Role of melanotransferrin (p97) in non-transferrin iron uptake by HeLa and K562 cells

Folia Biologica

Volumn 46, Issue 2, 2000, Pages 77-81

  Kriegerbeckova K ^a   Kovar J ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

HeLa cells; K562 cells; Melanotransferrin; Non transferrin iron uptake; p97

Indexed keywords

FERRIC CITRATE; IRON; IRON BINDING PROTEIN; TRANSFERRIN;

ARTICLE; CELL STRAIN K 562; HELA CELL; HUMAN; HUMAN CELL; IRON TRANSPORT;

EID: 0034010481     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Atkinson, P. G., Blackwell, J. M., Barton, C. H. (1997) Nramp 1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages. Biochem. J. 325, 779-786.
2. Baker, E. N., Baker, H. M., Smith, C. A., Stebbins, M. R., Kahn, M., Hellström, K. E., Hellström, I. (1992) Human melanotransferrin (p97) has only one functional iron-bindina site. FEBS Lett. 298, 215-218.
3. Baker, E., Baker, S. M., Morgan, E. H. (1998) Characterization of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture. Biochim. Biophys. Acta 1380, 21-30.
4. Basset, P., Quesneau, Y., Zwiller, J. (1986) Iron-induced L1210 cell growth: evidence of a transferrin-independent iron transport. Cancer Res. 46, 1644-1647.
5. Brissot, P., Wright, T. L., Ma, W.-L., Weisiger, R. A. (1985) Efficient clearance of non-transferrin-bound iron by rat liver. Implications for hepatic iron loading in iron overload states. J. Clin. Invest. 76, 1463-1470.
6. Brown, J. P., Woodbury, R. G., Hart, C. E., Hellström, I., Hellström, K. E. (1981a) Quantitative analysis of melanoma-associated antigen p97 in normal and neoplaslic tissues. Proc. Natl. Acad. Sci. USA 78, 539-543.
7. Brown, J. P., Nishiyama, K., Hellström, I., Hellström, K. E. (1981b) Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies. J. Immunol. 127, 539-546.
8. Brown, J. P., Hewick, R. M., Hellström, I., Hellström, K. E., Doolittle, R. F., Dreyer, W. J. (1982) Human melanoma-associated antigen p97 is structurally and functionally related to transferrin. Nature 296, 171-173.
9. Brunner-Döpper, L., Kriegerbecková, K., Kovář, K., Goldenberg, H. (1998) Pitfalls in assessing specificity and affinity of non-transferrin-bound iron uptake. Anal. Biochem. 261, 128-130.
10. Conrad, M. E., Umbreit, J. N., Peterson, R. D. A., Moore, E. G., Harper, K. P. (1993) Function of integrin in duodenal mucosal uptake of iron. Blood 81, 517-521.
11. Conrad, M. E., Umbreit, J. N. (1994) Alternate iron transport pathway. Mobilferrin and integrin in K562 cells. J. Biol. Chem. 269, 7169-7173.
12. Dautry-Varsat, A., Ciechanover, A., Lodish, H. F. (1983) pH and the recycling of transferrin during receptor-mediated endocytosis. Proc. Natl. Acad. Sci. USA 80, 2258-2262.
13. Fleming, D. J., Trenor III, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., Andrews, N. C. (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16, 383-386.
14. Food, M. R., Rothenberger, S., Gabathuler, R., Haidl, I. D., Reid, G., Jefferies, W. A. (1994) Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein. J. Biol. Chem. 269, 3034-3040.
15. Goldenberg, H., Scheiber, B. (1995) Biochemical aspects of iron metabolism, transport and regulation. Wien. Klin. Wochenschr. 107, 669-676.
16. Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., Hediger, M. A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482-488.
17. Gutierrez, J. A., Yu, J., Rivera, S., Wessling-Resnick, M. (1997) Functional expression cloning and characterization of SFT, a stimulator of Fe transport. J. Cell. Biol. 139, 895-905.
18. 59Fe uptake in phytohemagglutinin-stimulated human peripheral lymphocytes. Exp. Hematol. 20, 436-441.
19. Inman, R. S., Wessling-Resnick, M. (1993) Characterization of transferrin-independent iron transport in K562 cells. Unique properties provide evidence for multiple pathways of iron uptake. J. Biol. Chem. 268, 8521-8528.
20. Kaplan, J., Jordan, I., Sturrock, A. (1991) Regulation of the transferrin-independent iron transport system in cultured cells. J. Biol. Chem. 266, 2997-3004.
21. Kennard, M. L., Food, M. R., Jefferies, W. A., Piret, J. M. (1993) Controlled release process to recover heterologous glycosylphosphatidylinositol membrane anchored proteins from CHO cells. Biotechnol. Bioeng. 42, 480-486.
22. Kennard, M. L., Richardson, D. R., Gabathuler, R., Ponka, P., Jefferies, W. A. (1995) A novel iron uptake mechanism mediated by GPI-anchored human p97. EMBO J. 14, 4178-4186.
23. Klausner, R. D., Ashwell, G., van Renswoude, J., Harford, J. B., Bridges, K. R. (1983) Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc. Natl. Acad. Sci. USA 80, 2263-2266.
24. Kovář, J., Franěk, F. (1987) Iron compounds at high concentrations enable hybridoma growth in a protein-free medium. Biotechnol. Lett. 9, 259-264.
25. Kovář, J., Kühn, L. C., Richardson, V., Seiser, C., Kriegerbecková, K., Musílková, J. (1997) The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein (IRP). In Vitro Cell. Dev. Biol. 33, 633-639.
26. Kriegerbecková, K., Döpper, L., Scheiber, B., Kovář, J., Goldenberg, H. (1995) Non-transferrin iron uptake by HeLa cells cultured in serum-free media with different iron sources. Eur. J. Clin. Chem. Clin. Biochem. 33, 791-797.
27. Morgan, E. H. (1988) Membrane transport of non-tranferrin-bound iron by reticulocytes. Biochim. Biophys. Acta 943, 428-439.
28. Musílková, J., Kriegerbecková, K., Krůšek, J., Kovář, J. (1998) Specific binding to plasma membrane is the first step in the uptake of non-transferrin iron by cultured cells. Biochim. Biophys. Acta 1369, 103-108.
29. Núñez, M. T., Pinto, I., Glass, J. (1989) Assay and characteristics of the iron binding moiety of reticulocyte endocytic vesicles. J. Membrane Biol. 107, 129-135.
30. 2+ transport. J. Biol. Chem. 267, 11490-11494.
31. Olakanmi, O., Stokes, J. B., Pathan, S., Britigan, B. E. (1997) Polyvalent cationic metals induce the rate of transferrin-independent iron acquisition by HL-60 cells. J. Biol. Chem. 272, 2599-2606.
32. 3+ transport by iron-loaded cardiac myocytes. Toxicology 117, 141-151.
33. Richardson, D. R., Baker, E. (1990) The uptake of iron and transferrin by the human malignant melanoma cells. Biochim. Biophys. Acta 1053, 1-12.
34. Richardson, D., Baker, E. (1991) The uptake of inorganic iron complexes by human melanoma cells. Biochim. Biophys. Acta 1093, 20-28.
35. Seligman, P. A., Kovář, J., Schleicher, R. B., Gelfand, E. W. (1991) Transferrin-independent iron uptake supports B lymphocyte growth. Blood 78, 1526-31.
36. Sturrock, A., Alexander, J., Lamb, J., Craven, C. M., Kaplan, J. (1990) Characterization of a transferrin-independent uptake system for iron in HeLa cells. J. Biol. Chem. 265, 3139-3145.
37. Teichmann, R., Stremmel, W. (1990) Iron uptake by human upper small intestine microvillous membrane vesicles. J. Clin. Invest. 86, 2145-2153.
38. Umbreit, J. N., Conrad, M. E., Berry, M. A., Moore, E. G., Latour, L. F., Tolliver, B. A., Elkhalifa, M. Y. (1997) The alternate iron transport pathway: mobilferrin and integrin in reticulocytes. Br. J. Haematol. 96, 521-529.
39. Wright, T. L., Fitz, J. G., Weisiger, R. A. (1988) Non-transferrin-bound iron uptake by rat liver. Role of membrane potential difference. J. Biol. Chem. 263, 1842-1847.