Titanocene(II)-promoted desulfurizative acylation of thioacetals with alkanenitriles

Tetrahedron Letters

Volumn 41, Issue 1, 2000, Pages 65-68

  Takeda, Takeshi ^a   Taguchi, Haruhiko ^a   Fujiwara, Tooru ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Acylation; Alkylation; Thioacetal; Titanium; Titanium compounds

Indexed keywords

ACETAL DERIVATIVE; BENZENE DERIVATIVE; KETONE; METHYL IODIDE; NITRILE; TITANOCENE;

ACYLATION; ALKYLATION; ARTICLE; REACTION ANALYSIS; SYNTHESIS;

EID: 0033992072     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)02001-8     Document Type: Article

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21. When the reaction of 1b with 4d was carried out in the presence of ethyl iodide (3.6 equiv.), the alkylated ketone, 3-ethyl-1-phenyloctan-4-one, was obtained in 18% yield along with 5a (46%). However, a similar reaction using butyl iodide produced no alkylation product.