Involvement of genotoxic effects in the initiation of estrogen-induced cellular transformation: Studies using syrian hamster embryo cells treated with 17β-estradiol and eight of its metabolites

International Journal of Cancer

Volumn 86, Issue 1, 2000, Pages 8-14

  Tsutsui, Takeki ^a   Tamura, Yukiko ^a   Yagi, Eiichi ^a   Barrett, J Carl ^b  

^a NIPPON DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA HYDROXYESTRONE; 2 HYDROXYESTRADIOL; 2 HYDROXYESTRONE; 2 METHOXYESTRONE; 4 HYDROXYESTRADIOL; ESTRADIOL; ESTRADIOL DERIVATIVE; ESTRIOL; ESTRONE; ESTRONE DERIVATIVE;

ANEUPLOIDY; ANIMAL MODEL; ARTICLE; CELL TRANSFORMATION; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; EMBRYO; ESTROGEN ACTIVITY; GENE MUTATION; GENOTOXICITY; HORMONAL CARCINOGENESIS; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER;

ANEUPLOIDY; ANIMALS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CRICETINAE; ESTRADIOL; FETUS; HYDROXYESTRONES; MESOCRICETUS; STEM CELLS;

EID: 0034007347     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000401)86:1<8::AID-IJC2>3.0.CO;2-V     Document Type: Article

References (20)

1. ABE, S. and SASAKI, M., Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals. J. nat. Cancer Inst., 58, 1635-1641 (1977).
2. AIZU-YOKOTA, E., SUSAKI, A. and SATO. Y., Natural estrogens induce modulation of microtubules in Chinese hamster V79 cells in culture. Cancer Res., 55,1863-1868 (1995).
3. ARTS, C.J., WILMER, J.W., DEBIE, A.T. and VAN DEN BERG, H., In vitro synthesis of 16α-hydroxyestrone by female rat liver microsomes: its possible role in the etiology of breast cancer. J. Steroid Biochem., 36, 527-531 (1990).
4. BARRETT, J.C., BIAS, N.E. and TS'O, P.O.P., A mammalian cellular system for the concomitant study of neoplastic transformation and somatic mutation. Mutation Res., 50, 121-136 (1978).
5. CAVALIERI, E.L. and 12 OTHERS, Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc. nat. Acad. Sci. (Wash.), 94, 10937-10947 (1997).
6. DREVON, C., PICCOLI, C. and MONTESANO, R., Mutagenicity assays of estrogenic hormones in mammalian cells. Mutation Res., 89, 83-90 (1981).
7. DUNN, J.F.,Transport of estrogens in human plasma. In: G.R. Merriam and M.B. Lipsett (eds.), Catechol estrogens, pp. 167-176, Raven, New York (1983).
8. FOTSIS, T., ZHANG, Y., PEPPER, M.S., ADLERCREUTZ, H., MONTESANO, R., NAWROTH, P.P. and SCHWELGERER, L., The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumor growth. Nature (Lond.), 368, 237-239 (1994).
9. HILL, A. and WOLFF, S., Sister chromatid exchanges and cell division delays induced by diethylstilbestrol, estradiol, and estriol in human lymphocytes. Cancer Res., 43, 4114-4118 (1983).
10. IARC, Sex hormones (II). IARC monogr., 21, 139-362 (1979).
11. KOCHHAR, T.S., Inducibility of chromosome aberrations by steroid hormones in cultured Chinese hamster ovary cells. Toxicol. Lett., 29, 201-206 (1985).
12. LI, J.J., LI, S.A., OBERLEY, T.D. and PARSONS, J.A., Carcinogenic activities of various steroidal and nonsteroidal estrogens in the hamster kidney: relation to hormonal activity and cell proliferation. Cancer Res., 55, 4347-4351 (1995).
13. OSHIRO, Y., BALWIERZ, P.S. and PIPER, C.E., Absence of a genotoxic response from steroids in the rat primary hepatocyte unscheduled DNA synthesis assay, Environ. Mutagenesis, 8, 461-465 (1986).
14. ROY, D. and LIEHR, J.G., Estrogen, DNA damage and mutations. Mutation Res., 424, 107-115 (1999).
15. TELANG, N.T., SUTO, A., WONG, G.Y., OSBORNE, M.P. and BRADLOW, H.L., Induction by estrogen metabolite 16α-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J. nat. Cancer Inst., 84, 634-638 (1992).
16. TSUTSUI, T. and BARRETT, J.C., Neoplastic transformation of cultured mammalian cells by estrogens and estrogenlike chemicals. Environ. Health Perspect., 105, 619-624 (1997).
17. YAGER, J.D. JR. and YAGER, R., Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats. Cancer Res., 40, 3680-3685 (1980).
18. YU, S.C. and FISHMAN, J., Interaction of histones with estrogens. Covalent adduct formation with 16α-hydroxyestrone. Biochemistry, 24, 8017-8021 (1985).
19. ZHU, B.T. and CONNEY, A.H., Functional role of estrogen metabolism in target cells: review and perspective. Carcinogenesis, 19, 1-27 (1998a).
20. ZHU, B.T. and CONNEY, A.H., Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Res., 58, 2269-2277 (1998b).