Transport of model peptides across Ascaris suum cuticle

Molecular and Biochemical Parasitology

Volumn 105, Issue 1, 2000, Pages 39-49

  Sheehy, Barbara A ^a   Ho, Norman F H ^a   Burton, Philip S ^a   Day, Jeffrey S ^a   Geary, Timothy G ^a   Thompson, David P ^a  

^a PFIZER INC   (United States)

Author keywords

Ascaris suum; Cuticle; FMRFamide related peptides; Nematode; Peptides; Transport

Indexed keywords

PEPTIDE;

ARTICLE; ASCARIS SUUM; CUTICLE; HYDROGEN BOND; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SKIN ABSORPTION; SKIN PERMEABILITY; SUBCUTANEOUS TISSUE;

ANIMALS; ASCARIASIS; ASCARIS SUUM; BIOLOGICAL TRANSPORT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FMRFAMIDE; KINETICS; PEPTIDES; PERMEABILITY;

ASCARIS SUUM; HYPODERRIS; NEMATODA; VERTEBRATA;

EID: 0033991652     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00161-9     Document Type: Article

References (17)

1. Cowden C., Stretton A.O.W., Davis R.E. AF1, a sequenced bioactive neuropeptide isolated from the nematode Ascaris suum. Neuron. 2:1989;1465-1473.
2. Bowman J.W., Winterrowd C.A., Friedman A.R., Thompson D.P., Klein R.D., Davis J.P., Maule A.G., Blair K.L., Geary T.G. Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum. Journal of Neurophysiology. 74:1995;1880-1888.
3. Maule A.G., Geary T.G., Bowman J.W., Shaw C., Halton D.W., Thompson D.P. The pharmacology of nematode FMRFamide-related peptides. Parasitology Today. 12:1996;351-357.
4. 2) in the nematode, Ascaris suum. Molecular and Biochemical Parasitology. 75:1996;159-168.
5. Ho N.F.H., Geary T.G., Raub T.J., Barsuhn C.L., Thompson D.P. Biophysical transport properties of the cuticle of Ascaris suum. Molecular and Biochemical Parasitology. 41:1990;153-166.
6. Ho N.F.H., Geary T.G., Barsuhn C.L., Sims S.M., Thompson D.P. Mechanistic studies in the transcuticular delivery of antiparasitic drugs II: ex vivo/in vitro correlation of solute transport by Ascaris suum. Molecular and Biochemical Parasitology. 52:1992;1-14.
7. Ho N.F.H., Sims S.M., Vidmar T.J., Day J.S., Barsuhn C.L., Thomas E.M., Geary T.G., Thompson D.P. Theoretical perspectives on anthelmintic drug discovery: interplay of transport kinetics, physicochemical properties, and in vitro activity of anthelmintic drugs. Journal of Pharmaceutical Sciences. 83:1994;1052-1059.
8. Conradi R.A., Hilgers A.R., Ho N.F.H., Burton P.S. The influence of peptide structure on transport across caco-2 cells. Pharmaceutical Research. 8(12):1991;1453-1460.
9. Conradi R.A., Hilgers A.R., Ho N.F.H., Burton P.S. The influence of peptide structure on transport across caco-2 cells II: peptide bond modification which results in improved permeability. Pharmaceutical Research. 9(3):1992;435-439.
10. Burton P.S., Conradi R.A., Hilgers A.R., Ho N.F.H., Maggiora L.L. The relationship between peptide structure and transport across epithelial cell monolayers. Journal of Controlled Release. 19:1992;87-98.
11. Conradi R.A., Burton P.S., Borchardt R.T. Physicochemical and biological factors that influence a drug's cellular permeability by passive diffusion. Pliska V., Testa B., VandeWaterbeemd H., Mannhold R., Kubinyi H., Timmerman H. Lipophilicity in Drug Action and Toxicology. 1996;VCH Publishers, Weinheim.
12. Paterson A.D., Conradi R.A., Hilgers A.R., Vidmar T.J., Burton P.S. A non-aqueous partitioning systemfor predicting the oral absorption potential of peptides. Quantitative Structure-Activity Relationships. 13:1994;4-10.
13. Cowden C., Stretton A.O.W. AF2, an Ascaris neuropeptide: isolation, sequence and bioactivity. Peptides. 14:1993;423-430.
14. Thompson D.P., Ho N.F.H., Sims S.M., Geary T.G. Mechanistic approaches to quantitate anthelmintic absorption by gastrointestinal nematodes. Parasitology Today. 9:1993;31-35.
15. Sasaki T., Takagi M., Yaguchi T., Miyadoh S., Okada T., Koyama M. A new anthelmintic cyclodepsipeptide, PF1022A. Journal of Antibiotics. 45:1992;692-697.
16. Terada M., Ishih A., Tungthrongchitr M., Sano M., Shomura T. Effects of PF1022A on developing larvae of Angiostrongylus costaricensis in mice, with special reference to route, dose and formulation. Japanese Journal of Parasitology. 42:1993;199-210.
17. Conder G.A., Johnson S.S., Nowakowski D.S., Dutton F.E., Nelson S.J., Thomas E.M., Davis J.P., Thompson D.P. Anthelmintic profile of the cyclodepsipeptide PF1022A in in vitro and in vivo models. Journal of Antibiotics. 48:1995;820-823.