Mitochondrial dysfunction a pathogenetic factor in Parkinson's disease

Journal of Neurology, Supplement

Volumn 247, Issue 2, 2000, Pages 63-68

  Reichmann, Heinz ^a   Janetzky, Bernd ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Complex I; Mitochondrial cytopathy; Parkinson's disease; Respiratory chain

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

CONFERENCE PAPER; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; HUMAN; MITOCHONDRIAL RESPIRATION; PARKINSON DISEASE; PRIORITY JOURNAL; RESPIRATORY CHAIN; SUBSTANTIA NIGRA;

ANIMALS; HUMANS; MITOCHONDRIAL MYOPATHIES; PARKINSON DISEASE;

EID: 0034006915     PISSN: 09391517     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (48)

1. Ben-Shachar D, Eshel G, Riederer P, Youdim MBH (1992) Role of iron and iron chelation in dopaminergic-induced neurodegeneration: implication for Parkinson's disease. Ann Neurol 32: S105-S110
2. Benecke R, Strümper P, Weiss H (1993) Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes. Brain 116: 1451-1463
3. Bindoff LA, Birch Machin M, Cartlidge NE, Parker WD Jr, Turnbull DM (1989) Mitochondrial function in Parkinson's disease. Lancet 2(8649): 49
4. Blake CI, Spitz E, Leehey M, Hoffer BJ, Boyson SJ (1997) Platelet mitochondrial respiratory chain function in Parkinson's disease. Mov Disord 12: 3-8
5. Brown MD, Shoffner JM, Kim YL, Jun AS, Graham BH, Cabell MF, Gurley DS, Wallace DC (1996) Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patients. Am J Med Genet 61:283-289
6. Dawson TM, Dawson VL, Snyder SH (1992) A novel messenger molecule in brain: the free radical, nitric oxide. Ann Neurol 32:297-311
7. Dexter DT, Wells FR, Agid F, Lees AJ, Jenner P, Marsden CD (1987) Increased nigral iron content in post mortem parkinsonian brain. Lancet 2(8569):1219-1220
8. Earle KM (1968) Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed tissue. J Neuropathol Exp Neurol 27:1-14
9. Egger J, Lake BD, Wilson J (1981) Mitochondrial cytopathy. A multisystem disorder with ragged-red fibers on muscle biopsy. Arch Dis Child 56: 741-752
10. Götz ME, Freyberger A, Riederer P (1990) Oxidative stress: a role in the pathogenesis of Parkinson's disease. J Neural Transm (Suppl) 29:241-249
11. Gu M, Gash MT, Mann VM, Javoy-Agid F, Cooper JM, Schapira AH (1996) Mitochondrial defect in Huntington's disease caudate nucleus. Ann Neurol 39:385-389
12. Gu M, Cooper JM, Taanman JW, Schapira AHV (1998) Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol 44:177-186
13. Gu M, Owen AD, Toffa SE, Cooper JM, Dexter DT, Jenner P, Marsden CD, Schapira AH (1998) Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases. J Neurol Sci 158:24-29
14. Haas RH, Nasirian F, Nakano K, Ward D, Pay M, Hill R, Shults CW (1995) Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann Neurol 37:714-722
15. Hattori N, Tanaka M, Ozawa T, Mizuno Y (1991) Immunohistochemical studies on complexes I, II, III and IV of mitochondria in Parkinson's disease. Ann Neurol 30:563-571
16. Ikebe SI, Tanaka M, Ohno K, Sato W, Hattori K, Kondo T, Mizuno Y, Ozawa T (1990) Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem Biophys Res Commun 170:1044-1048
17. Ikebe S, Tanaka M, Ozawa T (1995) Point mutations of mitochondrial genome in Parkinson's disease. Mol Brain Res 28:281-295
18. Janetzky B, Hauck S, Youdim MB, Riederer P, Jellinger K, Pantucek F, Zöchling R, Boissl KW, Reichmann H (1994) Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease. Neurosci Lett 169:126-128
19. Kösel S, Egensherger R, Schnopp NM, Graeber MB (1997) The 'common deletion' is not increased in Parkinsonian substantia nigra as shown by competitive PCR. Mov Disord 12:639-645
20. Krige D, Carroll MT, Cooper JM, Marscien CD, Schapira AH (1992) Platelet mitochondrial function in Parkinson's disease. Ann Neurol 32: 782-788
21. Lestienne P, Nelson J, Riederer P, Jellinger K, Reichmann H (1990) Normal mitochondrial genome in brain from patients with Parkinson's disease and complex 1 detect. J Neurochem 55: 1810-1812
22. Lestienne P, Nelson J, Riederer P, Reichmann H, Jellinger K (1991) Mitochondrial DNA in postmortem brain from patients with Parkinson's disease. J Neurochem 56:1819
23. Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B (1962) A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control. A correlated clinical, biochemical and morphological study. J Clin Invest 41: 1776-1804
24. Mann VM, Cooper JM, Schapira AHV (1992) Quantitation of a mitochondrial DNA deletion in Parkinson's disease. FEBS Lett 299:218-222
25. Mann VM, Cooper JM, Krige D, Daniel SE, Schapira AH, Marsden CD (1992) Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease. Brain 115:333-342
26. Mizuno Y, Sone N, Saitoh T (1987) Effects of 1-methyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-pyridinium ion on activities of the enzymes in the electron transport system in mouse brain. J Neurochem 48: 1787-1793
27. Mizuno Y, Ohta S, Tanaka M, Takamiya S, Suzuki K, Sato T, Oya H, Ozawa T, Kagawa Y (1989) Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 163: 1450-1455
28. Mizuno Y, Suzuki K, Ohta S (1990) Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease. J Neurol Sci 96:49-57
29. Nicklas WJ, Vyas I, Heikkila RE (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-melhyl-4-phenylpyridine, a metabolite of the neurotoxic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 36: 2503-2508
30. Olanow CW (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16:439-456
31. Ozawa T, Tanaka M, Ikebe S, Ohno K, Kondo T, Mizuno Y (1990) Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis. Biochem Biophys Res Commun 172:483-489
32. Ozawa T, Tanaka M, Ino H, Ohno K, Sano T, Wada Y, Yoneda M, Tanno Y, Miyatake T, Tanaka T, Itoyama S, Ikebe SI, Hattori N, Mizuno Y (1991) Distinct clustering of point mutations in mitochondrial DNA among patients with mitochondrial encephalomyopathies and with Parkinson's disease. Biochem Biophys Res Commun 176: 938-946
33. Parker WD, Boyson SJ, Parks JK (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-723
34. Penn AMW, Roberts T, Hodder J, Allen PS, Zhu G, Martin WR (1995) Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle. Neurology 45:2097-2099
35. Przedborski S, Jackson Lewis V, Muthane U, Jiang H, Ferriera M, Naini AB, Fahn S (1993) Chronic levodopa administration alters cerebral mitochondrial respiratory chain activity. Ann Neurol 34:715-723
36. Reichmann H, Hoppeler H, Mathieu-Costello O, von Bergen F, Pette D (1985) Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits. Eur J Physiol (Pflüger's Arch) 404:1-9
37. Reichmann H, Riederer P (1989) Biochemische Analyse der Atmungskettenkomplexe verschiedener Hirnregionen von Patienten mit Morbus Parkinson. In: Symposium des BMFT Morbus Parkinson und andere Basalganglienerkrankungen. p 44 (Abstract)
38. Reichmann H, Riederer P, Seufert S (1990) Disturbances of the respiratory chain in brain from patients with Parkinson's disease. Mov Disord 5: 28
39. Reichmann H, Janetzky B, Bischof F, Seibel P, Schöls L, Kuhn W, Przuntek H (1994) Unaltered respiratory chain enzyme activity and mitochondrial DNA in skeletal muscle from patients with idiopathic Parkinson's syndrome. Eur Neurol 34:263-267
40. Sanchez-Ramos JR, Överik E, Ames BN (1994) A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain. Neurodegeneration 3:197-204
41. Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD (1989) Mitochondrial complex I deficiency in Parkinson's disease (letter). Lancet 1(8649):1269
42. Schapira AHV, Holt IJ, Sweeney M, Harding AE, Jenner P, Marsden CD (1990) Mitochondrial DNA analysis in Parkinson's disease. Mov Disord 5: 294-297
43. Schapira AH, Mann VM, Cooper JM, Dexter D, Daniel SE, Jenner P, Clark JB, Marsden CD (1990) Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem 55: 2142-2145
44. Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC (1991) Mitochondrial oxidative phosphorylation defects in Parkinson's disease. Ann Neurol 30 (3):332-339 .
45. Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds GP, Hebenstreit G, Youdim MB (1988) Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J Neural Transm 74:199-205
46. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP Jr, Davis RE, Parker WD Jr (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40: 663-671
47. Taylor DJ, Krige D, Bames PR, Kemp GJ, Carroll MT, Mann VM, Cooper JM, Marsden CD, Schapira AH (1994) A 31P magnetic resonance spectroscopy study of mitochondrial function in skeletal muscle of patients with Parkinson's disease. J Neurol Sci 125(1):77-81
48. Yoshino H, Nakagawa-Hattori Y, Kondo T, Mizuno Y (1992) Mitochondrial complexes I and II activities of lymphocytes and platelets in Parkinson's disease. J Neural Transm 4:27-34