Morphometric grading of breast cancer: Thresholds for tubular differentiation

British Journal of Cancer

Volumn 82, Issue 10, 2000, Pages 1656-1661

  Kronqvist, P ^a   Kuopio, T ^b   Collan, Y ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b Jyväskylä Ctrl Hospital   (Finland)

Author keywords

Breast carcinoma; Grading; Prognosis; Tubular differentiation

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER MORTALITY; CANCER STAGING; CELL DIFFERENTIATION; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MORPHOMETRICS; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; STATISTICAL ANALYSIS;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; AXILLA; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; FEMALE; HUMANS; LYMPH NODES; MENOPAUSE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REPRODUCIBILITY OF RESULTS; RISK; ROC CURVE;

EID: 0034012050     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Altman DG, Lausen B, Sauerbrei W and Schumecher M (1994) Dangers of using 'optimal' cutpoints in the evaluation of prognostic factors. J Natl Cancer Inst 86: 829-835
2. Baak JPA, Van Dop H, Kurver PHJ and Hermans J (1985) The value of morphometry to classic prognosticators in breast cancer. Cancer 56: 374-382
3. Beck JR and Schulz EK (1986) The use of relative operating characteristics (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110: 13-20
4. Berger U, Wilson P, McClelland KA, Davidson J and Coombes RC (1987) Correlation of immunocytochemically demonstrated estrogen receptor distribution and histopathologic features in primary breast cancer. Hum Path 18: 1263-1267
5. Black MM, Opler SR and Speer FD (1955) Survival in breast cancer cases in relation to the structure of the primary tumour and regional lymph nodes. Surg Gynecol Obstet 100: 543-552
6. Black MM, Barclay THC and Hankey BF (1975) Prognosis in breast cancer utilizing histological characteristics of the primary tumour. Cancer 36: 2048-2055
7. Bloom HJG and Richardson WW (1957) Histological grading and prognosis in breast cancer. Br J Cancer 11: 359-377
8. Clayton F (1991) Pathologic correlates of survival in 378 lymph node-negative infiltrating ductal breast carcinomas. Mitotic count is the best single predictor. Cancer 68: 1309-1317
9. Collan Y (1989) General principles of grading lesions in diagnostic histopathology. Pathol Res Pract 185: 539-543
10. Collan Y, Kuopio T and Alanen K (1992) Scope and concepts of quantitative histopathology. Acta Stereol 11: 3-23
11. Cutler SJ and Ederer F (1958) Maximum utilization of the life table method in analyzing survival. J Chron Dis 8: 699-712
12. Dalton LW, Page DL and Dupont WD (1994) Histologic grading of breast carcinoma. A reproducibility study. Cancer 73: 2765-2770
13. Davis BW, Gelber D, Goldhirsh A, Hartmann WH, Locher GW, Reed R, Golouh R, Säve-Söderbergh J, Holloway L and Russel I (1986) Prognostic significance of tumour grade in clinical trials of adjuvant therapy for breast cancer with axillary lymph nodes metastasis. Cancer 58: 2662-2670
14. Dufer J, Liataud-Roger F, Barbarin D and Coninx P (1993) Nucleus image analysis as a possible prognostic tool in grading breast cancer. Biomed Pharmacother 47: 131-135
15. Ellis CW and Elston IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403-410
16. Fisher ER (1986) Prognostic and therapeutic significance of pathological features of breast cancer. NCI Monogr 1: 29-34
17. Fisher ER, Gregorio RM and Fisher B (1975) The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (Protocol No. 4). Cancer 36: 1-85
18. Fisher ER, Redmond C and Fisher B (1980) Histologic grading of breast cancer. Path Annu 15: 239-251
19. Fisher ER, Sass R and Fisher B (1984) Pathologic findings from the national surgical adjuvant project for breast cancer (protocol no 4). Discriminants for tenth year treatment failure. Cancer 53: 712-723
20. Fisher ER, Anderson S, Redmond C and Fisher B (1993) Pathologic findings from the National Surgical Adjuvant Breast Project Protocol B-06. 10 year pathological and clinical prognostic discriminants. Cancer 71: 2507-2514
21. Galen RS and Gambino SR (1975) Beyond normality. In: The Predicted Value and Efficiency of Medical Diagnosis, pp. 49-51, 115-116. John Wiley and Sons: New York
22. Garne JP, Aspegren K, Linell F, Rank F and Ranstam J (1994) Primary diagnostic factors in invasive breast cancer with special reference to ductal carcinoma and histological malignancy grade. Cancer 73: 1438-1448
23. Hanley JA and McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143: 29-36
24. Haybittle JL, Blamey RW, Elston CW, Johnson J, Doyle PJ, Campbell FC, Nicholson RI and Griffiths K (1982) A prognostic index in primary breast cancer. Br J Cancer 45: 361-366
25. Kairisto V and Poola A (1995) Software for illustrative presentation of basic clinical characteristics of laboratory tests - GraphROC for Windows. Scand J Clin Lab Invest 55: 43-60
26. Kronqvist P, Kuopio T and Collan Y (1998a). Breast cancer prognostication: morphometric thresholds for nuclear grading. Br J Cancer 78: 800-805
27. Kronqvist P, Kuopio T and Collan Y (1998b) Morphometric grading in breast cancer: thresholds for mitotic counts. Hum Pathol 29: 1462-1468
28. Kronqvist P, Kuopio T, Pirvu C and Collan Y (1999) The fraction of fields showing neoplastic tubuli: practical estimate of tubular differentiation in breast cancer. Histopathology 35: 401-410
29. Le Doussal V, Tubiana-Hulin M, Friedman S, Hacene K, Spyratos F and Brunet M (1989) Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64: 1914-1921
30. Lipponen PK, Collan Y and Eskelinen MJ (1991) Volume corrected mitotic index (M/V index), mitotic activity index (MAI), and histological grading in breast cancer. Int Surg 76: 245-249
31. Parham DM, Hagen N and Brown RA (1992) Simplified method of grading primary carcinomas of the breast. J Clin Pathol 45: 517-520
32. Parl FF and Dupont WD (1982) A retrospective cohort study of histologic risk factors in breast cancer patients. Cancer 50: 2410-2416
33. Patey DH and Scarff RW (1928) The position of histology in the prognosis of carcinoma of the breast. Lancet 1: 801-804
34. Rank F, Dombernowsky P, Bang-Jespersen NC, Pedersen BV and Keiding N (1987) Histologic malignancy grading of invasive breast carcinoma: A regression analysis of prognostic factors in low-risk carcinomas from a multicenter trial. Cancer 60: 1299-1305
35. Robbins P, Pinder S, De Klerk N, Dawkins H, Harvey J, Sterett G, Ellis I and Elston C (1995) Histological grading of breast carcinomas: A study of interobserver agreement. Hum Pathol 26: 873-879
36. Roberts AN and Hahnel R (1981) Oestrogen receptor assay and morphology of breast cancer. Pathology 13: 317-325
37. Schumacher M, Schmoor C, Sauerbrei W, Schauer, A, Ummenhof L, Gatzmeier W and Rauschecker H (1993) The prognostic effect of histological tumour grade in node-negative breast cancer patients. Breast Cancer Res Treat 25: 235-245
38. Simpson JF and Page DL (1994) Status of breast cancer prognostication based on histopathologic data. Am J Clin Pathol 102(suppl 1): S3-S8
39. Theissig F, Kunze KD, Haroske G and Meyer W (1990) Histological grading of breast cancer. Interobserver reproducibility and prognostic significance. Path Res Pract 186: 732-736
40. Todd JH, Dowle C, Williams MR, Elston CW, Ellis IO, Hinton C, Blamey RW and Haybittle JL (1987) Confirmation of a prognostic index in primary breast cancer. Br J Cancer 56: 489-492
41. Tosi P, Luzi P, Sfora V, Sanpietro R, Bindi M, Tucci E, Barbini P and Baak JP (1986) Correlation between morphometrical parameters and disease-free survival in duetal breast cancer treated only by surgery. App Pathol 4: 33-42
42. Van Der Linden JG, Lindeman J, Baak JPA, Meijer CJLM and Hermans CJ (1989) The multivariate prognostic index and nuclear DNA content are independent prognostic factors in primary breast cancer patients. Cytometry 10: 56-61
43. WHO (1981) Histological typing of breast tumours. In: International Histological Classification of Tumours; 2nd edn. World Health Organization: Geneva.
44. Zweig MH and Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39: 561-577