Impact of atropine injection on heart rate response during treadmill exercise echocardiography: A double-blind randomized pilot study

Echocardiography

Volumn 17, Issue 3, 2000, Pages 221-227

  Attenhofer Jost, Christine H ^a   Pellikka, Patricia A ^a   McCully, Robert B ^a   Roger, Veronique L ^a   Oh, Jae K ^a   Hepner, Anne M ^a   Seward, James B ^a  

^a MAYO CLINIC   (United States)

Author keywords

Atropine; Exercise testing; Stress echocardiography

Indexed keywords

ATROPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INDUCED DISEASE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; HEART RATE; HEART VENTRICLE WALL MOTION; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STRESS ECHOCARDIOGRAPHY; TRANSLUMINAL CORONARY ANGIOPLASTY; TREADMILL EXERCISE; XEROSTOMIA;

EID: 0034003871     PISSN: 07422822     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8175.2000.tb01129.x     Document Type: Article

References (18)

1. 1. Armstrong WF: Stress echocardiography for detection of coronary artery disease. Circulation 1991;84(suppl 3):I43-I49.
2. 2. Roger VL, Pellikka PA, Oh JK, et al: Stress echocardiography. Part I. Exercise echocardiography: Techniques, implementation, clinical applications, and correlations. Mayo Clin Proc 1995;70:5-15.
3. 3. Ling LH, Pellikka PA, Mahoney DW, et al: Atropine augmentation in dobutamine stress echocardiography: Role and incremental value in a clinical practice setting. J Am Coll Cardiol 1996;28:551-557.
4. 4. Marraccini P, Orsini E, Nassi G, et al: Effects of parasympathetic blockade on ischemic threshold in patients with exercise-induced myocardial ischemia. Am J Cardiol 1991;68:539-542.
5. 5. Kelbaek H, Marving J, Hvid-Jacobsen K, et al: Effects of atropine on left ventricular volumes and ejection and filling rates at rest and during exercise. Br J Clin Pharmacol 1991;32:585-589.
6. 6. Nyberg G: Vagal and sympathetic contributions to the heart rate at rest and during isometric and dynamic exercise in young healthy men. J Cardiovasc Pharmacol 1981;3:1243-1250.
7. 7. Ekblom B, Goldbarg AN, Kilbom A, et al: Effects of atropine and propranolol on the oxygen transport system during exercise in man. Scand J Clin Lab Invest 1972;30:35-42.
8. 8. Savin WM, Davidson DM, Haskell WL: Autonomic contribution to heart rate recovery from exercise in humans. J Appl Physiol 1982;53: 1572-1575.
9. 9. Kamimori GH, Smallridge RC, Redmond DP, et al: The effect of exercise on atropine pharmacokinetics. Eur J Clin Pharmacol 1990;39:395-397.
10. 10. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms: Schiller NB, Shah PM, Crawford M, et al: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 1989;2:358-367.
11. 11. Amico AF, Lichtenberg GS, Reisner SA, et al: Superiority of visual versus computerized echocardiographic estimation of radionuclide left ventricular ejection fraction. Am Heart J 1989; 118:1259-1265.
12. 12. Brown JH: Atropine, scopolamine, and related antimuscarinic drug. In Goodman AG, Rall TW, Nies AS, et al (eds): Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed., Pergamon Press, New York, 1990, p. 150.
13. 13. Maciel BC, Gallo L Jr, Marin Neto JA, et al: Autonomic nervous control of the heart rate during dynamic exercise in normal man. Clin Sci (Colch) 1986;71:457-460.
14. 14. Goldstein RE, Karsh RB, Smith ER, et al: Influence of atropine and of vagally mediated bradycardia on the occurrence of ventricular arrhythmias following acute coronary occlusion in closed-chest dogs. Circulation 1973;47: 1180-1190.
15. 15. Cooper MJ, Abinader EG: Atropine-induced ventricular fibrillation: Case report and review of the literature. Am Heart J 1979;97:225-228.
16. 16. Ambrosio G, Betocchi S, Pace L, et al: Prolonged impairment of regional contractile function after resolution of exercise-induced angina: Evidence of myocardial stunning in patients with coronary artery disease. Circulation 1996;94:2455-2464.
17. 17. Gall SA Jr, Maier GW, Glower DD, et al: Recovery of myocardial function after repetitive episodes of reversible ischemia. Am J Physiol 1993;264:H1130-H1138.
18. 18. Landzberg JS, Parker JD, Gauthier DF, et al: Effects of intracoronary acetylcholine and atropine on basal and dobutamine-stimulated left ventricular contractility. Circulation 1994;89: 164-168.