Seizure recurrence after reduction of an antiepileptic drug in patients with unprovoked seizures and severe neurological abnormalities

Psychiatry and Clinical Neurosciences

Volumn 54, Issue 1, 2000, Pages 41-44

  Kimura, Masahiko ^a,b   Yoshino, Kunio ^b   Suzuki, Noriko ^b  

^a SHIMANE UNIVERSITY   (Japan)

^b National Nishitottori Hospital   (Japan)

Author keywords

Antiepileptic drug reduction; Neurological abnormalities

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; PHENOBARBITAL; PRIMIDONE; VALPROIC ACID;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; DRUG WITHDRAWAL; EPILEPSY; FEMALE; HUMAN; MALE; NEUROLOGIC DISEASE; ONSET AGE; RECURRENT DISEASE; RELAPSE; RISK FACTOR; SEIZURE;

ADOLESCENT; ADULT; ANTICONVULSANTS; FEMALE; HUMANS; MALE; NERVOUS SYSTEM DISEASES; PROSPECTIVE STUDIES; RECURRENCE; SEIZURES; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 0034014586     PISSN: 13231316     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1819.2000.00635.x     Document Type: Article

References (12)

1. Emerson R, D'Souza J, Vining EP, Holden KR, Mellit ED, Freeman JM. Stopping medication in children with epilepsy. Predictors of outcome. N. Engl. J. Med. 1981; 304: 1125-1129.
2. Thurston JH, Thurston DL, Hixon BB, Keller AJ. Additional follow-up of 148 children 15-23 years after withdrawal of anticonvulsant therapy. N. Engl. J. Med. 1982; 306: 831-836.
3. Callaghan N, Garrett A, Goggin T. Withdrawal of anticonvulsant drugs in patients free of seizures for two years. N. Engl. J. Med. 1988; 318: 942-946.
4. Matricardi M, Brinciotti M, Benedetti P. Outcome after discontinuation of antiepileptic drug therapy in children with epilepsy. Epilepsia 1989; 30: 582-589.
5. Shinnar S, Berg AT, Moshe SL, Kang H, O'Dell C, Alemany M. Discontinuing antiepileptic drugs in children with epilepsy: a prospective study. Ann. Neurol. 1994; 35: 534-545.
6. Berg AT, Shinnar S. Relapse following discontinuation of antiepileptic drugs: A meta-analysis. Neurology 1994; 44: 601-608.
7. Coulter DL. Withdrawal of barbiturate anticonvulsant drugs; prospective controlled study. Am. J. Ment. Retard. 1988; 93: 320-327.
8. Marcus JC. Stopping antiepileptic therapy in mentally-retarded, epileptic children. Neuropediatrics 1998; 29: 26-28.
9. Lüders H, Lesser RP, Dinner DS, Morris HH. Benign focal epilepsy of childhood. In: Lüders H, Lesser RP (eds), Epilepsy: Electroclinical Syndromes. Springer, Berlin, 1987; 303-346.
10. Aicardi J. Infantile spasms and related syndrome. In: Aicardi J (ed.), Epilepsy in Children. 2nd edn. International Review of Child Neurology Series. Raven Press, New York, 1994; 18-43.
11. Pointdexter AR, Berglund JA, Kolstoe PD. Changes in antiepileptic drug prescribing patterns in large institutions: preliminary results of a five-year experience. Am. J. Ment. Retard. 1993; 98: 34-40.
12. Bennett HS, Dunlop T, Ziring PR. Reduction of polypharmacy for epilepsy in an institution for the retarded. Dev. Med. Child Neurol. 1993; 25: 735-737.