Augmentative effects of L-cysteine and methylmethionine sulfonium chloride on mucin secretion in rabbit gastric mucous cells

Journal of Gastroenterology and Hepatology (Australia)

Volumn 15, Issue 1, 2000, Pages 45-52

  Watanabe, Tomoe ^a,b   Ohara, Susumu ^a   Miyazawa, Shitirou ^a   Saigenji, Katunori ^a   Hotta, Kyoko ^a  

^a KITASATO UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

L cysteine; Mucin secretion; Rabbit gastric mucous cells; Soybean agglutinin lectin; Sulfhydryl compounds

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; ADENOSINE TRIPHOSPHATE; BOVINE SERUM ALBUMIN; CALCIUM ION; CYCLIC AMP; CYSTEINE; EDETATE SODIUM; FURA 2 ACETOXYMETHYL ESTER; S METHYLMETHIONINE; SOYBEAN AGGLUTININ; STOMACH MUCIN;

ANIMAL CELL; ARTICLE; CELL GRANULE; CELL SECRETION; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MUCOUS CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; STOMACH GLAND; STOMACH MUCOSA; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0034006059     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2000.02037.x     Document Type: Article

References (32)

1. 1 Shapiro SK. The biosynthesis of methionine from homocysteine and methylmethionine sulfonium salt. Biochem. Biophys. Acta 1955; 18: 134-5.
2. 2 Finkelstein JD. Methionine metabolism in mammals. J. Nutr. Biochem. 1990; 1: 228-37.
3. 3 Cooper AJL. Biochemistry of sulfur-containing amino acids. Ann. Rev. Biochem. 1983; 52: 187-222.
4. 4 Watanabe T, Ohara S, Ichikawa T, Saigenji K, Hotta K. Mechanisms for cytoprotection by vitamin U from ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci. 1996; 41: 49-54.
5. 5 Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate gastric cytoprotection. Science 1981; 214: 200-2.
6. 6 Szelenyi I, Brune K. Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide. Dig. Dis. Sci. 1986; 31: 1207-10.
7. 7 Rogers C, Brown A, Szabo S. Gastric mucosal protection by new aryl sulfhydryl drugs. Dig. Dis. Sci. 1988; 33: 324-9.
8. 8 Loguercio C, Taranto D, Beneduce F et al. Glutathione prevents ethanol induced gastric mucosal damage and depletion of sulfhydryl compounds in humans. Gut 1993; 34: 161-5.
9. 9 Hiraishi H, Terano A, Ota S et al. Protection of cultured rat gastric cells against oxidant induced damage by exogenous glutathione. Gastroenterology 1994; 106: 1199-207.
10. 10 Takeuchi K, Nishiwaki H, Ishihara Y, Okabe S. Roles of gastric motility changes in cytoprotection induced by acetazolamide and cysteamine in rats. Jpn. J. Pharmacol. 1987; 44: 269-81.
11. 11 Takeuchi K, Okada M, Niida H, Okabe S. Role of sulfhydryls in mucosal injury caused by ethanol: Relation to microvascular permeability, gastric motility and cytoprotection. J. Pharmacol. Exp. Ther. 1989; 248: 836-41.
12. 12 Szabo S. Role of sulfhydryls and early vascular lesion in gastric mucosal injury. Acta Physiol. Hung. 1984; 64: 203-14.
13. 2 or sodium thiosulfate. Gastroenterology 1986; 91: 1415-26.
14. 14 Trier JS, Szabo S, Allan CH. Ethanol-induced damage to mucosal capillaries of rat stomach. Gastroenterology 1987; 92: 13-22.
15. 15 Mutoh M, Hiraishi H, Ota S et al. Protective role of intra-cellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells. Gastroenterology 1990; 98: 1452-9.
16. 16 Romano M, Razandi M, Raza A, Szabo S, Ivey J. Cysteamine protects gastric epithelial cell monolayers against drug induced damage. evidence for direct cellular protection by sulfhydryl compounds. Gut 1992; 33: 30-8.
17. 2β stimulate rat gastric mucin release. Gastroenterology 1983; 84: 306-13.
18. 18 Takahashi S, Okabe S. Stimulatory effects of sucralfate on secretion and synthesis of mucus by rabbit gastric mucosal cells. Involvement of phospholipase C. Dig. Dis. Sci. 1996; 41: 498-504.
19. 19 Kuver R, Savard C, Oda D, Lee SP. PGE generates intra-cellular cAMP and accelerates mucin secretion by cultured dog gallbladder epithelial cells. Am. J. Physiol. 1994; 267: G998-1003.
20. 2 purinergic receptor regulation of mucus glycoprotein secretion by rabbit gastric mucous cells in a primary culture. Gastroenterology 1994; 106: 1485-92.
21. 21 Watanabe S, Wang X, Hirose M et al. Basic fibroblast growth factor accelerates gastric mucosal restoration in vitro by promoting mesenchymal cell migration and proliferation. J. Gastroenterol. Hepatol. 1995; 10: 627-32.
22. 22 Azuumi Y, Ichikawa T, Ishihara K, Hotta K. The validity of the ethanol precipitation method for the measurement of mucin content in human gastric juices and its possible relationship to gastroduodenal diseases. Clin. Chim. Acta 1993; 221: 219-25.
23. 23 Ohara S, Ishihara K, Hotta K. Comparative study on mucus glycoproteins in rat stomach and duodenum. Comp. Biochem. Physiol. 1986; 83B: 273-5.
24. 24 Roughley PJ, White RJ. The use of caesium sulphate density gradient centrifugation to analyse proteoglycans from human articular cartilages of different ages. Biochem. Biophys. Acta 1983; 759: 58-66.
25. 25 Ohara S, Watanabe T, Hotta K. Comparative study of carbohydrate portion of gastrointestinal mucins using enzyme-linked lectin-binding assay (ELLA). Comp. Biochem. Physiol. 1997; 116B: 167-72.
26. 2+ in cultured rat mesangial cells. Life Sci. 1994; 55: 365-70.
27. 27 Ohara S, Ishihara K, Hotta K. Regional differences in pig gastric mucins. Comp. Biochem. Physiol. 1993; 106B: 153-8.
28. 28 Seidler U, Knafla K, Kownatzki R, Sewing KF. Effects of endogenous and exogenous prostaglandins on glycoprotein synthesis and secretion in isolated rabbit gastric mucosa. Gastroenterology 1988; 95: 945-51.
29. 2+-dependent and independent secretagogue action on gastric mucus secretion in rabbit mucosal explants. Am. J. Physiol. 1989; 256: G739-46.
30. 30 Forstner JF, Forstner GG. Gastrointestinal mucus. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven Press, 1994; 1255-83.
31. 31 Rodriguez L, Stirling CJ, Woodman PG. Multiple N-ethylmaleimide-sensitive components are required for endosomal vesicle fusion. Mol. Biol. Cell. 1994; 5: 773-83.
32. 32 Sokoloff AV, Whalley T, Zimmerberg J. Characterization of N-ethylmaleimide-sensitive thiol groups required for the GTP-dependent fusion of endoplasmic reticulum membranes. Biochem. J. 1995; 312: 23-30.