Effects of norepinephrine on the metabolism of fatty acids with different chain lengths in the perfused rat liver

Molecular and Cellular Biochemistry

Volumn 205, Issue 1-2, 2000, Pages 13-23

  Ishii Iwamoto, Emy L ^a   Ferrarese, Maria L L ^a   Constantin, Jorgete ^a   Salgueiro Pagadigorria, Clairce ^a   Bracht, Adelar ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Calcium; Fatty acids; Ketogenesis; Metabolism; Norepinephrine; Perfused rat liver

Indexed keywords

CALCIUM; LAURIC ACID; LONG CHAIN FATTY ACID; NORADRENALIN; OCTANOIC ACID; OLEIC ACID; PALMITIC ACID; STEARIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ESTERIFICATION; FATTY ACID METABOLISM; GLYCOGENOLYSIS; KETOGENESIS; LIVER; MALE; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; RAT; RESPIRATION CONTROL;

ANIMALIA;

EID: 0034002341     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1007094310429     Document Type: Article

References (44)

1. Steiner KE, Stevenson RW, Adkins-Marshall BA, Cherrington AD: The effects of epinephrine on ketogenesis in the dog after a prolonged fast. Metabolism 40: 1057-1062, 1991
2. Cryer PE: Adrenaline: A physiological metabolic regulatory hormone in humans? Int J Obes Relat Metab Disord S3: 43-46, 1993
3. Beylot M: Regulation of in vivo ketogenesis: Role of free fatty acids and control by epinephrine, thyroid hormones, insulin and glucagon. Diabetes Metab 22: 299-304, 1996
4. Krentz AJ, Freedman D, Greene R, McKinley M, Boyle PJ, Schade DS: Differential effects of physiological vs. pathophysiological plasma concentrations of epinephrine and norepinephrine on ketone body metabolism and hepatic portal blood flow in man. Metabolism 45: 1214-1220, 1996
5. Kosugi K, Harano Y, Nakano T, Suzuki M, Kashiwagi A, Shigeta Y: Mechanism of adrenergic stimulation of hepatic ketogenesis. Metabolism 32: 1081-1087, 1983
6. Oberhaensli RF, Schwendimann R, Keller U: Effect of norepinephrine on ketogenesis, fatty acid oxidation and esterification in isolated rat hepatocytes. Diabetes 34: 774-779, 1985
7. Stark B, Keller U: α-Adrenergic stimulation of ketogenesis and fatty acid oxidation is associated with inhibition of lipogenesis in rat hepatocytes. Experientia 43: 1104-1106, 1987
8. 2 in isolated rat hepatocytes. FEBS Lett 120: 80-84, 1980
9. Schofield PS, Kirk CJC, Sugden MC: Hormonal regulation of ketogenesis in hepatocytes from fed rats before and after glycogen depletion. Biochem Int 9: 611-620, 1984
10. 1-Adrenergic regulation of ketogenesis in isolated rat hepatocytes. Biochim Biophys Acta 1092: 94-100, 1991
11. 2 production following addition of octanoate and oleate in perfused rat liver. Bur J Biochem 141: 223-230, 1984
12. Scholz R, Bücher T: Hemoglobin-free perfusion of rat liver. In: B. Chance, R. Estabrook, J.R. Williamson (eds). Control of Energy Metabolism. Academic Press, New York, 1965, pp 393-414
13. Reinhart PH, Taylor WM, Bygrave FL: Calcium ion fluxes induced by the action of α-adrenergic agonists in perfused rat liver. Biochem J 208: 619-630, 1982
14. Williamson DH, Mellanby J: D-(-)3-Hydroxybutyrate. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1836-1839
15. Mellanby J, Williamson DH: Acetoacetate. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1840-1843
16. Bergmeyer HU, Bertit E: Glucose determination with glucose oxidase and peroxidase. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1205-1215
17. +. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1464-1468
18. Czok R, Lamprecht W: Pyruvate, phosphoenolpyruvate and glycerate-2-phosphate. In: H.U. Bergmeyer (ed). Methods of Enzymatic Analysis. Academic Press, New York, 1974, pp 1446-1451
19. Voss DO, Campello AP, Bacilla M: The respiratory chain and oxidative phosphorylation of rat brain mitochondria. Biochem Biophys Res Comm 4: 48-51, 1961
20. Woeltje KF, Kuwajima M, Foster DW, McGarry JD: Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. J Biol Chem 262: 9822-9827, 1987
21. Bremer J: The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA. Biochim Biophys Acta 665: 628-631, 1981
22. Bremer J, Norum KR: The mechanism of substrate inhibition of palmitoyl coenzyme A:carnitine palmitoyltransferase by palmitoyl coenzyme A. J Biol Chem 242: 1744-1748, 1967
23. Lowry OH, Rosebrough NJ, Farr AC, Randal RJ: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951
24. McGarry JD, Foster DW: The regulation of ketogenesis from oleic acid and the influence of antiketogenic agents. J Biol Chem 20: 6247-6253, 1971
25. McGarry JD, Weight PH, Foster DW: Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon. J Clin Invest 55: 11202-11209, 1975
26. McGarry JD, Foster DW: In support of the roles of malonyl-CoA and carnitine acyltransferases I in the regulation of hepatic fatty acid oxidation and ketogenesis. J Biol Chem 254: 8163-8168, 1979
27. Nomura T, Tachibana M, Nomura H, Chihara M, Hagino Y: Effects of phorbol esters, A23187 and vasopressin on oleate metabolism in isolated rat hepatocytes. Lipids 22: 474-479, 1987
28. Guzman M, Velasco G, Castro J: Effects of extracellular ATP on hepatic fatty acid metabolism. Am J Physiol 270: G701-G707, 1996
29. Soler-Argilaga C, Russell RL, Heimberg M: Enzymic aspects of the reduction of microsomal glycerolipid biosynthesis after perfusion of the liver with dibutyryl adenosine-3′,5′-monophosphate. Arch Biochem Biophys 190: 367-372, 1978
30. McGarry JD, Meier JK, Foster DW: The effects of starvation and refeeding on carbohydrate and lipid metabolism in vivo and in the perfused rat liver. J Biol Chem 248: 270-278, 1973
31. Bremer J, Wojtczac R: Factors controlling the rate of fatty acid β-oxidation in rat liver mitochondria. Biochim Biophys Acta 280: 515-530, 1972
32. Christiansen RZ, Bremer J: Fatty acid esterification and oxidation in liver cells isolated from fed, fasted and fasted-refed rats. In: H.D. Söling, C.D. Seufert (eds). Biochemical and Clinical Aspects of Ketone Body Metabolism. Georg Thieme Publishers, Stuttgart, 1978, pp 59-69
33. Mannaerts GP, Debeer L-J, de Schepper PJ: Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. J Biol Chem 11: 4585-4595, 1979
34. Skorkin C, Necochea C, Johow V, Soto U, Grau AM, Bremer J, Leighton F: Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes. Biochem J 281: 561-567, 1992
35. Mannaerts GP, Van Veldhoven PP: Peroxisomal beta-oxidation. Verh K Acad Geneeskd Belg 55: 45-78, 1993
36. Leighton F, Berseth S, Rortveir T, Christiansen EN, Bremer J: Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation. J Biol Chem 18: 10347-10350, 1989
37. Carpenter K, Pollitt RJ, Middelton B: Human liver long 3-hydroacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound beta-oxidation enzyme of mitochondria. Biochem Biophys Res Comm 183: 443-448, 1992
38. Uchida Y, Izai K, Orii T, Hashimoto T: Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. J Biol Chem 267: 1034-1041, 1991
39. Jackson S, Schaefer J, Middelton B, Turnbull DM: Characterization of a novel enzyme of human fatty acid beta-oxidation: A matrix-associated, mitochondrial 2-enoyl-CoA hydratase. Biochem Biophys Res Comm 214: 247-253, 1995
40. Dimsdale JE, Moss J: Plasma catecholamines in stress and exercise. JAMA 243: 340-342, 1980
41. Frayn KN, Little RA, Maycock PF, Stoner BB: The relationship of plasma catecholamines to acute metabolic and hormonal responses to injury in man. Circulatory Shock 16: 229-240, 1985
42. Krauns, P, Ruge W: Plasmakatecholamienspiegel bei Lebererkrankungen. Z Gastroenterologie 23: 64-73, 1985
43. Faraj BA, Caplan DB, Newman SL, Ahmann PA, Camp VM, Kutner M: Hypercatecholaminemia in Reye's syndrome. Pediatrics 73: 481-488, 1984
44. Iwai M, Jungermann K: Possible involvement of eicosanoids in the actions of sympathetic hepatic nerves on carbohydrate metabolism and hemodynamics in perfused rat liver. FEBS Lett 221: 155-160, 1987