Pinacidil suppresses contractility and preserves energy but glibenclamide has no effect during muscle fatigue

American Journal of Physiology - Cell Physiology

Volumn 278, Issue 2 47-2, 2000, Pages

  Matar, W ^a   Nosek, T M ^b,c   Wong, D ^a   Renaud, J M ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Action potential; Adenosine 5' triphosphate; Extensor digitorum longus; Phosphocreatine; Resting potential; Rubidium 86; Skeletal muscle; Tetanic force

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; GLIBENCLAMIDE; PINACIDIL; POTASSIUM CHANNEL; RUBIDIUM 86;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXTENSOR MUSCLE; LEG MUSCLE; MOUSE; MUSCLE CONTRACTILITY; MUSCLE FATIGUE; MUSCLE FORCE; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; SOLEUS MUSCLE;

ANIMALIA;

EID: 0034014610     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.278.2.c404     Document Type: Article

References (14)

1. Adrian, R. H., W. K. Chandler, and A. L. Hodgkin. Voltage clamp experiments in striated muscle fibres. J. Physiol. (Lond.) 208: 607-644, 1970.
2. + channels in mammalian skeletal muscle cells. Eur. J. Pharmacol. 236: 419-426, 1993.
3. 2+ and pH. J. Physiol. (Lond.) 485: 283-296, 1995.
4. Balog, E. M., L. V. Thompson, and R. H. Fitts. Role of sarcolemma action potentials and excitability in muscle fatigue. J. Appl. Physiol. 76: 2157-2162, 1994.
5. ATP channels of mammalian skeletal muscle. J. Membr. Biol. 152: 111-116, 1996.
6. ATP channels in intact mammalian skeletal muscle fibres. Br. J. Pharmacol. 123: 1103-1110, 1998.
7. + effect on contractility of frog sartorius muscle: implication for the mechanism of fatigue. Am. J. Physiol. Cell Physiol. 268: C1528-C1536, 1995.
8. Brotto, M. A. P., R. T. H. Fogaca, T. L. Creazzo, R. E. Godt, and T. M. Nosek. The effect of 2,3-butanedione 2-monoxime (BDM) on ventricular trabeculae from the avian heart. J. Muscle Res. Cell Motil. 16: 1-10, 1995.
9. Castle, N. A., and D. G. Haylett. Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle. J. Physiol. (Lond.) 383: 31-43, 1987.
10. Comtois, A., P. Light, J. M. Renaud, and M. Kong. Tblbutamide, but not glyburide, affects the excitability and contractility of unfatigued frog sartorius muscle. Eur. J. Pharmacol. 242: 65-73, 1993.
11. Comtois, A-, C. Sinderby, N. Comtois, A. Grassino, and J. M. Renaud. An ATP-sensitive potassium channel blocker decreases diaphragmatic circulation in anesthetized dogs. J. Appl. Physiol. 77: 127-134, 1994.
12. + current during hypoxia: correlation with tissue ATP levels. Am. J. Physiol. Heart Circ. Physiol. 261: H671-H676, 1991.
13. Duty, S., and D. G. Allen. The effects of glibenclamide on tetanic force and intracellular calcium in normal and fatigued mouse skeletal muscle. Exp. Physiol. 80: 520-541, 1995.
14. + channels in cardiac muscle. J. Pharmacol. Exp. Ther. 262: 71-79, 1992.