Structure-activity relationships of acyloxyamidine cytomegalovirus DNA polymerase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 3, 2000, Pages 601-615

  Tucker, John A ^a,b   Clayton, Terrance L ^a   Chidester, Connie G ^a   Schulz, Martin W ^a   Harrington, Leigh E ^a   Conrad, Steven J ^a   Yagi, Yoshihiko ^a   Oien, Nancee L ^a   Yurek, David ^a   Kuo, Ming Shang ^a  

^a PFIZER INC   (United States)

^b ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINE; DNA POLYMERASE; DNA POLYMERASE INHIBITOR; FUNCTIONAL GROUP; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CALCULATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; ENERGY; HUMAN CYTOMEGALOVIRUS; MASS SPECTROMETRY; MOLECULAR ORBITAL CALCULATION; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDINES; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; CYTOMEGALOVIRUS; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; HYDROCARBONS, AROMATIC; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SCINTILLATION COUNTING; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

CYTOMEGALOVIRUS;

EID: 0033998228     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00319-3     Document Type: Article

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