Baclofen increases the soleus stretch reflex threshold in the early swing phase during walking in spastic multiple sclerosis patients

Multiple Sclerosis

Volumn 6, Issue 2, 2000, Pages 105-114

  Nielsen, Jørgen F ^a   Anderson, Jacob B ^b   Sinkjær, Thomas ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

Baclofen; Gain; Multiple sclerosis; Soleus stretch reflex; Spasticity; Threshold

Indexed keywords

BACLOFEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; LATENT PERIOD; MALE; MULTIPLE SCLEROSIS; MYOTATIC REFLEX; NEUROMODULATION; REFLEX; SOLEUS MUSCLE; SPASTICITY; WALKING; WALKING SPEED;

EID: 0034002011     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/135245850000600209     Document Type: Article

References (21)

1. Crenna P, Frigo C. (1987) Excitability of the soleus H reflex arc during walking and stepping in man. Exp Brain Res 66: 49-60.
2. Capaday C, Stein RB. (1986) Amplitude modulation of the soleus H-reflex in the human during walking and standing. J Neurosci 6: 1308-1313.
3. Sinkjaer T, Andersen JB, Larsen B. (1996) Soleus stretch reflex modulation during gait in healthy man. J Neurophysiol 76: 1112-1120.
4. Yang JF et al. (1991) H-reflex modulation during walking in spastic paretic subjects. Can J Neurol Sci 18: 443-452.
5. Sinkjaer T, Toft E, Hansen HJ. (1995) H-reflex modulation during gait in multiple sclerosis patients with spasticity. Acta Neurol Scand 91: 239-246.
6. Sinkjaer T, Andersen JB, Nielsen JF. (1996) Impaired stretch reflex and joint torque modulation during spastic gait in multiple sclerosis. J Neurol 243: 566-574.
7. Sachais BA, Logue JN, Carey MS. (1977) Baclofen, a new antispastic drug. A controlled, multicenter trial in patients with multiple sclerosis. Arch Neurol 34: 422-428.
8. Poser CM et al. (1983) New Diagnosis Criteria for Multiple Sclerosis: Guidelines for Research Protocols. Ann Neurol 13: 227-231.
9. Ashworth B. (1964) Preliminary trial of carisoprodol in multiple sclerosis. Practitioner 192: 540-542.
10. Andersen JB, Sinkjaer T. (1995) An acuator system for investigating electrophysiological and biomechanical features around the human ankle joint during gait. Trans Rehabil 3: 299-306.
11. Matthews PBC. (1959) A study of certain factors influencing the stretch reflex of the soleus muscle of the decerebrate cat. J Physiol 147: 547-564.
12. Feldman AG, Orlovsky GN. (1972) The influence of different descending systems on the tonic stretch reflex in the cat. Exp Neurol 37: 481-494.
13. Capaday C, Stein RB. (1987) Difference in the amplitude of the human soleus H reflex during walking and running. J Physiol 392: 513-522.
14. Burke D, Ashby P. (1972) Are spinal 'presynaptic' inhibitory mechanisms suppressed in spasticity. J Neurol Sci 15: 321-326.
15. Ashbv P, Mailis A, Hunter J. (1987) The evaluation of spasticity. Can J Neurol Sci 14: 497-500.
16. Edwards FR, Harrison PJ, Jack JJ, Kullmann DM. (1989) Reduction by baclofen of monosynaptic EPSPs in lumbosacral motoneurones of the anaesthetized cat. J Physiol 416: 539-556.
17. Peng YY, Frank E. (1989) Activation of GABAA receptors causes presynaptic and postsynaptic inhibition at synapses between muscle spindle afferents and motoneurons in the spinal cord of bullfrogs. J Neurosci 9: 1516-1522.
18. Nielsen JF, Sinkjaer T. (1996). A comparison of clinical and laboratory measures of spasticity. Multiple Sclerosis 1: 296-301.
19. Knutsson E, Richards C. (1979) Different types of disturbed motor control in gait of hemiparetic patients. Brain 102: 405-430.
20. Nielsen JF, Andersen JB, Sinkjaer T. Peripheral and central effect of baclofen on ankle joint stiffness in multiple sclerosis. Muscle & Nerve, in press.
21. Young RR. (1994) Spasticity: a review. Neurology 44: S12-S20.