Enhancement of ursodeoxycholic acid bioavailability by cross-linked sodium carboxymethyl cellulose

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 4, 2000, Pages 383-388

  Scalia, Santo ^a,e   Giunchedi, Paolo ^b   Pazzi, Paolo ^c   Conte, Ubaldo ^d  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY HOSPITAL OF FERRARA   (Italy)

^d UNIVERSITY OF PAVIA   (Italy)

^e Dipartimento di Scienze Farmaceutiche   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYMETHYLCELLULOSE; URSODEOXYCHOLIC ACID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSS LINKING; CROSSOVER PROCEDURE; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; FEMALE; HUMAN; MALE; RANDOMIZED CONTROLLED TRIAL;

EID: 0033998782     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774129     Document Type: Article

References (17)

1. 1H-NMR spectrometry. Clin. Chim. Acta 228: 181-194
2. Crosignani, A., Setchell, K. D., Invernizzi, P., Larghi, A., Rodrigues, C., Podda, M. (1996) Clinical pharmacokinetics of therapeutic bile acids. Clin. Pharmacokinet. 30: 333-358
3. Giunchedi, P., Maggi, L., Conte, U., La Manna, A. (1993) Linear extended release of a water-insoluble drug, carbamazepine, from erodible matrices. Int. J. Pharm. 94: 15-22
4. Giunchedi, P., Scalia, S., Maggi, L., Conte, U. (1996) Ursodeoxycholic acid: improvement of dissolution behaviour and its HPLC determination. Int. J. Pharm. 130: 41-47
5. 2+ ions. J. Lipid Res. 33: 617-626
6. Panini, R., Vandelli, M. A., Forni, F., Pradelli, J. M., Salvioli, G. (1995) Improvement of ursodeoxycholic acid bioavailability by 2-hydroxypropyl-β-cyclodextrin complexation in healthy volunteers. Pharmacol. Res. 31: 205-209
7. Parquet, M., Metman, E. H., Raizman, A., Rambaud, J. C., Berthaux, N., Infante, R. (1985) Bioavailability, gastrointestinal transit, solubilization and fecal excretion of ursodeoxycholic acid in man. Eur. J. Clin. Invest. 15: 171-178
8. Roda, A., Roda, E., Festi, D., Colombo, C. (1988) Immunological methods for serum bile acid analysis. In: Setchell, K. D. R., Kritchevsky, D., Nair, P. P. (eds) The Bile Acids. Vol. 4, Plemum Press, New York, p. 270
9. Roda, A., Roda, E., Marchi, E., Simoni, P., Cerrè C., Pistillo, A., Polimeni, C. (1994) Improved intestinal absorption of an enteric-coated sodium ursodeoxycholate formulation. Pharm. Res. 11: 642-647
10. Scalia, S. (1989) Determination of bile acids in pharmaceutical dosage forms by HPLC. Anal. Lett. 22: 915-927
11. Scalia, S. (1995) Bile acid separation. J. Chromatogr. B 671: 299-317
12. Scalia, S., Cova, U., Fogagnolo, M., Landi S., Medici, A. (1994) Determination of free bile acids in raw materials and bulk products by HPLC and GC. Anal. Lett. 27: 1789-1804
13. Simoni, P., Cerrè, C., Cipolla, A., Polimeni, C., Pistillo, A., Ceschel, G., Roda, E., Roda, A. (1995) Bioavailability study of a new, sinking, enteric-coated ursodeoxycholic acid formulation. Pharmacol. Res. 31: 1-5
14. Stiehl, A., Raedsch, R., Rudolph, G. (1990) Acute effects of ursodeoxycholic acid and chenodeoxycholic acid on small intestine absorption of bile acids. Gastroenterology 98: 424-428
15. Vandelli, M. A., Salvioli, G., Mucci, A., Panini, R., Malmusi, L., Forni, F. (1995) 2-Hydroxypropyl-β-cyclodextrin complexation with ursodeoxycholic acid. Int. J. Pharm. 118: 77-83
16. Walker, S., Rudolph, G., Raedsch, R. (1992) Intestinal absorption of ursodeoxycholic acid in patients with extrahepatic biliary obstruction and bile drainage. Gastroenterology 102: 810-815
17. Ward, A., Brogden, R. N., Heel, R. C., Speight, T. M., Avery, G. S. (1984) Ursodeoxycholic acid: a review of its pharmacological properties and therapeutic efficacy. Drugs 27: 95-131