Multiplex polymerase chain reaction-based analysis of T-cell receptor γ gene rearrangements for the determination of T-lymphocyte clonality

Environmental and Molecular Mutagenesis

Volumn 35, Issue 1, 2000, Pages 1-8

  Ma, Hongbao ^a   Smith, Darlene H ^a   Hsie, Abraham W ^a   Ward Jr , Jonathan B ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b 2102 Ewing Hall ^*  (United States)

Author keywords

Multiplex PCR; Mutational spectrum; Polyacrylamide gel electrophoresis (PAGE); T cell receptor gamma (TCR ) gene; T lymphocyte clonality

Indexed keywords

ENVIRONMENTAL MUTAGEN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ARTICLE; CELL MUTANT; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; GENE AMPLIFICATION; GENE MUTATION; GENE REARRANGEMENT; GENE STRUCTURE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTATION; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 0034000756     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(2000)35:1<1::AID-EM1>3.0.CO;2-C     Document Type: Article

References (25)

1. Albertini RJ, Hayes RB. 1997. Somatic cell mutations in cancer epidemiology. IARC Sci Publ 142:159-184.
2. Albertini RJ, Nicklas JA, O'Neill JP. 1993. Somatic cell gene mutations in humans: biomarkers for genotoxicity. Environ Health Perspect 101(Suppl 3):193-201.
3. Bottaro M, Berti E. Biondi A, Migone N. Crosti L. 1994. Heteroduplex analysis of T-cell receptor γ gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas. Blood 83:3271-3278.
4. Bourguin A, Tung R, Galili N, Sklar J. 1990. Rapid, nonradioactive detection of clonal T-cell receptor gene rearrangements in lymphoid neoplasms. Proc Natl Acad Sci USA 87:8536-8540.
5. Caggana M, Benjamin MB, Little JB, Liber HL, Kelsey KT. 1991. Single-strand conformation polymorphisms can be used to detect T cell receptor gene rearrangements: an application to the in vivo hprt mutation assay. Mutagenesis 6:375-379.
6. Cave H, Guidal C, Rohrlich P, Delfau MH, Broyart A, Lescoeur B, Rahimy C, Fenneteau O, Monplaisir N, d'Auriol L, Elion J, Vilmer E, Grandchamp B. 1994. Prospective monitoring and quantitation of residual blasts in childhood acute lymphoblastic leukemia by polymerase chain reaction study of δ and γ T-cell receptor genes Blood 83:1892-1902.
7. Clark LS, Nicklas JA. 1996. TCR β PCR from crude preparations for restriction digest or sequencing. Environ Mol Mutagen 27:34-38.
8. Curry J, Skandalis A, Holcroft J, de Boer J, Glickman BW. 1993. Coamplification of hprt cDNA and γ T-cell receptor sequences from 6-thioguanine resistant human T-lymphoctes. Mutat Res 288:269-275.
9. Davis MM, Bjorkman PJ. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395-402.
10. de Boer JG, Curry JD, Glickman BW. 1993. A fast and simple method to determine the clonal relationship among human T-cell lymphocytes. Mutat Res 288:173-180.
11. Grist SA, McCarron M, Kutlaca A, Turner DR, Morley AA. 1992. In vivo human somatic mutation: frequency and spectrum with age. Mutat Res 266:189-196.
12. Hakoda M, Hirai Y, Kyoizumi S, Akiyama M. 1989. Molecular analyses of in vivo hprt mutant T-cells from atomic bomb survivors. Environ Mol Mutagen 13:25-33.
13. Jamieson BD, Douek DC, Killian S, Hultin LE, Scripture-Adams DD, Giorgi JV, Marelli D, Koup RA, Zack JA. 1999. Generation of functional thymocytes in the human adult, Immunity 10:569-575.
14. Kronenberg M, Brines R. 1993. Developmental control of T cell antigen receptor gene rearrangement and expression. In Cooper EL, Nisbet-Brown E (eds): Developmental Immunology. Oxford: Oxford University Press, pp 153-173.
15. Lefranc MP, Rabbitts TH. 1990. Genetic organization of the human T-cell receptor γ and δ loci. Res Immunol 141:565-577.
16. Miller SA, Dykes DD, Polesky HF. 1988. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
17. Nicklas JA, O'Neill JP, Albertini RJ. 1986. Use of T-cell receptor gene probes to quantify the in vivo hprt mutations in human T-lymphocytes. Mutat Res 173:67-72.
18. Nicklas JA, O'Neill JP, Sullivan LM, Hunter TC, Allegretta M, Chastenay BF, Libbus BL, Albertini RJ. 1988. Molecular analyses of in vivo hypoxanthine-guanine phosphoribosyltransferase mutations in human T-lymphocytes. II. Demonstration of a clonal amplification of hprt mutant T-lymphocytes in vivo. Environ Mol Mutagen 12:271-284.
19. Nicklas JA, Hunter TC, O'Neill JP, Albertini RJ. 1989. Molecular analysis of in vivo hprt mutations in human T-lymphocytes. III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins. Mutat Res 215:147-160.
20. O'Neill JP, McGinniss MJ, Berman JK, Sullivan LM, Nicklas JA, Albertini RJ. 1987. Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans. Mutagenesis 2:87-94.
21. O'Neill JP, Nicklas JA, Hunter TC, Batson OB, Allegretta M, Falta MT, Branda RF, Albertini RJ. 1994. The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans. Mutat Res 313:215-225.
22. Strominger JL. 1989. Developmental biology of T cell receptors. Science 244:943-950.
23. Trainor KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA. 1991. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood 78:192-196.
24. Tycko B, Palmer JD, Link MP, Smith SD, Sklar J. 1989. Polymerase chain reaction amplification of rearranged antigen receptor genes using junctional-specific oligonucleotides: possible application for detection of minimal residual disease in acute lymphoblastic leukemia. Cancer Cell 7:47-52.
25. Yu YJ, Xu Z, Gibbs RA, Hsie AW. 1992. Polymerase chain reaction-based comprehensive procedure for the analysis of the mutation spectrum at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster cells. Environ Mol Mutagen 19:267-273.