Serum isoforms of bone alkaline phosphatase increase during physical exercise in women

Calcified Tissue International

Volumn 66, Issue 5, 2000, Pages 342-347

  Rudberg, A ^a   Magnusson, P ^b,d   Larsson, L ^b   Joborn, H ^c  

^a LINNAEUS UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c Vastervik Hospital   (Sweden)

^d Jerry L Pettis Memorial VA Medical Center   (United States)

Author keywords

Calcium; Carboxyterminal; Cross linked; Parathyroid hormone; Skeletal sites; Telopeptide; Type I collagen

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; COLLAGEN TYPE 1; PARATHYROID HORMONE;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE MASS; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CORTICAL BONE; EXERCISE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TRABECULAR BONE;

ADULT; ALKALINE PHOSPHATASE; BONE AND BONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; ISOENZYMES; MENOPAUSE; MIDDLE AGED; RUNNING;

EID: 0034003690     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002230010071     Document Type: Article

References (36)

1. Smith EL, Gilligan C (1991) Physical activity effects on bone metabolism. Calcif Tissue Int (suppl) 49:50-54
2. Gutin B, Kasper MJ (1992) Can vigorous exercise play a role in osteoporosis prevention? A review. Osteoporosis Int 2:55-69
3. Brahm H, Piehl-Aulin K, Ljunghall S (1997) Bone metabolism during exercise and recovery: the influence of plasma volume and physical fitness. Calcif Tissue Int 61:192-198
4. Eliakim A, Raisz LG, Brassel JA, Cooper DM (1997) Evidence for increased bone formation following a brief endurance-type training intervention in adolescent males. J Bone Miner Res 12:1708-1713
5. Micklesfield LK, Lambert EV, Fataar AB, Noakes TD, Myburgh KH (1995) Bone mineral density in mature, premenstrual ultramarathon runners. Med Sci Sports Exerc 27:688-696
6. Caillot-Augusseau A, Lafage-Proust MH, Soler C, Pernod J, Dubois F, Alexandre C (1998) Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95). Clin Chem 44:578-585
7. Raisz LG (1995) Physiology of bone. In: Becker KL (ed) Principles and practice of endocrinology and metabolism, 2nd ed. J. B. Lippincott Company, Philadelphia, pp 447-455
8. Fedde KN, Lane CC, Whyte PM (1988) Alkaline phosphatase is an ectoenzyme that acts on micromolar concentrations of natural substrates at physiologic pH in human osteosarcoma. Arch Biochem Biophys 264:400-409
9. Puzas JE (1993) The osteoblast. In: Favus MJ (ed) Primer on the metabolic bone diseases and disorders on mineral metabolism, 2nd ed. American Society for Bone and Mineral Research Res, Chicago, pp 15-21
10. Eriksen EF, Brixen K, Charles P (1995) New markers of bone metabolism: clinical use in metabolic bone disease. Eur J Endocrinol 132:251-263
11. Whyte MP (1994) Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocr Rev 15:439-461
12. Narisawa S, Fröhlander N, Millán JL (1997) Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn 208:432-446
13. Magnusson P, Löfman O, Larsson L (1992) Determination of alkaline phosphatase isoenzymes in serum by high-performance liquid chromatography with post-column reaction detection. J Chromatogr 576:79-86
14. Magnusson P, Löfman O, Larsson L (1993) Methodological aspects on separation and reaction conditions of bone and liver alkaline phosphatase isoform analysis by high-performance liquid chromatography. Anal Biochem 211:156-163
15. Salvesen H, Johansson AG, Foxdal L, Wide K, Piehl-Aulin K, Ljunghall S (1994) Intact serum parathyroid hormone levels increase during running exercise in well-trained men. Calcif Tissue Int 54:256-261
16. Brahm H, Piehl-Aulin K, Ljunghall S (1996) Biochemical markers of bone metabolism during distance running in healthy, regularly exercising men and women. Scand J Med Sci Sports Exerc 6:26-30
17. Thorsen K, Kristoffersson A, Lorentzon R (1996) The effects of brisk walking on markers of bone and calcium metabolism in postmenopausal women. Calcif Tissue Int 58:221-225
18. Thorsen K, Kristoffersson A, Hultdin J, Lorentzon R (1997) Effects of moderate endurance exercise on calcium, parathyroid hormone and markers of bone metabolism in young women. Calcif Tissue Int 60:16-20
19. Gambke B, Berg A, Fabian K, Francaux M, Haber P, Hartmann U, Kamber M, Lormes W, Rosskopf P, Schwarz L, Berger D (1997) Multicenter evaluation of a portable system for determining blood lactate. J Lab Med 21:250-256
20. Magnusson P, Degerblad M, Sääf M, Larsson L, Thorén M (1997) Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like growth factor-I (IGF-I) and during growth hormone therapy in adults with growth hormone deficiency. J Bone Miner Res 12:210-220
21. Flood J, Liedtke R, Mattenheimer H, Rothouse L, Trundle D, Vroon D, Whisler K, Collinsworth W (1990) A multicenter evaluation of the Boehringer Mannheim/Hitachi 717 System. Clin Biochem 23:477-488
22. Nussbaum SR, Zahradnik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY, Keutmann HT, Wang C-A, Potts JT, Segre GV (1987) Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 33:1364-1367
23. Gundberg CM, Wilson PS, Gallop PM, Parfitt AM (1985) Determination of osteocalcin in human serum: results with two kits compared with those by a well-characterized assay. Clin Chem 31:1720-1723
24. Risteli J, Elomaa I, Niemi S, Novamo A, Risteli L (1993) Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin Chem 39:635-640
25. Beamont van W, Strand JC, Petrofsky JS, Hipskind SG, Greenieaf JE (1973) Changes in total plasma content of electrolytes and proteins with maximal exercise. J Appl Physiol 34:102-106
26. Magnusson P, Larsson L, Magnusson M, Davie MWJ, Sharp CA (1999) Isoforms of bone alkaline phosphatase: characterization and origin in human trabecular and cortical bone. J Bone Miner Res 14:1926-1933
27. Anh DJ, Dimai HP, Hall SL, Farley JR (1998) Skeletal alkaline phosphatase activity is primarily released from human osteoblasts in an insoluble form, and the net released is inhibited by calcium and skeletal growth factors. Calcif Tissue Int 62:332-340
28. Bennell KL, Malcolm SA, Khan KM, Thomas SA, Ried SJ, Brunker PD, Ebeling PR, Wark JD (1997) Bone mass and bone turnover in power athletes, endurance athletes, and controls: a 12-month longitudinal study. Bone 20:477-484
29. Magnusson P, Häger A, Larsson L (1995) Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents. Pediatr Res 38:955-961
30. Magnusson P, Löfman O, Toss G, Larsson L (1995) Determination of bone alkaline phosphatase isoforms in serum by a new high performance liquid chromatography assay in patients with metabolic bone disease. Acta Orthop Scand (suppl 266) 66:203-204
31. Magnusson P, Larsson L, Englund G, Larsson B, Strang P, Selin-Sjögren L (1998) Differences of bone alkaline phosphatase isoforms in metastatic bone disease and discrepant effects of clodronate on different skeletal sites indicated by the location of pain. Clin Chem 44:1621-1628
32. Ljunghall S, Joborn H, Roxin L-E, Rastad J, Wide L, Åkerström G (1986) Prolonged low-intensity exercise raises the serum parathyroid hormone levels. Clin Endocrinol 25:535-542
33. Cosman F, Lindsay R (1998) Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence. Calcif Tissue Int 62:475-480
34. Canalis E (1993) Regulation of bone remodeling. In: Favus MJ (ed) Primer on the metabolic bone diseases and disorders on mineral metabolism, 2nd ed. American Society for Bone and Mineral Research, Chicago, pp 33-37
35. Ljunghall S, Joborn H, Benson L, Fellström B, Wide L, Åkerström G (1984) Effects of physical exercise on serum calcium and parathyroid hormone. Eur J Clin Invest 14:469-473
36. Ljunghall S, Joborn H, Rastad J, Åkerström G (1987) Plasma potassium and phosphate concentrations influenced by adrenaline infusion, β-blockade and physical exercise. Acta Med Scand 221:83-93