Transdominant activity of human immunodeficiency virus type 1 Vpr with a mutation at residue R73

Journal of Virology

Volumn 74, Issue 10, 2000, Pages 4877-4881

  Sawaya, Bassel E ^a   Khalili, Kamel ^a   Gordon, Jennifer ^a   Srinivasan, Alagarsamy ^b   Richardson, Max ^a   Rappaport, Jay ^a   Amini, Shohreh ^a  

^a TEMPLE UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; VIRUS EXPRESSION; VIRUS MUTATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ARGININE; ASTROCYTES; CELL CYCLE; CELLS, CULTURED; GENE PRODUCTS, VPR; GENES, VPR; HIV-1; HUMANS; MUTATION; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRUS REPLICATION;

EID: 0034000259     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.10.4877-4881.2000     Document Type: Article

References (29)

1. Balliet, J. W., D. L. Kolson, G. Eiger, F. M. Kim, K. A. McGann, A. Srinivasan, and R. Collman. 1994. Distinct effects in primary macrophages and lymphocytes of human immunodeficiency virus type 1 accessory genes vpr, vpu and nef: mutational analysis of a primary HIV-1 isolate. Virology 200: 623-631.
2. Bogerd, H. P., R. A. Fridell, W. S. Blair, and B. R. Cullen. 1993. Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus. J. Virol. 67:5030-5034.
3. Bouhamdan, M., S. Benichou, F. Rey, J. M. Navarro, I. Agostini, B. Spire, J. Camonis, G. Slupphaug, R. Vigne, R. Benarous, and J. Sire. 1996. Human immunodeficiency virus type 1 Vpr protein binds to the uracin DNA glycosylase DNA repair enzyme. J. Virol. 70:697-704.
4. Cullen, B. R. 1998. HIV-1 auxiliary proteins: making connections in a dying cell. Cell 93:685-692.
5. Di Marzio, P., S. Choe, M. Ebright, R. Knoblauch, and N. Landau. 1995. Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. J. Virol. 69:7909-7916.
6. Emerman, M. 1996. HIV-1, Vpr and the cell cycle. Curr. Biol. 6:1096.
7. Felzien, L. K., C. Woffendin, M. O. Hottiger, R. A. Subbramanian, E. A. Cohen, and G. J. Nabel. 1998. HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. Proc. Natl. Acad. Sci. USA 95:5281-5286.
8. Freed, E. O., E. L. Delwart, G. L. Buchschacher, Jr., and A. T. Panganiban. 1992. A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity. Proc. Natl. Acad. Sci. USA 89:70-74.
9. Gallia, G. L., M. Safak, and K. Khalili. 1998. Interaction of single-stranded DNA binding protein, Purα, with human polyomavirus, JCV, early protein, T-antigen. J. Biol. Chem. 273:32662-32669.
10. Gragerov, A., T. Kino, G. Ilyina-Gragerova, G. P. Chrousos, and G. N. Pavlakis. 1998. HHR23A, the human homologue of the yeast repair protein RAD23, interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr. Virology 245:323-330.
11. Graham, F. L., and A. J. van der Eb. 1973. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
12. cdc2 activity. J. Virol. 69:6705-6711.
13. 2 + M phase of the cell cycle. J. Virol. 69:6304-6313.
14. Kino, T., A. Gragerov, J. B. Kopp, R. H. Stauber, G. N. Pavlakis, and G. P. Chrousos. 1999. The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor. J. Exp. Med. 189:51-62.
15. Luo, Z., D. J. Butcher, R. Murali, A. Srinivasan, and Z. Huang. 1998. Structural studies of synthetic peptide fragments derived from the HIV-1 Vpr protein. Biochem. Biophys. Res. Commun. 244:732-736.
16. Malim, M. H., W. W. Freimuth, J. Liu, T. J. Boyle, H. K. Lyerly, B. R. Cullen, and G. J. Nabel. 1992. Stable expression of transdominant Rev proteins in human T cells inhibits human immunodeficiency virus replication. J. Exp. Med. 176:1197-1201.
17. cdc2-cyclin B. J. Virol. 69:6859-6864.
18. Refaeli, Y., D. N. Levy, and D. B. Weiner. 1995. The glucocorticoid receptor type II complex is a target of the HIV-1 Vpr gene product. Proc. Natl. Acad. Sci. USA 92:3621-3625.
19. Sawaya, B. E., K. Khalili, W. E. Mercer, L. Denisova, and S. Amini. 1998. Cooperative actions of HIV-1 Vpr and p53 modulate viral gene transcription. J. Biol. Chem. 273:20052-20057.
20. Sawaya, B. E., K. Khalili, J. Rappaport, D. Serio, W. Chen, A. Srinivasan, and S. Amini. 1999. Suppression of HIV-1 transcription and replication by a Vpr mutant. Gene Ther. 6:947-950.
21. Schuler, W., K. Wecker, H. deRocquigny, Y. Baudat. J. Sire, and B. P. Roques. 1999. NMR structure of the (52-96) C-terminal domain of the HIV-1 regulatory protein Vpr: molecular insights into its biological functions. J. Mol. Biol. 285:2105-2117.
22. Shimura, M., Y. Zhou, Y. Asada, T. Yoshikawa, K. Helake, F. Takaku, and Y. Ishizaka. 1999. Inhibition of Vpr-induced cell cycle abnormality by quercetin: a novel strategy for searching compounds targeting Vpr. Biochem. Biophys. Res. Commun. 261:308-316.
23. Stark, L. A., and R. T. Hay. 1998. Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. J. Virol. 72:3037-3044.
24. Trono, D., M. B. Feinberg, and D. Baltimore. 1989. HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 59:113-120.
25. Wang, L., S. Mukherjee, F. Jia, O. Narayan, and L. J. Zhao. 1995. Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Spl and trans-activation of viral long terminal repeat. J. Biol. Chem. 270:25564-25569.
26. Wecker, K., and B. Rogues. 1999. NMR structure of the (1-51) N-terminal domain of the HIV-1 regulatory protein Vpr. Eur. J. Biochem. 266:359-369.
27. Westervelt, P., T. Henkel, D. B. Trowbidge, J. Orenstein, J. Heuser, H. E. Gendelman, and L. Ratner. 1992. Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants. J. Virol. 66:3925-3931.
28. Yao, X. J., R. A. Subbramanian, N. Rougeau, F. Boisvert, D. Bergeron, and E. A. Cohen. 1995. Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation. J. Virol. 69:7032-7044.
29. Zhao, L. J., L. Wang, S. Mukherjee, and O. Narayan. 1994. Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain. J. Biol. Chem. 269:32131-32137.