In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio- 1β-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 3, 2000, Pages 489-495

  Nagano, Rie ^a   Shibata, Kaneyoshi ^a   Adachi, Yuka ^a   Imamura, Hideaki ^a   Hashizume, Terutaka ^a   Morishima, Hajime ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1BETA METHYLCARBAPENEM; CARBAPENEM DERIVATIVE; IMIPENEM; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CARBAPENEMS; CARRIER PROTEINS; COAGULASE; COLONY COUNT, MICROBIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEXOSYLTRANSFERASES; HUMANS; IMIPENEM; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PEPTIDYL TRANSFERASES; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; THIENAMYCINS; VANCOMYCIN;

EID: 0033995358     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.3.489-495.2000     Document Type: Article

References (16)

1. IMP. Antimicrob. Agents Chemother. 39: 1612-1615.
2. Chambers, H. F. 1995. In vitro and in vivo antistaphylococcal activities of L-695,256, a carbapenem with high affinity for penicillin-binding protein PBP2a. Antimicrob. Agents Chemother. 39:462-466.
3. Duffull, S. B., and E. J. Begg. 1994. Vancomycin toxicity. What is the evidence for dose dependency? Adverse Drug Reactions Toxicol. Rev. 13:103-114.
4. Hanaki, H., H. Akagi, M. Yasui, T. Otani, A. Hyodo, and K. Hiramatsu. 1995. TOC-39, a novel parenteral broad-spectrum cepharosporin with excellent activity against methicillin-resistant Staphylococcus aureus, Antimicrob. Agents Chemother. 39:1120-1126.
5. Hiramatsu, K., H. Hanaki, T. Ino, K. Yabuta, T. Oguri, and F. C. Tenover. 1997. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J. Antimicrob. Chemother. 40:135-136.
6. Levine, D. P., B. S. Fromm, and B. R. Reddy. 1991. Slow response to vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis. Ann. Intern. Med. 115:674-680.
7. Lyon, B. R., and R. Skurray. 1987. Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiol. Rev. 51:88-134.
8. Nagano, R., K. Shibata, T. Naito, A. Fuse, K. Asano, T. Hashizume, and S. Nakagawa. 1997. Therapeutic efficacy of BO-3482, a novel dithiocarbamate carbapenem in mice infected with methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 41:2278-2281.
9. Nakagawa, S., T. Hashizume, K. Matsuda, M. Sanada, O. Okamoto, H. Fukatsu, and N. Tanaka. 1993. In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity. Antimicrob. Agents Chemother. 37:2756-2759.
10. Nakano, M., H. Kiyonaga, H. Imamura, A. Shimizu, H. Sato, Y. Sugimoto, S. Sakuraba, S. Nakagawa, H. Fukatsu, R. Ushijima, T. Hashizume, and R. Nagano. June 1999. World (PCT) patent WO9931106-A1.
11. Ohba, F., M. Nakamura-Kamijo, N. Watanabe, and K. Katsu. 1997. In vitro and in vivo activity of ER-35786, a new antipseudomonal carbapenem. Antimicrob. Agents Chemother. 41:298-307.
12. Saravolatz, D. L., D. J. Pohlod, and L. M. Arking. 1982. Community-acquired methicillin-resistant Staphylococcus aureus infections: a new source for nosocomial outbreaks. Ann. Intern. Med. 97:325-329.
13. Sumita, Y., H. Nouda, K. Kanazawa, and M. Fukasawa. 1995. Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 39:910-916.
14. Sunagawa, M., H. Matsumura, T. Inoue, M. Fukasawa, and M. Kato. 1990. A novel carbapenem antibiotic, SM-7338: structure-activity relationships. J. Antibiot. 43:519-532.
15. Utsui, Y., and T. Yokota. 1985. Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 28:397-403.
16. Watanabe, M., S. Iyobe, M. Inoue, and S. Mitsubishi. 1991. Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 35:147-151.