Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 3, 2000, Pages 870-876

  Llansola, Marta ^a   Monfort, Pilar ^a   Felipo, Vicente ^a,b  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b Laboratorio de Neurobiologia de Prince Felipe Research Centre   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1 O OCTADECYL 2 O METHYL GLYCERO 3 PHOPHORYLCHOLINE; CARBACHOL; GLUTAMIC ACID; N ACETYL S NITROSOPENICILLAMINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPASE C INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CEREBELLUM; DEGENERATIVE DISEASE; DRUG EFFECT; ENZYME INHIBITION; HYDROLYSIS; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT;

ANIMALS; CARBACHOL; CELLS, CULTURED; CEREBELLUM; ESTRENES; GLUTAMIC ACID; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C; PHOSPHOLIPID ETHERS; PYRROLIDINONES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0034009236     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. 2+ ion concentrations. Biochem J 327:545-552.
2. Berstein G, Blank JL, Smrcka AV, Higashijima T, Sternweis PC, Exton JH and Ross EM (1992) Reconstitution of agonist-stimulated phosphatidylinositol 4,5-biphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-β1. J Biol Chem 267:8081-8088.
3. Bleasdale JE, Bundy GL, Bunting S, Fitzpatrick FA, Huff RM, Sun FF and Pike JE (1989) Inhibition of phospholipase C dependent processes by U-73122. Adv Prostaglandin Thromboxane Leukot Res 19:590-593.
4. Choi DW (1987) Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379.
5. Choi DW (1992) Excitotoxic cell death. J Neurobiol 23:1261-1276.
6. Drapier JC (1997) Interplay between NO and [Fe-S] clusters: Relevance to biological systems. Methods 11:319-329.
7. Felipo V, Miñana MD, Cabedo H and Grisolia S (1994) L-carnitine increases the affinity of glutamate for quisqualate receptors and prevents glutamate neurotoxicity. Neurochem Res 19:373-377.
8. Felipo V, Minana MD and Grisolia S (1993) Inhibitors of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain Res 604:192-196.
9. Fisher SK, Figueiredo JC and Bartus RT (1984) Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine. J Neurochem 43:1171-1179.
10. Fragoso G and Lopez-Colome AM (1999) Excitatory amino acid-induced inositol phosphate formation in cultured retinal pigment epithelium. Vis Neurosci 16:263-269.
11. Frandsen A and Schousboe A (1993) Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. J Neurochem 60:1202-1211.
12. Hodson EA, Ashley CC, Hughes AD and Lymn JS (1998) Regulation of phospholipase C delta 1 activity by GTP-binding proteins: Rho-A as an inhibitory modulator. Biochem Soc Trans 26:8128.
13. Hokin LE, Dixon JF and Los GV (1996) A novel action of lithium: Stimulation of glutamate release and inositol 1,4,5 triphosphate accumulation via activation of the N-methyl D-aspartate receptor in monkey and mouse cerebral cortex slices. Adv Enzyme Regul 36:229-244.
14. Homma Y and Emori Y (1995) A dual functional signal mediator showing RhoGAP and phospholipase C-δ stimulating activities. EMBO J 14:286-291.
15. Hu GF (1998) Neomycin inhibits angiogenin induced angiogenesis. Proc Natl Acad Sci USA 95:9791-9795.
16. Illenberger D, Schwald F, Pimmer D, Binder W, Maier G, Dietrich A and Gierschick P (1998) Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1. EMBO J 17:6241-6249.
17. Katsuki S, Arnold W, Mittal C and Murad F (1977) Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res 3:23-35.
18. Koh JY, Palmer E and Cotman CW (1991) Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures. Proc Natl Acad Sci USA 88:9431-9435.
19. Marcaida G, Miñana MD, Grisolía S and Felipo V (1995) Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum. Brain Res 695:146-150
20. Matecki A and Pawelczyk T (1997) Regulation of phospholipase C delta 1 by sphingosine. Biochim Biophys Acta 325:287-296.
21. Miñana MD, Montoliu C, Llansola M, Grisolía S and Felipo V (1998) Nicotine prevents glutamate-induced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons. Neuropharmacology 3:847-857.
22. Montoliu C, Llansola M, Cucarella C, Grisolía S and Felipo V (1997) Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons. J Pharmacol Exp Ther 281:643-647.
23. Nicoletti F, Wroblewski JT, Novelli A, Alho H, Guidotti A and Costa E (1986) The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. J Neurosci 6:1905-1911.
24. Pawelczyk T (1999) Isozymes delta of phosphoinositide-specific phospholipase C. Acta Biochim Pol 46:91-98.
25. Powis G, Seewald MJ, Gratas C, Melder D, Riebow J and Modest EJ (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res 52:2835-2840.
26. 2+/calmodulin-binding peptides block phototransduction in Limulus ventral photoreceptors: Evidence for direct inhibition of phospholipase C. Proc Natl Acad Sci USA 94:14095-14099.
27. Schmidt M, Rumenapp U, Keller J, Lohmann B and Jakobs KH (1997) Regulation of phospholipase C and D activities by small molecular weight G proteins and muscarinic receptors. Life Sci 60:1093-1100.
28. Shibatohge M, Kariya K, Liao Y, Hu CD, Watari Y, Goshima M, Shima F and Kataoka T (1998) Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras. J Biol Chem 273:6218-6222.
29. Shimohama S, Akaike A, Tamura Y, Matsushima H, Kume T, Fujimoto S, Takenawa T and Kimura J (1995) Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons. J Neurosci Res 41:418-426.
30. Siliprandi R, Lipartiti M, Fadda E, Sautter J and Manev H (1992) Activation of the metabotropic receptor protects retina against N-methyl-D-aspartate toxicity. Eur J Pharmacol 219:173-174.
31. Smith RJ, Sam LM, Justen JM, Bundy GL, Bala GA and Bleasdale JE (1990) Receptor-coupled signal transduction in human polymorphonuclear neutrophils effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther 253:288-297.
32. Smith SS and Li J (1993) Novel action of nitric oxide as mediator of N-methyl-D-aspartate-induced phosphatidylinositol hydrolysis in neonatal rat cerebellum. Mol Pharmacol 43:1-5.
33. Wright DT, Fischer BM, Li C, Rochelle LG, Akley NJ and Adler KB (1996) Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. Am J Physiol 271 (5 Pt 1):L854-L861.
34. Yun HY, Gonzalez-Zulueta M, Dawson VL and Dawson TM (1998) Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proc Natl Acad Sci USA 95:5773-5778.