The novel anticancer drug KRN5500 interacts with, but is hardly transported by, human P-glycoprotein

Japanese Journal of Cancer Research

Volumn 91, Issue 2, 2000, Pages 248-254

  Takara, Kohji ^a   Tanigawara, Yusuke ^b   Komada, Fusao ^a,c   Nishiguchi, Kohshi ^a   Sakaeda, Toshiyuki ^a   Okumura, Katsuhiko ^a  

^a KOBE UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c JOSAI UNIVERSITY   (Japan)

Author keywords

Cellular pharmacokinetic analysis; KRN5500; Multidrug resistance; P Glycoprotein

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 6 [4 DEOXY 4 (2,4 TETRADECADIENOYLGLYCYLAMINO) GLYCERO BETA MANNOHEPTOPYRANOSYLAMINO] 9H PURINE; ANTINEOPLASTIC AGENT; AZIDOPINE; CARBON 14; COMPLEMENTARY DNA; GLYCOPROTEIN P; SPICAMYCIN DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG; VALSPODAR;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASEMENT MEMBRANE; CELL MEMBRANE TRANSPORT; COMPARATIVE STUDY; COMPETITIVE INHIBITION; DRUG ACCUMULATION; DRUG BINDING; DRUG INHIBITION; DRUG TRANSPORT; EPITHELIUM CELL; GENE OVEREXPRESSION; GENETIC TRANSFORMATION; GROWTH INHIBITION; HUMAN; KIDNEY CELL; MONOLAYER CULTURE; MULTIDRUG RESISTANCE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; SWINE;

EID: 0034012855     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb00938.x     Document Type: Article

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