Preservation of cerebrovascular tone and reactivity by sodium channel inhibition in experimental prolonged asphyxia in piglets

Pediatric Research

Volumn 47, Issue 3, 2000, Pages 376-380

  Levine, Vladimir ^a,b   Pourcyrous, Massroor ^a   Bada, Henrietta S ^a   Parfenova, Helena ^a   Yang, Wenjian ^c   Korones, Sheldon B ^a   Leffler, Charles W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Newborn Center   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARIPORIDE; CYCLIC AMP; ISOPRENALINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY DILATATION; ARTICLE; ASPHYXIA; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; BRAIN BLOOD VESSEL; BRAIN HYPOXIA; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; LUNG MINUTE VOLUME; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; SECOND MESSENGER; SWINE;

EID: 0034004245     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/00006450-200003000-00015     Document Type: Article

References (37)

1. duPlessis AJ, Johnston MV 1997 Hypoxic-ischemic brain injury in the newborn: cellular mechanisms and potential strategies for neuroprotection. Clin Perinatol 24:627-655
2. Pasternak JF 1993 Hypoxic-ischemic brain damage in the term infant. Pediatr Clin North Am 40:1061-1072
3. Lou HC 1998 Autoregulation of cerebral blood flow and brain lesions in newborn infants. Lancet 352:1406
4. Paulson OB, Strandgaard S, Edvinsson L 1990 Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2:161-193
5. Pourcyrous M, Parfenova H, Bada HS, Korones SB, Leffler CW 1997 Changes in cerebral cyclic nucleotides and cerebral blood flow during prolonged asphyxia and recovery in newborn pigs. Pediatr Res 41:617-623
6. Parfenova H, Shibata M, Zuckerman S, Mirro R, Leffler CW 1993 Cyclic nucleotides and cerebrovascular tone in newborn pigs. Am J Physiol 265:H1972-H1982
7. Parfenova H, Leffler CW 1996 Effects of hypercapnia on prostanoid and cAMP production of cerebral microvascular cell cultures. Am J Physiol 270:C1503-C1510
8. 2 and cerebral circulation in newborn pigs: cyclic nucleotides and prostanoids in vascular regulation. Am J Physiol 226:H1494-H1501
9. Rudman D, Fleischer A, Kutner MH 1976 Concentration of 3′,5′-cyclic adenosine monophosphate in ventricular cerebrospinal fluid of patients with prolonged coma after heart trauma or intracranial hemorrhage. N Engl J Med 295:635-638
10. Pourcyrous M, Bada H, Yang W, Parfenova H, Wong SP, Korones SB, Leffler CW 1999 Prognostic significance of cerebrospinal fluid adenosine monophosphate in neonatal asphyxia. J Pediatr 134:90-96
11. Urenjak J, Obrenovitch TP 1996 Pharmacological modulation of voltage-gated Na+ channels: a rational and effective strategy against ischemic brain damage. Pharmacol Rev 48:21-67
12. Taylor CP, Meldrum BS 1995 Na+ channels as targets for neuroprotective drugs. Trends Pharmacol Sci 16:309-316
13. Costa MR, Catterall WA 1984 Cyclic AMP-dependent phosphorylation of the alpha subunit of the sodium channel in synaptic nerve ending particles. J Biol Chem 259:8210-8218
14. Rossie S, Catterall WA 1984 AMP-dependent phosphorylation of voltage-sensitive sodium channel in primary cultures of red brain neurons. J Biol Chem 262:12735-12744
15. Lee M, Vest JW, Lai Y, Scheuer T, Catterall WA 1992 Functional modulation of brain sodium channels by cAMP-dependent phosphorylation. Neuron 8:1151-1159
16. Cummins TR, Xia Y, Haddad GG 1993 Human neocortical excitability is decreased during anoxia via sodium channel modulation. J Clin Invest 91:608-615
17. Perez-Pinzon MA, Chan CY, Rosenthal M, Sick TJ 1992 Membrane and synaptic activity during anoxia in the isolated turtle cerebellum. Am J Physiol 263:R1057-R1063
18. Parer JT 1994 Fetal cerebral metabolism. The influence of asphyxia and other factors. J Perinatol 15:376-385
19. Altman DL, Perlman JM, Volpe JJ, Powers WJ 1993 Cerebral oxygen metabolism in newborns. Pediatrics 92:99-104
20. Powers WJ, Grubb RL, Darriet D, Raichle ME 1985 Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 5:600-608
21. Borch K, Greisen G 1998 Blood flow distribution in the normal human preterm brain. Pediatr Res 43:228-233
22. Rosenbaum JL, Altman D, Cole FS, Yundt K, Levine V, Powers WJ 1996 Low cerebral blood flow correlates with good neurological outcome among survival of neonatal hypoxic-ischemic encephalopathy. Pediatr Res 39:227A(abstr)
23. Fellow LK, Boutelle LK, Fillenz M 1993 Physiological stimulation increases non-oxidative glucose metabolism in the brain of the freely moving rat. J Neurochem 59:1258-1263
24. Taylor DL, Richards DA, Obrenovitch TP, Symon L 1994 Time course of changes in extracellular lactate evoked by transient K+-induced depolarization in the rat striatum. J Neurochem 62:23368-23374
25. Leffler CW, Smith JS, Edrington JL, Zuckerman SL, Parfenova H 1997 Mechanisms of hypoxia-induced cerebrovascular dilation in the newborn pig. Am J Physiol 272:H1323-H1332
26. Kobayashi M, Lust WD, Passonneau JV 1997 Concentrations of energy metabolites and cyclic nucleotides during and after bilateral ischemia in the gerbil cerebral cortex. J Neurochem 29:53-59
27. Leffler CW 1997 Prostanoids: intrinsic modulators of cerebral circulation. News Physiol Sci 12:72-77
28. Rosenblum WI 1998 In vivo evidence that an adenylate cyclase-cAMP system dilates cerebral arterioles in mice. Stroke 19:888-891
29. Lou HC, Lassen NA, Tweed WA, Johnson G, Jones M, Palahniuk RJ 1979 Pressure passive cerebral blood flow breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatr Scand 68:57-62
30. Beller FK 1995 The cerebral palsy: a catastrophic misunderstanding in obstetrics. Obstet Gynecol 50:83
31. Brann AWA, Myers RE 1975 Central nervous system findings in the newborn monkey severe in utero partial asphyxia. Neurology 25:327-338
32. Myers RE 1972 Two patterns of perinatal brain damage and their conditions of occurrence. Am J Obstet Gynecol 112:246-276
33. Ames A, Wright RL, Kowanda M, Thurston JM, Majino G 1968 Cerebral ischemia II. The no reflow phenomenon. Am J Physiol 52:437-453
34. Van Bel F, Dorrepall CA, Benders MMNL, Zeeuwe PEM, Van de Bor M, Berger HM 1993 Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia. Pediatrics 92:365-372
35. Sankaran K, Peters K, Finer N 1981 Estimated cerebral blood flow in term infants with hypoxic-ischemic encephalopathy. Pediatr Res 15:1415-1418
36. Volpe JJ, Herscovitch P, Perlman JM, Kreusser KL, Raichle ME 1985 Positron emission tomography in the asphyxiated term newborn: parasagittal impairment of cerebral blood flow. Ann Neurol 17:287-296
37. 2 changes, and visual evoked potential in mechanically ventilated preterm infants. Acta Paediatr Scand 76:394-400