Antidepressant medications, mood and male fertility

Psychoneuroendocrinology

Volumn 25, Issue 1, 2000, Pages 37-51

  Hendrick, Victoria ^a   Gitlin, Michael ^a   Altshuler, Lori ^b   Korenman, Stanley ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Androgens; Antidepressants; Fertility; Men; Mood; Reproductive functioning

Indexed keywords

ANDROGEN; ANTIDEPRESSANT AGENT; CLOMIPRAMINE; DESIPRAMINE; FOLLITROPIN; GONADORELIN; IMIPRAMINE; LUTEINIZING HORMONE; NEFAZODONE; NEUROTRANSMITTER; NORTRIPTYLINE; TESTOSTERONE; VENLAFAXINE;

DEPRESSION; EMOTION; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; MALE FERTILITY; MENSTRUAL CYCLE; MOOD; PRIORITY JOURNAL; REPRODUCTION; REPRODUCTIVE TOXICITY; REVIEW; SEXUAL DYSFUNCTION; SPERMATOGENESIS; STRESS;

ANDROGENS; ANIMALS; ANTIDEPRESSIVE AGENTS; CLINICAL TRIALS; DEHYDROEPIANDROSTERONE; EMOTIONS; FEMALE; FERTILITY; HUMANS; INFERTILITY, MALE; MALE; MOOD DISORDERS; RATS; TESTOSTERONE;

EID: 0033992607     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(99)00038-4     Document Type: Review

References (94)

1. Altman N., Sachar E.J., Gruen P.H., Halpern F.S., Eto S. Reduced plasma LH concentration in postmenopausal depressed women. Psychosom. Med. 37:1975;274.
2. Amsterdam J.D., Winokur A., Lucki I., Snyder P. Neuroendocrine regulation in depressed postmenopausal women and healthy subjects. Acta Psychiatr. Scand. 67:1983;43-49.
3. Anand V.S. Clomipramine-induced galactorrhea and amenorrhea. Br. J. Psychiatry. 147:1985;87-88.
4. Anderson R.A., Bancroft J., Wu F.C.W. The effects of exogenous testosterone on sexuality and mood in normal men. J. Clin. Endocrinol. Metab. 75:1992;1503-1507.
5. Ashton A., Hamer R., Rosen R.C. Serotonin reuptake inhibitor-induced sexual dysfunction and its treatment: a large-scale retrospective study of 596 psychiatric outpatients. J. Sex Marital Ther. 23:1997;165-175.
6. Backstrom T., Carstenten H., Sodergad R. Concentration of estradiol, testosterone, and progesterone in cerebrospinal fluid compared to plasma unbound and total concentrations. J. Steroid Biochem. 7:1976;469-472.
7. Baker H.W.G. Male infertility. Endocrinol. Metab. Clin. North Am. 23:1994;783-793.
8. Barbarino A., de Mariuis C., Tofani A., Della Casa S., D'Amico C., Mancini A., Corsello S.M., Seinto R., Braini A. Corticotropin releasing hormone inhibition of gonadotropin release and the effect of opioid blockade. J. Clin. Endocrinol. Metab. 68:1989;523-528.
9. Berga S.L., Daniels T.L., Giles D.E. Women with functional hypothalamic amenorrhea but not other forms of anovulation display amplified cortisol concentrations. Fertil. Steril. 67:1997;1024-1030.
10. Berga S.L., Girton L.G. The psychoneuroendocrinology of functional hypothalamic amenorrhea. Psychiatr. Clin. North Am. 12:1989;105-116.
11. Bitran D., Hull E.M. Pharmacological analysis of male rat sexual behavior. Neurosci. Biobehav. Rev. 11:1987;365-389.
12. Bronzo M.R., Stahl S.M. Galactorrhea induced by sertraline. Am. J. Psychiatry. 150:1993;1269-1270.
13. Calogero A.E., Hall J., Fishel S., Green S., Hunter A., D'Agata R. Effects of gamma-aminobutyric acid on human sperm motility and hyperactivation. Mol. Hum. Reprod. 23:1996;733-738.
14. Carr D.W., Usselman M.C., Acott T.S. Effects of pH, lactate, and viscoelastic drag on sperm motility: a species comparison. Biol. Reprod. 33:1985;588-595.
15. Caspar R.C., Redmond D.E. Jr., Katz M.M., Schaffer C.B., Davis J.M., Koslow S.H. Somatic symptoms in primary affective disorder: presence and relationship to the classification of depression. Arch. Gen. Psychiatry. 42:1985;1098-1104.
16. Clayton A.H., Owens J.E., McGarvey E.L. Assessment of paroxetine induced sexual dysfunction using the Changes in Sexual Functioning Questionnaire. Psychopharmacol. Bull. 31:1995;397-413.
17. Clayton A.H., McGarvey E.L., Clavet G.J., Piazza L. Comparison of sexual functioning in clinical and nonclinical population using the Changes in Sexual Functioning Questionnaire (CSFQ). Psychopharmacol. Bull. 33:1997;747-753.
18. Clemens J.A., Roush M.E., Fuller R.W. Evidence that serotonin neurons stimulate secretion of prolactin releasing factor. Life Sci. 22:1978;2209-2213.
19. Cohen M.A., Davies P.H. Drug therapy and hyperprolactinemia. Adverse Drug React. Bull. 190:1998;723-726.
20. Cole E., Groom G., Link J. et al. Plasma prolactin concentrations in patients on clomipramine. Postgrad. Med. J. 52(suppl 3):1976;93-100.
21. Davidson J.M., Carmargo C.A, Smith E.R. Effects of androgen on sexual behavoir in hypogonadal men. J. Clin. Endocr. 48:1979;955-958.
22. Davies R.H., Harris B., Thomas D.R., Cook N., Read G., Riad-Fahmy D. Salivary testosterone levels and major depressive illness in men. Br. J. Psychiatry. 161:1992;629-632.
23. Demyttenaere K., Nijs P., Evers-Kiebooms G., Koninckz P.R. Coping and the ineffectiveness of coping influence the outcome of in vitro fertilization through stress responses. Psychoneuroendocrinology. 6:1992;655-665.
24. Demyttenaere K., Nijs P., Koninckx P.R., Steeno O., Evers-Kiebooms G. Anxiety and conception rates in donor insemination couples. J. Psychosom. Obstet. Gynecol. 8:1988;175-181.
25. Doerr P., Pirke K.M. Cortisol-induced suppression of plasma testosterone in normal adult males. J. Clin. Endocrinol. Metab. 43:1976;622-629.
26. Dubey A.K., Plant T.M. A suppression of gonadotropin secretion by cortisol in castrated male rhesus monkeys (Macaca mulatta) mediated by interruption of hypothalamic gonadotropin releasing hormone release. Biol. Reprod. 33:1985;423-431.
27. Facchinetti F., Volpe A., Matteo M.L., Genazzani A.R., Artini G.P. An increased vulnerability to stress is associated with a poor outcome of in vitro fertilization-embryo transfer treatment. Fertil. Steril. 67:1997;309-314.
28. Facchinetti F., Fava M., Fioroni L. et al. Stressful life events and affective disorders inhibit pulsatile LH secretion in hypothalamic amenorrhea. Psychoneuroendocrinology. 18:1993;397-404.
29. Fava G.A., Trombini G., Grandi S., Bernardi M. et al. Depression and anxiety associated with secondary amenorrhea. Psychosomatics. 25:1984;905-908.
30. Francis A., Williams R., Cole E. et al. The effect of clomipramine on prolactin levels - pilot studies. Postgrad. Med. J. 52(suppl3):1976;87-91.
31. Friedler G. Paternal exposures: impact on reproductive and developmental outcome. An overview. Pharmacol. Biochem. Behav. 55:1996;691-700.
32. Gitlin M.J. Sexual side effects of psychotropic medications. Psych. Clin. North Am. 4:1997;61-90.
33. Hamberger L., Janson P.O. Global importance of infertility and its treatment: role of fertility technologies. Int. J. Gynaecol. Obstet. 58:1997;149-158.
34. Hellhammer D.H., Hubert W., Freischem C.W., Nieschlag E. Male infertility: relationships among gonadotropins, sex steroids, seminal parameters and personality attitudes. Psychosom. Med. 1:1985;58-66.
35. Hess R.A., Bunick D., Lee K., Bahr J. et al. A role for oestrogens in the male reproductive system. Nature. 390:1997;509-512.
36. Jeffries J., Bezchlibnyk-Butler K., Remington G. Amenorrhea and galactorrhea associated with fluvoxamine in a loxapine-treated patient (ltr). J. Clin. Psychopharmacol. 12:1992;296-297.
37. Khuri R., Gehi M. Psychogenic amenorhea: an integrative review. Psychosomatics. 22:1981;883-899.
38. Kurland A.A., Pinto A., Destounis N., Babikow P.W. Effects of trimipramine (Surmontil) on spermatogenesis and mood in normal volunteers. Curr. Ther. Res. 12:1970;186.
39. Lapane K.L., Zierler S., Lasater T.M., Stein M. et al. Is a history of depressive symptoms associated with an increased risk of infertility in women? Psychosom. Med. 57:1995;509-513.
40. Laycock J.F., Wise P.H. Essential Endocrinology. 3rd edn:1996;Oxford University Press, Oxford.
41. Lesaca T.G. Sertraline and galactorrhea. J. Clin. Psychopharm. 16:1996;333-334.
42. Levin R.M., Amsterdam J.D., Winokur A., Weing A.J. Effects of psychotropic drugs on human sperm motility. Fertil. Steril. 36:1981;503-506.
43. Levitt A.J., Joffe R.T. Total and free testosterone in depressed men. Acta Psychiatr. Scand. 77:1988;346-0348.
44. Luisi M., Franchi F. Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients. J. Endocrinol. Invest. 3:1980;305-308.
45. MacLusky N.J., Naftolin F. Sexual differentiation of the central nervous system. Science. 211:1981;1294-1303.
46. Maier U., Koinig F. Andrological findings in young patients under long-term antidepressive therapy with clomipramine. Psychopharmacology. 116:1994;357-359.
47. Mason J.W., Giller E.L., Kosten T.R. Serum testosterone differences between patients with schizophrenia and those with affective disorder. Biol. Psychiatry. 23:1988;357-366.
48. McGahuey, C.A., Gelenberg, A.J., Laukes, C.A., Manber, P., McKnight, K.M., Moreno, F.A., Delgado, P.L., 1997. The Arizona Sexual Experience Scale: validity and reliability. New Research Program and Abstracts, 150th Annual Meeting of the American Psychiatric Association, Washington, DC, p. 116.
49. McNatty K., Sawers R., McNeilly A. A possible role for prolactin control of steroid secretion by the human graafian follicle. Nature. 250:1974;653.
50. Meller W.H., Zander K.M., Crosby R.D., Tagatz G.E. Luteinizing hormone pulse characteristics in depressed women. Am. J. Psychiatry. 154:1997;1454-1455.
51. Meltzer H., Bastani B., Jayathilake K., Maes M. Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder. Neuropsychopharmacology. 17:1997;1-11.
52. Millan M.G., Peglion J.-L., Lavielle G., Perrin-Monneyron S. 5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists. Eur. J. Pharmacol. 325:1997;9-12.
53. Mioduszewski R., Grandison L., Meites J. Stimulation of prolactin release in rats by GABA. Proc. Soc. Exp. Biol. Med. 151:1976;44-46.
54. Monteiro W.O., Norshirvani H.F., Marks I.M., Lelliott P.T. Anorgasmia from clomipramine in obsessive-compulsive disorder: a controlled trial. Br. J. Psychiatry. 151:1987;107-112.
55. Montejo-Gonzales A.L., Llorca G., Izquierdo J.A., Ledesma A., Bousono M., Calcedo A., Carrasco J.L., Ciudad J., Daniel E., De La Gandara J., Derecho J., Granco M., Gomez M.J., Macias J.A., Martin T., Perez V., Sanchez J.M., Sanchez J.M., Vicens E. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J. Sex Marital Ther. 23:1997;176-194.
56. Mooradian A.D., Morley J.E., Korenman S.G. Biological actions of androgens. Endocr. Rev. 8:1987;1-28.
57. Morales A., Johnston B., Heaton J.W., Clark A. Oral androgens in the treatment of hypogonadal impotent men. J. Urol. 152:1994;1115-1118.
58. Nilsson P.M., Moller L., Solstad K. Adverse effects of psychosocial stress on gonadal function and insulin levels in middle-aged males. J. Intern. Med. 237:1995;479-486.
59. Nofzinger E.A., Thawse M.E., Reyndolds C.F., Frank E., Jennings J.R., Garamoni G.L., Fasiczka A.L., Kupfer D.J. Sexual function in depressed men: assessment by self-report, behavioral, and nocturnal penile tumescence measured before and after treatment with cognitive behavior therapy. Arch. Gen. Psychiatry. 50:1993;24-30.
60. O'Carroll R., Bancroft J. Testosterone therapy for low sexual interest and erectile dysfunction in men: a controlled study. Br. J. Psychiatry. 145:1984;146-151.
61. Physician's Desk Reference, 1998. Medical Economics, Montvale, NJ.
62. Rabin D.S., Qadeer U., Steir V.E. A cost and outcome model of fertility treatment in a managed care environment. Fertil. Steril. 66:1996;896-903.
63. Ragni G.P., De Lauretis L., Bestetti O., Sghedoni D., Gambaro V. Gonadal function in male heroin and methadone addicts. Int. J. Androl. 11:1988;93-100.
64. Rivier C., Rivier J., Vale W. Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor. Science. 23:1986;607-609.
65. Rosen R.C., Lane R.M., Menza M. Effects of SSRIs on sexual function: a critical review. J. Clin. Psychopharmacol. 19:1999;67-85.
66. Rubin R.T. Sex steroid hormone dynamics in endogenous depression: a review. Intl. J. Mental Health. 10:1981;43-59.
67. Rubin R.T., Poland R.E., Lesser I.M. Neuroendocrine aspects of primary endogenous depression. VIII. Pituitary-gonadal axis activity in male patients and matched control subjects. Psychoneuroendocrinology. 14:1989;217-239.
68. Sachar E.J., Halpern F., Rosenfeld R.S., Gallagher T.F., Hellman L. Plasma and urinary testosterone levels in depressed men. Arch. Gen. Psychiatry. 28:1973;15-18.
69. Salmimies P., Kockott G., Pirke K.M. et al. Effects of testosterone replacement on sexual behavior in hypogonadal men. Arch. Sex. Behav. 11:1982;345-353.
70. Schenker J.G., Meirow D., Schenker E. Stress and human reproduction. Eur. J. Obstet. Gynecol. Reprod. Biol. 45:1992;1-8.
71. Schill, W.B., Przybilla, B., 1985. Zeitschrift fur Hautkrankheiten, 60, 1066-1076; 1079-1082.
72. Schlegel P.N., Girardi S.K. Clinical review 87: in vitro fertilization for male factor infertility. J. Clin. Endocrinol. Metab. 82:1997;709-716.
73. Schow, D.A., Redmon, B., Pryor, J.L., 1997. Male menopause. How to define it, how to treat it. Postgrad. Med. 62-64; 67-68; 71-74.
74. Schreiber C., Florin I., Rose W. Psychological correlates of functional secondary amenorrhea. Psychother. Psychosom. 39:1983;106-111.
75. Segraves R.T. Effects of psychotropic drugs on human erection and ejaculation. Arch. Gen. Psychiatry. 46:1989;275-284.
76. Segraves R.T. Antidepressant-induced sexual dysfunction. J. Clin. Psychiatry. 59(suppl 4):1998;48-54.
77. Skakkebaek N.E., Bancroft J., Davidson W. et al. Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double-blind controlled study. Clin. Endocrinol. 14:1981;49-61.
78. Sonntag A., Rothe B., Guldner J., Yassouridids A., Holsboer F., Steiger A. Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression. Depression. 4:1996;1-13.
79. Steiger A., von Bardeleben U., Widemann K., Holsboer F. Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission. J. Psychiatr. Res. 25:1991;169-177.
80. Stillman, 1986. Smoking and reproduction. Fertil. Steril. 46, 545-566.
81. Stoleru S., Teglas J.P., Fermanian J., Spira A. Psycological factors in the aetiology of infertility: a prospective cohort study. Hum. Reprod. 8:1993;1039-1046.
82. Su T.P., Pagliaro M., Schmidt P.J., Pickar D., Wolkowitz O., Rubinow D.R. Neuropsychiatric effects of anabolic steroids in male normal volunteers. J.Am. Med. Assoc. 269:1993;2760-2764.
83. Tanaka E., Baba N., Toshida K., Suzuki K. Evidence for 5HT2 receptor involvement in the stimulation of preovulatory LH and prolactin release and ovulation in normal cycling rats. Life Sci. 52:1993;669-676.
84. Taylor G., Bargett M., Csernansky J., Early T., Haller J., Scherrer J., Womack S. Male reproductive systems under chronic fluoxetine or trimipramine treatment. Physiol. Behav. 59:1996;479-485.
85. Thiering P., Beaurepaire J., Jones M., Saunders D., Tennant C. Mood state as a predictor of treatment outcome after in vitro fertilization/embryo transfer technology (IVF/ET). J Psychosom. Res. 37:1993;481-491.
86. Vogel W., Klaiber E.L., Broverman D.L. Roles of gonadal steroid hormones in psychiatric depression in men and women. Prog. Neuroopsychopharmacol. 2:1978;487-503.
87. Vogel W., Klaiber E.L., Broverman D.M. A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men. J. Clin. Psychiatry. 46:1985;6-8.
88. Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., Steiner B., Hull L., Callegari C., Swerdloff R.S. Testosterone replacement therapy improves mood in hypogonadal men - a clinical research center study. J. Clin. Endocrinol. Metab. 81:1996;3578-3583.
89. Weinberg J.B., Doty E., Bonaventura J., Haney A.F. Nitric oxide inhibition of human sperm motility. Fertil. Steril. 64:1995;408-413.
90. Wilson J., Foster D.W., Kronenberg H., Larsen P.R. Williams Textbook of Endocrinolgy. 9th edn:1998;Saunders, Philadelphia.
91. Wolf O.T., Neumann O., Hellhammer D.H., Geiben A.C., Strasburger C.J., Dressendrofer R.A., Pirke K., Kirschbaum C. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J. Clin. Endocrinol. Metab. 82:1997;2363-2367.
92. Wu F.C.N., Bancroft J., Davidson D.W. et al. The behaviourial effects of testosterone undecanoate in adult men with Klinefelter's syndrome: a controlled study. Clin. Endocrinol. 16:1982;489-497.
93. Yen S.S.C., Quicgley M.E., Reid R.L. et al. Neuroendocrinology of opioids, peptides and their role in the control of gonadotropin and prolactin secretion. Am. J. Obstet. Gynecol. 152:1985;485.
94. Yesavage J.A., Davidson J., Widrow L., Berger P. Plasma testosterone levels, depression, sexuality, and age. Biol. Psychiatry. 20:1985;199-228.