Plasma from ESRD patients inhibits nitric oxide synthase activity in cultured human and bovine endothelial cells

Acta Physiologica Scandinavica

Volumn 168, Issue 1, 2000, Pages 175-179

  Xiao, ^a   Schmidt, ^a   Baylis, ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Asymmetric dimethylarginine (ADMA); Bovine aortic endothelial cells; Dermal microvascular endothelial cells; Endogenous nitric oxide synthase inhibitors; Glomerular capillary endothelial cell; Kidney failure; Nitrate and nitrite; NO(x) plasma

Indexed keywords

DEXAMETHASONE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; CATTLE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HEMODIALYSIS; HUMAN; HUMAN CELL; HYPERTENSION; KIDNEY FAILURE; NONHUMAN; PERITONEAL DIALYSIS; PRIORITY JOURNAL;

ANIMALS; AORTA, THORACIC; BLOOD PHYSIOLOGY; CAPILLARIES; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY GLOMERULUS; MICROCIRCULATION; NITRIC OXIDE SYNTHASE; PERITONEAL DIALYSIS; REFERENCE VALUES; RENAL DIALYSIS; SKIN;

EID: 0034008250     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201x.2000.00640.x     Document Type: Article

References (27)

1. Amore, A., Cirina, P., Mitola, S. et al. 1997. Acetate intolerance is mediated by enhance synthesis of nitric oxide by endothelial cells. J Am Soc Nephrol 8, 1431-1436.
2. G-dimethyl-L arginine, a potential endogenous nitric oxide inhibitor in dialysis patients. J Am Soc Nephrol 8, 1437-1442.
3. Arese, M., Strasly, M., Ruva, C. et al. 1995. Regulation of nitric oxide synthesis in uremia. Nephrol Dial Transplant 10, 1386-1397.
4. Baylis, C. & Vallance, P. 1996. Nitric oxide and blood pressure: effects of NO deficiency. Curr Op Nephrol Hypert 5, 80-88.
5. Bredt, D.S. & Synder, S.H. 1994. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63, 175-196.
6. Davda, R.K., Chandler, L.J., Crews, F.T. & Guzman, N.J. 1993. Ethanol enhances endothelial nitric oxide synthase response to agonists. Hypertension 21, 939-943.
7. Funai, E.F., Davidson, A., Seligman, S.P. & Finlay, T.H. 1997. S-Nitrosohemoglobin in the fetal circulation may represent a cycle for blood pressure regulation. Biochem Biophys Res Commun 293, 875-877.
8. Hand, M.F., Haynes, W.G. & Webb, D.J. 1998. Hemodialysis and L-arginine, but not D-arginine, corrects renal failure-associated endothelial dysfunction. Kidney Int 53, 1068-1077.
9. Huang, P.L., Huang, Z., Mashimo, H. et al. 1995. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377, 239-242.
10. Kielstein, J.T., Boger, R.H., Bode-Boger, S.M. et al. 1999. Asymmetric dimethylarginine plasma concentrations differ in patients with ESRD: relationship to treatment method and atherosclerotic disease. J Am Soc Nephrol 10, 594-600.
11. Liang, Y., Vandivier, R.W., Suffredini, A.F. & Danner, R.L. 1994. Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity. J Immunol 153, 1825-1834.
12. Marescau, B.G., Nagels, G., Possemiers, I. et al. 1997. Guanidino compounds in serum and urine of nondialysed patents with chronic renal insufficiency. Metabolism 46, 1024-1031.
13. Moncada, S., Palmer, R.M. & Higgs, E.A. 1995. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43, 109-142.
14. Peterson, G.L. 1979. Review of the folin phenol protein quantitation method of Lowry, Rosebrough, Farr, and Randall. Anal Biochem 100, 201-220.
15. Reyes, A.A., Karl, I.E., Kissane, J. & Klahr, S. 1993. L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J Am Soc Nephrol 4, 1039-1045.
16. Rostand, S.G., Brunzell, J.D., Cannon, R.O. & Victor, R.G. 1991. Cardiovascular complications in renal failure. J Am Soc Nephrol 2, 1053-1062.
17. Saijonmaa, O., Metsarinne, K. & Fyhrquist, F. 1997. Carvedilol and its metabolites suppress endothelin-1 production in human endothelial cell culture. Blood Press 6, 24-28.
18. Schmidt, R.J., Yokota, S., Tracy, T.S., Sorkin, M.I. & Baylis, C. 1999a. Nitric oxide production is low in end stage renal disease patients on peritoneal dialysis. Am J Physiol 276, F794-F797.
19. Schmidt, R., Domico, J., Samsel, L. et al. 1999b. Indices of activity of the nitric oxide system in patients on hemodialysis. Am J Kidney Dis 34, 228-234.
20. Simmons, W.W., Ungureanu-Longrosis, D., Smith, G.K., Smith, T.W. & Kelly, R.A. 1996. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. J Biol Chem 271, 23928-23937.
21. Soma, M., Nakayama, T. & Kanmatsuse, K. 1999. NOS gene polymorphism and its influence on cardiovascular disease. Curr Op Nephrol Hypert 8, 83-87.
22. Suto, T., Losonczy, G., Qiu, C. et al. 1995. Acute changes in urinary excretion of nitrite + nitrate do not necessarily predict renal vascular NO production. Kidney Int 48, 1272-1277.
23. Vallance, P., Leone, A., Calver, A., Collier, J. & Moncada, S. 1992. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339, 572-575.
24. + when the Griess reaction is used to assay for nitrite. Anal Biochem 224, 502-508.
25. Wiemer, G., Fink, K., Linz, W., Hropot, M., Scholkens, B.E. & Wohlfart, P. 1994. Furosemide enhances the release of endothelial kinins, nitric oxide and prostacylin. J Pharmacol Exp Ther 271, 161-165.
26. Xiao, S., Schmidt, R., Howton, M., Engels, K. & Baylis. C. 1999. Chronic renal disease plasma on nitric oxide synthase activity in cultured endothelial cells (Abstract). FASEB 13, 125.37.
27. Zhang, X., Recchia, F.A., Bernstein, R., Xu, X., Nasjletti, A. & Hintze, T.H. 1999. Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure. J Pharmacol Exp Ther 288 (2), 742-751.