Effect of Withania somnifera on lysosomal acid hydrolases in adjuvant- induced arthritis in rats

Pharmacy and Pharmacology Communications

Volumn 6, Issue 4, 2000, Pages 187-190

  Rasool, Mahaboobkhan ^a   Latha, Lenin Mary ^a   Varalakshmi, Palaninathan ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; INDOMETACIN; LYSOSOME ENZYME; WITHANIA SOMNIFERA EXTRACT;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG FORMULATION; DRUG MECHANISM; ENZYME ACTIVITY; NONHUMAN; PAW EDEMA; POWDER; RAT; RHEUMATOID ARTHRITIS;

EID: 0034006581     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080800128735863     Document Type: Article

References (20)

1. Agha, M. A., Gad, Z. M. (1995) Lipid peroxidation and lysosomal integrity in different inflammatory models in rats. The effect of indomethacin and naptazone. Pharmacol. Res. 32: 279-285
2. Anbalagan, K., Sadique, J. (1981) Influence of an Indian medicine (Ashwagandha) on acute phase reactants in inflammation. Ind. J. Exp. Biol. 19: 245-249
3. Anderson, A. J. (1970) Lysosomal enzyme activity in rats with adjuvant-induced arthritis. Ann Rheum. Dis. 29: 307-313
4. Buddhiraja, R. D., Sudhir, S. (1987) Review of biological activity of withanolides. J. Sci. Ind. Res. 46: 488-491
5. Carevic, O., Djokic. S. (1988) Comparative studies on the effects of erythromycin A and azithromycin upon extracellular release of lysosomal enzymes in inflammatory process. Agents Actions 25: 124-131
6. Etherington, D. J. (1972) The nature of the collagenolytic Cathepsin-D of rat liver and its distribution in other rat tissues. Biochem. J. 127: 685-692
7. Geetha, T., Varalakshmi, P. (1998) Anti-inflammatory activity of lupeol and lupeol linoleate in adjuvant-induced arthritis. Fitoterapia 69: 13-19
8. Kamath, R., Rao, B. S. S., Uma Devi, P. (1999) Response of a mouse fibrosarcoma to withaferin A and radiation. Pharm. Pharmacol. Commun. 5: 287-291
9. Kawai, Y., Anno, K. (1971) Mucopolysaccharide-degrading enzymes from the liver of the squid, Ommastrephes slonaipacificus. I. Hyaluronidase. Biochim. Biophys. Acta 242: 428-436
10. King, J. C. (1965) The phosphorus. In: Van, D. (ed) Practical Clinical Enzymology, Nostrand, London, pp 191-208
11. Kweifio-Okai, G., Carroll, C. A. (1992) Anti-arthritic effect of Alstonia boonei triterpenes. In: Gopalakrishnakone, P., Tan, C. K. (eds) Recent Advances in Toxicology Research. 3rd edn, VTRG, Singapore, pp 19-26
12. Kweifio-Okai, G., Carroll, C. A. (1993) Anti-arthritic effect of lupeol acetate. Phytother. Res. 7: 213-215
13. Lowry, O. H., Rosebrough, N. J., Farr, A. I., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
14. Marhun, D. (1976) Rapid colorimetric assay of β-galactosidase and N-acetyl-β-galactosaminidase in human urine. Clin. Chim. Acta 73: 453-461
15. Sharma, K., Dandiya, P. C. (1991) Withania somnifera (Dunal). Present status. Indian Drugs 29: 247-250
16. Sharma, S., Dahanukar, S., Karandikar, S. M. (1985) Effect of long-term administration of the roots of Ashwagandha and Shatavari in rats. Indian Drugs 23: 133-139
17. Subrata, D., Ravishankar, B., Bhausar, G. C. (1994) Investigation of the anti-inflammatory effects of Paederia foetida. J. Ethnopharmacol. 43: 31-38
18. Weissmann, G. (1972) Lysosomal mechanisms of tissue injury in arthritis. New Engl. J. Med. 286: 141-147
19. Ziauddin, M., Phansalkar, N., Patki, P., Diwanay, S., Patwardhan, B. (1996) Studies on the immunomodulatory effects of Ashwagandha. J. Ethnopharmacol. 50: 69-76
20. Zurier, R. B., Hoffstein, S., Weissmann, G. (1973) Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins. Arthritis Rheum. 16: 606-618