Lack of protection against vertical transmission of HIV-1 by interferons produced during pregnancy in a cohort from east African Republic of Malawi

Journal of Medical Virology

Volumn 61, Issue 2, 2000, Pages 195-200

  Zachar, Vladimir ^a,b   Fazio Tirrozzo, Gabriella ^c   Fink, Trine ^a   Roberts, Drucilla J ^d   Broadhead, Robin L ^e   Brabin, Bernard ^c,f   Ebbesen, Peter ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b INSTITUTE OF VIROLOGY   (Slovakia)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF MALAWI   (Malawi)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Innate immunity; Perinatal infection; Placenta

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; INTERFERON;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNITY; MACROPHAGE; MALAWI; MATERNAL SERUM; NONHUMAN; PERINATAL INFECTION; PREGNANCY; TROPHOBLAST; UMBILICAL CORD BLOOD; VERTICAL TRANSMISSION; VIRUS TRANSMISSION;

CHORIONIC VILLI; COHORT STUDIES; DISEASE TRANSMISSION, VERTICAL; FEMALE; FETAL BLOOD; HIV INFECTIONS; HIV SEROPOSITIVITY; HIV-1; HUMANS; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; INFANT; INTERFERONS; MACROPHAGES; MALAWI; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034015998     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(200006)61:2<195::AID-JMV4>3.0.CO;2-A     Document Type: Article

References (26)

1. Aboagye-Mathiesen G, Toth FD, Petersen PM, Gildberg A, Norskov-Lauritsen N, Zachar V, Ebbesen P. 1993. Differential interferon production in human first and third trimester trophoblast cultures stimulated with viruses. Placenta 14:225-234.
2. Bernischke K, Kaufmann P. 1995. Pathology of the human placenta. 3rd Ed. New York: Springer-Verlag. 871 p.
3. Bocci V, Paulesu L, Ricci MG. 1985. The physiological interferon response. IV. Production of interferon by the perfused human placenta at term. Proc Soc Exp Biol Med 180:137-143.
4. Bourinbaiar AS, Krasinski K, Borkowsky W, Lee-Huang S. 1995. Protective effect of interferon-alpha against cell-mediated human immunodeficiency virus transmission resulting from coculture of infected lymphocytes with fetal trophoblasts. J Interferon Cytokine Res 15:503-508.
5. Bulmer JN, Morrison L, Johnson PM, Meager A. 1990. Immunohistochemical localization of interferons in human placental tissues in normal, ectopic, and molar pregnancy. Am J Reprod Immunol 22:109-116.
6. Chard T, Iles R. 1992. Interferon as a fetoplacental signal in pregnancy. In: Miller RK, Thiede HA, editors. Cedard L, Firth A, editors. Placental signals. Autocrine and paracrine control of pregnancy. Trophoblast research. Vol. 6. Rochester, NY: University of Rochester Press. p 55-72.
7. Chard T, Craig PH, Menabawey M, Lee C. 1986. Alpha interferon in human pregnancy. Br J Obstet Gynaecol 93:1145-1149.
8. Coccia EM, Krust B, Hovanessian AG. 1994. Specific inhibition of viral protein synthesis in HIV-infected cells in response to interferon treatment. J Biol Chem 269:23087-23094.
9. Duc-Goiran P, Robert-Galliot B, Lopez J, Chany C. 1985. Unusual apparently constitutive interferons and antagonists in human placental blood. Proc Natl Acad Sci USA 82:5010-5014.
10. Ebbesen P, Hager H, Norskov-Lauritsen N, Aboagye-Mathiesen G, Zdravkovic M, Villadsen J, Liu X, Petersen PM, Bambra C, Nyongo A, et al. 1995. Concurrence of high levels of interferons alpha and beta in cord and maternal blood and simultaneous presence of interferon in trophoblast in an African population. J Interferon Cytokine Res 15:123-128.
11. Fink T. 1997. Human trophoblast IFN-alpha variants: expression and biological characterization. In: Thesis. Institute for Molecular and Structural Biology, University of Aarhus. Aarhus: University of Aarhus. 45 p.
12. Howatson AG, Farquharson M, Meager A, McNicol AM, Foulis AK. 1988. Localization of alpha-interferon in the human feto-placental unit. J Endocr 119:531-534.
13. Khan NU, Gibson A, Foulis AK. 1990. The distribution of immunoreactive interferon-alpha in formalin-fixed paraffin-embedded normal human foetal and infant tissues. Immunology 71:230-235.
14. Lebon P, Girard S, Thepot F, Chany C. 1982. The presence of alpha-interferon in human amniotic fluid. J Gen Virol 59:393-396.
15. Paradowska E, Blach-Olszewska Z, Sender J, Jarosz W. 1996. Antiviral nonspecific immunity of human placenta at term: possible role of endogenous tumor necrosis factors and interferons. J Interferon Cytokine Res 16:941-948.
16. Paradowska E, Blach-Olszewska Z, Gejdel E. 1997. Constitutive and induced cytokine production by human placenta and amniotic membrane at term. Placenta 18:441-446.
17. Paulesu L, Bocci V, King A, Loke YM. 1991. Immunocytochemical localization of interferons in human trophoblast populations. J Biol Regul Homeost Agents 5:81-85.
18. Rivero J, Fraga M, Cancio I, Cuervo J, Lopez-Saura P. 1997. Long-term treatment with recombinant interferon alpha-2b prolongs survival of asymptomatic HIV-infected individuals. Biotherapy 10: 107-113.
19. Roberts RM, Cross JC, Farin CE, Hansen TR, Klemann SW, Imakawa K. 1990. Interferons at the placental interface. J Reprod Fertil 41(suppl):63-74.
20. Skillman DR, Malone JL, Decker CF, Wagner KF, Mapou RL, Liao MJ, Testa D, Meltzer MS. 1996. Phase I trial of interferon alfa-n3 in early-stage human immunodeficiency virus type 1 disease: evidence for drug safety, tolerance, and antiviral activity. J Infect Dis 173:1107-1114.
21. Taguchi F, Kajioka J, Shimada N. 1985. Presence of interferon and antibodies to BK virus in amniotic fluid of normal pregnant women. Acta Virol 29:299-304.
22. Toth FD, Norskov-Lauritsen N, Juhl CB, Aboagye-Mathiesen G, Ebbesen P. 1990. Interferon production by cultured human trophoblasts and choriocarcinoma cell lines induced by Sendai virus. J Gen Virol 71:3067-3069.
23. Tyring SK. 1995. Interferons: biochemistry and mechanisms of action. Am J Obstet Gynecol 172:1350-1353.
24. Whaley AE, Meka CS, Harbison LA, Hunt JS, Imakawa K. 1994. Identification and cellular localization of unique interferon mRNA from human placenta. J Biol Chem 269:10864-10868.
25. Zachar V, Hager H, Koppelhus U, Zacharova V, Liu X, Bambra C, Goustin AS, Ebbesen P. 1997. Elevated interferon-alpha in maternal and umbilical cord blood and in the placental trophoblast suggests natural protection against vertical transmission of HIV-1 in a Kenyan cohort. AIDS 11:383-385.
26. Zdravkovic M, Knudsen HJ, Liu X, Hager H, Zachar V, Aboagye-Mathiesen G, Ebbesen P. 1997. High interferon alpha levels in placenta, maternal, and cord blood suggest a protective effect against intrauterine herpes simplex virus infection. J Med Virol 51:210-213.