Dose-finding study of oral idarubicin and cyclophosphamide in first-line treatment of elderly patients with metastatic breast cancer

Annals of Oncology

Volumn 11, Issue 2, 2000, Pages 229-230

  Kurtz, J E ^f   Deplanque, G ^g   Borel, C ^a   Mathelin, C ^g   Prevost G ^b   Poulin, G ^c   Barats, J C ^d   Bergerat, J P ^g   Chapelle Marcillac, I ^e   Bardonnet, M ^e   Dufour, P ^g  

^a CENTRE PAUL STRAUSS   (France)

^b CENTRE HOSPITALIER DE MULHOUSE   (France)

^c CENTRE HOSPITALIER   (France)

^d Pasteur Hospital   (France)

^e Laboratoires Pharmacia and Upjohn   (France)

^f UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^g NONE

Author keywords

Breast cancer; Cyclophosphamide; Elderly; Idarubicin; Oral chemotherapy

Indexed keywords

CYCLOPHOSPHAMIDE; IDARUBICIN;

AGED; ALOPECIA; ARTICLE; BONE MARROW TOXICITY; BREAST CANCER; CANCER COMBINATION CHEMOTHERAPY; CLINICAL ARTICLE; DOSE CALCULATION; DRUG TOLERABILITY; FEBRILE NEUTROPENIA; FEMALE; HUMAN; INFECTION; MAXIMUM PERMISSIBLE DOSE; METASTASIS; NAUSEA; PRIORITY JOURNAL; QUALITY OF LIFE; VOMITING;

EID: 0034013782     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008384820279     Document Type: Article

References (9)

1. Breier S, Giangiacomo G, Roffe C et al. Oral (p.o.) chemotherapy of advanced breast cancer with idarubicin (IDA) plus cyclophosphamide (CY). Proc Annu Meet Am Soc Clin Oncol 1996; 15: A197.
2. Casper ES, Raymond V, Hakes TB et al. Phase II evaluation of orally administered idarubicin in patients with advanced breast cancer. Cancer Treat Rep 1987; 71: 1289-90.
3. Chevallier B, Monnier A, Metz R et al. Phase II study of oral idarubicin in elderly patients with advanced breast cancer. Am J Clin Oncol 1990; 13: 436-9.
4. Kolaric K, Mechl Z. Combination of idarubicin and cyclophosphamide administered orally in untreated postmenopausal breast cancer patients. A phase II study. Oncology 1991; 48: 93-6.
5. Lopez M, Contegiacomo A, Vici P et al. A prospective randomized trial of doxorubicin versus idarubicin in the treatment of advanced breast cancer. Cancer 1989; 64 (12): 2431-6.
6. Lopez M, Vici P, Carpano S et al. Combination chemotherapy with oral idarubicin and cyclophosphamide for metastatic breast cancer. J Cancer Res Clin Oncol 1991; 117: 61-4.
7. Richardet E, Bordenave R, Cardoso C et al. Oral idarubicin plus cyclophosphamide in advanced breast cancer patients. Proc Am Soc Clin Oncol 1997; 16: A659
8. Zaniboni A, Bolognesi A, Arnoldi E et al. Oral idarubicin and cyclophosphamide for metastatic breast cancer in elderly patients. Anticancer Drugs 1998; 9 (4): 295-9.
9. Wallace J, Twelves CJ, Canney P et al. A phase I and pharmacokinetic (PK) study of a new oral schedule for idarubicin (IDA) in advanced breast cancer. Proc Am Soc Clin Oncol 1999; 18: A420.