Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution

Magnetic Resonance in Medicine

Volumn 43, Issue 5, 2000, Pages 633-639

  Karczmar, Gregory S ^a,b   Fan, Xiaobing ^a   Al Hallaq, Hania A ^a   Zamora, Marta ^a   River, Jonathan N ^a   Rinker Schaeffer, Carrie ^a   Zaucha, Mithra ^a   Tarlo, Kirk ^c   Kellar, Kenneth ^c  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^c Nycomed Amersham Imaging   (United States)

Author keywords

Cancer; High resolution spectroscopic imaging; Magnetic resonance imaging; Tumor blood vessels; Tumor microenvironments

Indexed keywords

BLOOD VESSELS; IMAGE RESOLUTION; MAGNETIC RESONANCE IMAGING; MOLECULES; SUPERPARAMAGNETISM; TUMORS;

ACCURATE MEASUREMENT; CANCER; MICROVESSEL DENSITY; SPATIAL RESOLUTION; SPECTROSCOPIC IMAGING; STRUCTURE AND DYNAMICS; SUPERPARAMAGNETICS; TUMOR MICROENVIRONMENTS;

IMAGE ENHANCEMENT;

CONTRAST MEDIUM; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFACT; BLOOD VESSEL; CONTRAST ENHANCEMENT; DIAGNOSTIC ACCURACY; MALE; MICROVASCULATURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0034011601     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(200005)43:5<633::AID-MRM3>3.0.CO;2-R     Document Type: Article

References (25)

1. Dixon WT. Simple proton spectroscopic imaging. Radiology 1984;153: 189-194.
2. Glover GH. Multipoint Dixon technique for water and fat proton and susceptibility imaging. J Magn Reson Imaging 1991;1:521-530.
3. Glover GH, Schneider E. Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction. Magn Reson Med 1991;18:371-383.
4. Gold GE, Pauly JM, Macovski A, Herfkens RJ. MR spectroscopic imaging of collagen: tendons and knee menisci. Magn Reson Med 1995;34: 647-654.
5. Al-Hallaq HA, Karczmar G. High resolution 1H spectroscopic imaging of the water and fat resonances in human breast. Int Soc Magn Reson Med 2; 1997.
6. Al-Hallaq HA, River JN, Zamora M, Oikawa H, Karczmar GS. Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation. Int J Radiat Oncol Biol Phys 1998;41:151-159.
7. Oikawa H, Al-Hallaq HA, Lewis MZ, River JN, Kovar DA, Karczmar GS. Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia. Magn Reson Med 1997;38: 27-32.
8. Kuperman V, River JN, Karczmar GS. High resolution spectroscopic images of tumors. Int Soc Magn Res Med; 1995.
9. Kovar DA, Al-Hallaq HA, Zamora MA, River JN, Karczmar GS. Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images. Acad Radiol 1998;5:269-275.
10. Hilaire L, Wehrli FW, Song HK, Hopkins JA. High-speed spectroscopic imaging at 4T for R2* measurement of individual spectral components. Int Soc Magn Reson Med; 1999.
11. Sarkar S, Heberlein K, Metzger GJ, Zhang X, Hu X. Applications of high-resolution echoplanar spectroscopic imaging for structural imaging. J Magn Reson Imaging 1999;10:1-7.
12. Maudsley AA, Hilal SK, Perman WH, Simon HE. Spatially resolved high resolution spectroscopy by "four-dimensional" NMR. J Magn Reson 1983;51:147-152.
13. Brown TR, Kincaid BM, Ugurbil K. NMR chemical shift imaging in three dimensions. Proc Natl Acad Sci USA 1982;79:3523-3526.
14. Sarkar S, Heberlein K, Metzger GJ, Zhang X, Hu X. Applications of high-resolution echoplanar spectroscopic imaging for structural imaging. J Magn Reson Imaging 1999;10:1-7.
15. Posse S, Wiese S, Gembris D, Mathiak K, Kessler C, Grosse-Ruyken ML, Elghahwagi B, Richards T, Dager SR, Kiselev VG. Enhancement of BOLD-contrast sensitivity by single-shot multi-echo functional MR imaging. Magn Reson Med 1999;42:87-97.
16. Koenig SH, Kellar KE. Theory of 1/T1 and 1/T2 NMRD profiles of solutions of magnetic nanoparticles. Magn Reson Med 1995;34:227-233.
17. Karczmar GS, River JN, Goldman Z, Li J, Weisenberg E, Lewis MZ, Liu K. Magnetic resonance imaging of rodent tumors using radiofrequency gradient echoes. Magn Reson Imaging 1994;12:881-893.
18. Villringer A, Rosen BR, Bolliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ. Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med 1988;6:164-174.
19. Brasch RC, Moseley ME, Dupon J, Wang SC, Aicher KP, Wikstrom M, Schmiedl U, Wolfe CL, Ogan MD, Grood W. Macromolecular magnetic resonance imaging contrast media. Accumulated experience. Invest Radiol 1990;25(Suppl. 1):S51-52.
20. Dvorak HF, Nagy JA, Berse B, Brown LF, Yeo KT, Yeo TK, Dvorak AM, van de Water L, Sioussat TM, Senger DR. Vascular permeability factor, fibrin, and the pathogenesis of tumor stroma formation. Ann NY Acad Sci 1992;667:101-111.
21. Neeman M. MR evaluation of angiogenesis in oncology. Int Soc Magn Reson Mod; 1999.
22. Chu SC, Xu Y, Balschi JA, Springer CS Jr. Bulk magnetic susceptibility shifts in NMR studies of compartmentalized samples: use of paramagnetic reagents. Magn Reson Med 1990;13:239-262.
23. Naritomi H, Kanashiro M, Sasaki M, Kuribayashi Y, Sawada T. In vivo measurements of intra- and extracellular Na+ and water in the brain and muscle by nuclear magnetic resonance spectroscopy with shift reagent. Biophys J 1987;52:611-616.
24. Fan X, River JN, Zamora M, Rinker-Schaeffer C, Karczmar GS. Calculation of pure absorption images from spectroscopic data increases image contrast and resolution. Int Soc Magn Reson Med 1999;1341.
25. Mansfield P. Spatial mapping of the chemical shift in NMR. Magn Reson Med 1984;1:370-380.