-
1
-
-
0032435382
-
PPAR-alpha mediated responses and their importance in carcinogenesis
-
James, N., Gill, J., Brindle, R., Woodyatt, N., Macdonald, N., Rolfe, M., Holden, P., Tugwood, J. and Roberts, R. (1998) PPAR-alpha mediated responses and their importance in carcinogenesis. Toxicol. Lett., 102-103, 91-96.
-
(1998)
Toxicol. Lett.
, vol.102-103
, pp. 91-96
-
-
James, N.1
Gill, J.2
Brindle, R.3
Woodyatt, N.4
Macdonald, N.5
Rolfe, M.6
Holden, P.7
Tugwood, J.8
Roberts, R.9
-
2
-
-
0031695507
-
Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens
-
Christensen, J.G., Gonzales, A.J., Cattley, R.C. and Goldsworthy, T.L. (1998) Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens. Cell Growth Differ., 9, 815-825.
-
(1998)
Cell Growth Differ.
, vol.9
, pp. 815-825
-
-
Christensen, J.G.1
Gonzales, A.J.2
Cattley, R.C.3
Goldsworthy, T.L.4
-
3
-
-
0033051348
-
The perturbation of apoptosis and mitosis by drugs and xenobiotics
-
Hasmall, S.C. and Roberts, R.A. (1999) The perturbation of apoptosis and mitosis by drugs and xenobiotics. Pharmacol. Ther., 82, 63-70.
-
(1999)
Pharmacol. Ther.
, vol.82
, pp. 63-70
-
-
Hasmall, S.C.1
Roberts, R.A.2
-
4
-
-
0032842585
-
Cytokines in non-genotoxic hepatocarcinogenesis
-
Roberts, R.A. and Kimber, I. (1999) Cytokines in non-genotoxic hepatocarcinogenesis Carcinogenesis, 20, 1397-1401.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1397-1401
-
-
Roberts, R.A.1
Kimber, I.2
-
5
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
6
-
-
0031418657
-
Role of PPAR-alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
-
Peters, J., Cattley, R. and Gonzalez, F. (1997) Role of PPAR-alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis, 18, 2029-2033.
-
(1997)
Carcinogenesis
, vol.18
, pp. 2029-2033
-
-
Peters, J.1
Cattley, R.2
Gonzalez, F.3
-
7
-
-
0031428482
-
Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: A mediator of the hepatocarcinogenicity of peroxisome proliferators?
-
Rolfe, M., James, N. and Roberts, R. (1997) Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis, 18, 2277-2280.
-
(1997)
Carcinogenesis
, vol.18
, pp. 2277-2280
-
-
Rolfe, M.1
James, N.2
Roberts, R.3
-
8
-
-
0031417341
-
Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643
-
Bojes, H., Germolec, D., Simeonova, P., Bruccoleri, A., Schoonhoven, R., Luster, M. and Thurman, R. (1997) Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643. Carcinogenesis, 18, 669-674.
-
(1997)
Carcinogenesis
, vol.18
, pp. 669-674
-
-
Bojes, H.1
Germolec, D.2
Simeonova, P.3
Bruccoleri, A.4
Schoonhoven, R.5
Luster, M.6
Thurman, R.7
-
9
-
-
0031682110
-
Mechanisms of hepatic toxicity. I. TNF-induced liver injury
-
Bradham, C.A., Plümpe, J., Manns, M.P., Brenner, D.A. and Trautwein, C. (1998) Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am. J. Phys., 275, G387-G392.
-
(1998)
Am. J. Phys.
, vol.275
-
-
Bradham, C.A.1
Plümpe, J.2
Manns, M.P.3
Brenner, D.A.4
Trautwein, C.5
-
10
-
-
0029114596
-
Two tumour necrosis factor receptors: Structure and function
-
Vandenabeele, P., Declercq, W., Beyaert, R. and Fiers, W. (1995) Two tumour necrosis factor receptors: structure and function. Trends Cell Biol., 5, 392-399.
-
(1995)
Trends Cell Biol.
, vol.5
, pp. 392-399
-
-
Vandenabeele, P.1
Declercq, W.2
Beyaert, R.3
Fiers, W.4
-
11
-
-
0030955880
-
Nonparenchymal cells from regenerating rat liver generate interleukin-1 alpha and -1 beta: A mechanism of negative regulation of hepatocyte proliferation
-
Boulton, R., Woodman, A., Calnan, D., Seiden, C., Tam, F. and Hodgson, H. (1997) Nonparenchymal cells from regenerating rat liver generate interleukin-1 alpha and -1 beta: a mechanism of negative regulation of hepatocyte proliferation. Hepatology, 26, 49-58.
-
(1997)
Hepatology
, vol.26
, pp. 49-58
-
-
Boulton, R.1
Woodman, A.2
Calnan, D.3
Seiden, C.4
Tam, F.5
Hodgson, H.6
-
12
-
-
0032526358
-
IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections
-
Gregory, S., Wing, E., Danowski, K., van Rooijen, N., Dyer, K. and Tweardy, D. (1998) IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J. Immunol., 160, 6056-6061.
-
(1998)
J. Immunol.
, vol.160
, pp. 6056-6061
-
-
Gregory, S.1
Wing, E.2
Danowski, K.3
Van Rooijen, N.4
Dyer, K.5
Tweardy, D.6
-
13
-
-
0031419250
-
Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators
-
Rose, M., Germolec, D., Schoonhoven, R. and Thurman, R. (1997) Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis, 18, 1453-1456.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1453-1456
-
-
Rose, M.1
Germolec, D.2
Schoonhoven, R.3
Thurman, R.4
-
14
-
-
0032896542
-
Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators
-
Rose, M.L., Rivera, C.A., Bradford, B.U., Graves, L.M., Cattley, R.C., Schoonhoven, R., Swenberg, J.A. and Thurman, R.G. (1999) Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators. Carcinogenesis, 20, 27-33.
-
(1999)
Carcinogenesis
, vol.20
, pp. 27-33
-
-
Rose, M.L.1
Rivera, C.A.2
Bradford, B.U.3
Graves, L.M.4
Cattley, R.C.5
Schoonhoven, R.6
Swenberg, J.A.7
Thurman, R.G.8
-
15
-
-
0032935664
-
Mitogen-activated protein kinases:Specific messages from ubiquitous messengers
-
Schaeffer, M.J. (1999) Mitogen-activated protein kinases:specific messages from ubiquitous messengers. Mol. Cell. Biol., 19, 2435-2444.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2435-2444
-
-
Schaeffer, M.J.1
-
16
-
-
0030898417
-
Mitogen-activated protein kinase pathways
-
Robinson, M.J. and Cobb, M.H. (1997) Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol., 9, 180-186.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 180-186
-
-
Robinson, M.J.1
Cobb, M.H.2
-
17
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
Lewis, T.S., Shapiro, P.S. and Ahn, N.G. (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res., 74, 49-139.
-
(1998)
Adv. Cancer Res.
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
18
-
-
0028935270
-
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
-
Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J. and Davis, R.J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem., 270, 7420-7426.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7420-7426
-
-
Raingeaud, J.1
Gupta, S.2
Rogers, J.S.3
Dickens, M.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
19
-
-
0029803923
-
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
-
Mendelson, K., Contois, L., Tevosian, S., Davis, R. and Paulson, K. (1996) Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc. Natl Acad. Sci. USA, 93, 12908-12913.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 12908-12913
-
-
Mendelson, K.1
Contois, L.2
Tevosian, S.3
Davis, R.4
Paulson, K.5
-
20
-
-
0029983730
-
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
-
Beyaert, R., Cuenda, A., Vanden Berghe, W., Plaisance, S., Lee, J.C., Haegeman, G., Cohen, P. and Fiers, W. (1996) The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J., 15, 1914-1923.
-
(1996)
EMBO J.
, vol.15
, pp. 1914-1923
-
-
Beyaert, R.1
Cuenda, A.2
Vanden Berghe, W.3
Plaisance, S.4
Lee, J.C.5
Haegeman, G.6
Cohen, P.7
Fiers, W.8
-
21
-
-
0032488837
-
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor
-
Vanden Berghe, W., Plaisance, S., Boone, E., De Bosscher, K., Schmitz, M.L., Fiers, W. and Haegeman, G. (1998) p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem., 273, 3285-3290.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3285-3290
-
-
Vanden Berghe, W.1
Plaisance, S.2
Boone, E.3
De Bosscher, K.4
Schmitz, M.L.5
Fiers, W.6
Haegeman, G.7
-
22
-
-
0028884033
-
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi, D.R., Cuenda, A., Cohen, P., Dudley, D.T. and Saltiel, A.R. (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem., 270, 27489-27494.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
23
-
-
0028988138
-
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
-
Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R. and Lee, J.C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364, 229-233.
-
(1995)
FEBS Lett.
, vol.364
, pp. 229-233
-
-
Cuenda, A.1
Rouse, J.2
Doza, Y.N.3
Meier, R.4
Cohen, P.5
Gallagher, T.F.6
Young, P.R.7
Lee, J.C.8
-
24
-
-
0015752890
-
Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion
-
Seglen, P.O. (1973) Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp. Cell Res., 82, 391-398.
-
(1973)
Exp. Cell Res.
, vol.82
, pp. 391-398
-
-
Seglen, P.O.1
-
25
-
-
0029776373
-
Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis
-
James, N. and Roberts, R. (1996) Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis. Carcinogenesis, 17, 1623-1632.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1623-1632
-
-
James, N.1
Roberts, R.2
-
26
-
-
0021162022
-
Factors influencing peroxisome proliferation in cultured rat hepatocytes
-
Mitchell, A.M., Bridges, J.W. and Elcombe, C.R. (1984) Factors influencing peroxisome proliferation in cultured rat hepatocytes. Arch. Toxicol., 55, 239-246.
-
(1984)
Arch. Toxicol.
, vol.55
, pp. 239-246
-
-
Mitchell, A.M.1
Bridges, J.W.2
Elcombe, C.R.3
-
27
-
-
0033545612
-
Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts
-
Swanton, E., Savory, P., Cosulich, S., Clarke, P. and Woodman, P. (1999) Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts. Oncogene, 18, 1781-1787.
-
(1999)
Oncogene
, vol.18
, pp. 1781-1787
-
-
Swanton, E.1
Savory, P.2
Cosulich, S.3
Clarke, P.4
Woodman, P.5
-
28
-
-
0031714877
-
SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes
-
Manthey, C.L., Wang, S.W., Kinney, S.D. and Yao, Z. (1998) SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes. J. Leukocyte Biol., 64, 409-417.
-
(1998)
J. Leukocyte Biol.
, vol.64
, pp. 409-417
-
-
Manthey, C.L.1
Wang, S.W.2
Kinney, S.D.3
Yao, Z.4
-
29
-
-
0030965266
-
Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells
-
Rokos, C. and Ledwith, B. (1997) Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cells. J. Biol. Chem., 272, 13452-13457.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13452-13457
-
-
Rokos, C.1
Ledwith, B.2
-
30
-
-
0033389528
-
Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor a priming and EGF receptor tyrosine kinase activity
-
Chevalier, S., Macdonald, N. and Roberts, R.A. (1999) Induction of DNA replication by peroxisome proliferators is independent of both tumour necrosis factor a priming and EGF receptor tyrosine kinase activity. J. Cell Sci., 112, 4785-4791.
-
(1999)
J. Cell Sci.
, vol.112
, pp. 4785-4791
-
-
Chevalier, S.1
Macdonald, N.2
Roberts, R.A.3
-
31
-
-
0028997684
-
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
-
Lee, S.S., Pineau, T., Drago, J., Lee, E.J., Owens, J.W., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H. and Gonzalez, F.J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol., 15, 3012-3022.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3012-3022
-
-
Lee, S.S.1
Pineau, T.2
Drago, J.3
Lee, E.J.4
Owens, J.W.5
Kroetz, D.L.6
Fernandez-Salguero, P.M.7
Westphal, H.8
Gonzalez, F.J.9
-
32
-
-
0029784760
-
The peroxisome proliferator-activated receptor alpha is a phosphoprotein: Regulation by insulin
-
Shalev, A., Siegrist-Kaiser, C.A., Yen, P.M., Wahli, W., Burger, A.G., Chin, W.W. and Meier, C.A. (1996) The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology, 137, 4499-4502.
-
(1996)
Endocrinology
, vol.137
, pp. 4499-4502
-
-
Shalev, A.1
Siegrist-Kaiser, C.A.2
Yen, P.M.3
Wahli, W.4
Burger, A.G.5
Chin, W.W.6
Meier, C.A.7
-
33
-
-
0030771852
-
DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region
-
Juge-Aubry, C., Pernin, A., Favez, T., Burger, A., Wahli, W., Meier, C. and Desvergne, B. (1997) DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region. J. Biol. Chem., 272, 25252-25259.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 25252-25259
-
-
Juge-Aubry, C.1
Pernin, A.2
Favez, T.3
Burger, A.4
Wahli, W.5
Meier, C.6
Desvergne, B.7
-
34
-
-
0030964085
-
Regulation of PPAR gamma activity by MAP kinase
-
Camp, H. and Tafuri, S. (1997) Regulation of PPAR gamma activity by MAP kinase. J. Biol. Chem., 272, 10811-10816.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10811-10816
-
-
Camp, H.1
Tafuri, S.2
-
35
-
-
0030576907
-
Evaluation of human cytokine production and effects of pharmacological agents in a heterologous system in vivo
-
Griswold, D.E., Hillegass, L.M., O'Leary-Bartus, J., Lee, J.C., Laydon, J.T. and Torphy, T.J. (1996) Evaluation of human cytokine production and effects of pharmacological agents in a heterologous system in vivo. J. Immunol. Methods, 195, 1-5.
-
(1996)
J. Immunol. Methods
, vol.195
, pp. 1-5
-
-
Griswold, D.E.1
Hillegass, L.M.2
O'Leary-Bartus, J.3
Lee, J.C.4
Laydon, J.T.5
Torphy, T.J.6
-
36
-
-
0029148637
-
2-generating peroxisomal fatty acyl-CoA oxidase
-
2-generating peroxisomal fatty acyl-CoA oxidase. Proc. Natl Acad. Sci. USA, 92, 7080-7084.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7080-7084
-
-
Chu, S.1
Huang, Q.2
Alvares, K.3
Yeldandi, A.4
Rao, M.5
Reddy, J.6
-
37
-
-
0033593225
-
Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
-
Uchida, K., Shiraishi, M., Naito, Y., Torii, Y., Nakamura, Y. and Osawa, T. (1999) Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J. Biol. Chem., 274, 2234-2242.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2234-2242
-
-
Uchida, K.1
Shiraishi, M.2
Naito, Y.3
Torii, Y.4
Nakamura, Y.5
Osawa, T.6
|