIN RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomologous monkeys. Transplantation 1995; 59: 256.
8. WANG B-Y, CHERRY, EL-BADRI NS, GOOD RA. Prevention of development of autoimmune disease in BXSB mice by mixed bone marrow transplantation. Proc Natl Acad Sci USA 1997; 94: 12065.
9. YANG Y-G, DEGOMA E, OHDAN H, et al. Tolerization of anti-Galα1-3Gal natural antibody-forming B cells by induction of mixed chimerism. J Exp Med 1998; 187: 1335.
10. GRITSCH HA, SYKES M. Host marrow has a competitive advantage which limits donor hematopoietic repopulation in mixed xenogeneic chimeras. Xenotransplantation 1996; 3: 312.
11. GRITSCH HA, GLASER RM, EMERY DW, et al. The importance of non-immune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation 1994; 57: 906.
12. YANG Y-G, GLASER RM, MONROY R, SWENSON K, SYKES M. Enhanced porcine hematopoiesis in mice receiving donor-specific interleukin-3. Transplant Proc 1996; 28: 655.
13. YANG Y-G, SERGIO JJ, SWENSON K, GLASER RM, MONROY R, SYKES M. Donor-specific growth factors promote swine hematopoiesis in SCID mice. Xenotransplantation 1996; 3: 92.
14. YANG Y-G, SERGIO JJ, SYKES M. Engraftment of discordant xenogeneic swine bone marrow cells in immunodeficient mice. Xenotransplantation 1997; 4: 235.
15. BOCK TA, ORLIC D, DUNBAR CE, BROXMEYER HE, BODINE DM. Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes. J Exp Med 1995; 182: 2037.
16. α mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase. J Bio Chem 1990; 265: 21317.
17. HAWLEY RJ, ABRAHAM S, AKIYOSHI DE, et al. Xenogeneic bone marrow transplantation: I. Cloning, expression, and species specificity of porcine IL-3 and granulocyte-macrophage colony-stimulating factor. Xenotransplantation 1997; 4: 103.
18. GIOVINO MA, HAWLEY RJ, DICKERSON WM, et al. Xenogeneic bone marrow transplantation: II. Porcine-specific growth factors enhance porcine bone marrow engraftment in an in vitro primate microenvironment. Xenotransplantation 1997; 4: 112.
19. PENNINGTON LR, SAKAMOTO K, POPITZ-BERGEZ F, et al. Bone marrow transplantation in miniature swine. I. Development of the model. Transplantation 1988; 45: 21.
20. YANG Y-G, CHEN AM, SERGIO JJ, ZHOU Y, SYKES M. Role of antibody-independent complement activation in rejection of porcine bone marrow cells in mice. Transplantation 2000; 69: 163.
21. LUNNEY JK, PESCOVITZ MD. Phenotypic and functional characterization of pig lymphocyte population. Vet Immunol Immunopath 1987; 17: 135.
22. UNKELESS JC. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med 1979; 150: 580.
23. KOLLMAN TR, KIM A, ZHUANG X, HACHAMOVITCH M, GOLDSTEIN H. Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines. Proc Natl Acad Sci USA 1994; 91: 8032.
24. BHATIA M, BONNET D, MURDOCH B, GAN OI, DICK JE. A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nature Med 1998; 4: 1038.
25. DICK JE, LAPIDOT T, PFLUMIO F. Transplantation of normal and leukemic human bone marrow into immune-deficient mice: development of animal models for human hematopoiesis. Immunol Rev 1991; 124: 25.
26. KAMEL-REID S, DICK JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 1988; 242: 1706.
27. LAPIDOT T, PFLUMIA F, DOEDENS M, MURDOCH B, WILLIAMS DE, DICK JE. Cytokine stimulation of multi-lineage hematopoiesis from immature human cells engrafted in SCID mice. Science 1992; 255: 1137.
28. NOLTA JA, HANLEY MB, KOHN DB. Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors. Blood 1994; 83: 3041.
29. TOKSOZ D, ZSEBO KM, SMITH KA et al. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci U S A 1992; 89: 7350.
30. FRIEL J, HEBERLEIN C, ITOH K, OSTERTAG W. Role of the stem cell factor (SCF) receptor and the alternative forms of its ligand (SCF) in the induction of long-term growth by stroma cells. Leukemia 1997; 11: 493.
31. + cells in mice expressing porcine cytokines: Toward tolerance induction across discordant xenogeneic barriers. Transplantation, 2000; in press.