The inhibitory effect of KT3-671, a nonpeptide angiotensin-receptor antagonist, on rabbit and rat isolated vascular smooth muscles: A possible involvement of K(ATP) channels

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 3, 2000, Pages 457-467

  Satake, Nobuhiro ^a   Imanishi, Masami ^a,c   Keto, Yoshihiro ^a,d   Ishikawa, Makoto ^a,d   Yamada, Hiroyuki ^a,d   Shibata, Shoji ^a   Tomiyama, Akira ^b  

^a UNIVERSITY OF HAWAII   (United States)

^b Kotobuki Seiyaku Co Ltd   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Angiotensin II; Insurmountable antagonist; K(ATP) channels; KT3 671; Rabbit; Rat; Vascular smooth muscle

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 4 AMINOPYRIDINE; 4,5,6,7 TETRAHYDRO 8 OXO 2 PROPYL 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL]CYCLOHEPTIMIDAZOLE; 9,11 EPITHIO 11,12 METHANOTHROMBOXANE A2; ADENOSINE TRIPHOSPHATE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BARIUM CHLORIDE; CANDESARTAN; IBERIOTOXIN; INDOMETACIN; LOSARTAN POTASSIUM; METHYLENE BLUE; N(G) NITROARGININE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; POTASSIUM ION; PROSTAGLANDIN F2 ALPHA; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG COMPETITION; DRUG EFFECT; KIDNEY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; IMIDAZOLES; MALE; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNELS; RABBITS; RATS; RATS, WISTAR; RECEPTORS, ANGIOTENSIN; SPECIES SPECIFICITY; TETRAZOLES; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 0034003978     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200003000-00017     Document Type: Article

References (4)

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3. Ondetti MA, Cushman DW. Inhibition of renin-angiotensin system: a new approach to the therapy of hypertension. J Med Chem 1981;24:355-61.
4. Patchett A, Harris E, Tristram E, et al. A new class of angiotensin converting enzyme inhibitors. Nature 1980;288:280-3.