Mutant p53 protein, Bcl-2/Bax ratios and apoptosis in paediatric acute lymphoblastic leukaemia

Journal of Cancer Research and Clinical Oncology

Volumn 126, Issue 1, 2000, Pages 62-67

  Srinivas, G ^a   Panicker, K R ^a   Pillai, M R ^a   Kusumakumary, P ^a   Nair, M K ^a  

^a REGIONAL CANCER CENTRE   (India)

Author keywords

Bcl 2 Bax ratio; p53 and prognosis; Paediatric acute lymphoblastic leukaemia; Programmed cell death

Indexed keywords

ASPARAGINASE; CALCIUM; DAUNORUBICIN; METHOTREXATE; PHOSPHATIDYLSERINE; PREDNISONE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CHILD; CLINICAL ARTICLE; CORRELATION FUNCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; LYMPHADENOPATHY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL;

EID: 0033989764     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050010     Document Type: Article

References (36)

1. Bakhshi A, Jenson JP, Goldman P, Wright JJ, McBride OW, Epstein AL, Korsmeyer SJ (1985) Cloning the chromosomal breakpoint of t(14:18) human lymphocytes clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 41:889-906
2. Benito A, Lerga A, Silva M, Leon J, Fernandez LJL (1997) Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases (okadaic acid) is prevented by bcl-2 and bcl-xl. Leukemia 11:940-947
3. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposal for the classification of the acute leukemia's. French-American-British (FAB) Cooperative group. Br J Heamatol 33:451-458
4. x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608
5. Boyum HC (1968) Isolation of leucocytes from human blood. Further observations. Scand J Clin Lab Invest 21 [Suppl] 97: 31-50
6. Campana D, Coustan-Smith E, Manabe A, Buschie M, Raimondi SC, Behm FG, Ashmun R, Arico M, Biondi M, Pui CH (1993) Prolonged survival of B-lineage acute lymphoblastic leukaemia cells is accompanied by overexpression of bcl-2 protein. Blood 81:1025-1031
7. Collins MKL, Rivas AL (1993) The control of apoptosis in mammalian cells. Trends Biomed Sci 18:307-309
8. Cortes JE, Kantarjian HM (1995) Acute lymphoblastic leukemia: a comprehensive review with emphasis on biology and therapy. Cancer 76:2393-2417
9. Dowell SP, Hall PA (1994) The clinical relevance of the p53 tumor suppressor gene. Cytopathology 5:133-145
10. Findley HW, Gu L, Yeager AM, Zhou M (1997) Expression and regulation of bcl-2, bcl-Xl and bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood 89:2986-2993
11. Gala JL, Vermylen C, Comu G, Ferrant A, Michaux JL, Phillipe M, Martiat P (1994) High expression of bcl-2 is a rule in ALL, except Burkitt's subtype at presentation and is not correlated with prognosis. Ann Hematol 69:17-24
12. Ibrado AM, Huang Y, Fang G, Liu L, Bhalla K (1996) Overexpression of bcl-2 or bcl-Xl inhibits Ara-C induced CPP32/Yama proteases activity and apoptosis of human acute mylegenous leukemia HL-60 cells. Cancer Research 56:4743-4748
13. Imamura J, Miyoshi I, Koeffler P (1994) P53 in haematological malignancies. Blood 84:2412-2421
14. Kroemer G (1997) The proto oncogene bcl-2 and its role in regulating apoptosis. Nat Med 3:614-620
15. Leist M, Single B, Castoldi AF, Kuhnle S, Nicolera P (1997) Intracellular ATP concentration: a switch deciding between apoptosis and necrosis. J Exp Med 185:1481
16. Marks DI, Kurz BW, Link MP, Ng E, Shuster JJ, Lauer SJ, Brodsky I, Haines DS (1996) High incidence of potential p53 inactivation in poor outcome childhood lymphoblastic leukemia at diagnosis. Blood 87:1155-1161
17. McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnel TJ, Reed JC, Keating M (1996) Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of bcl-2 and bax. J Immunol 157:2624-2630
18. Miyasita, Reed (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bak gene. Cell 80:293-299
19. Oltwai ZN, Korsmeyer SJ (1994) Check points of dueling dimers foil death wishes. Cell 79:189-192
20. Oltwai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl2 heterodimerizes in vitro with a conserved homolog, bax, that accelerates programmed cell death. Cell 74:609-619
21. Pepper C, Hoy T, Bentley DP (1997) Bcl-2/bax ratios in chronic lymphocytic leukemia and their correlation with in vitro apoptosis and clinical resistance. Br J Cancer 76:935-938
22. Pillai MR, Kesari AL, Chellam VG, Madhavan JP, Nair P, Nair MK (1998) Spontaneous programmed cell death in infiltrating duct carcinoma: association with p53, bcl-2, hormone receptors and tumor proliferation. Pathol Res Pract 194:549-557
23. Ravi D, Nalinakumari KR, Rajaram RS, Nair MK, Pillai MR (1996) Expression of programmed cell death regulatory p53 and bcl-2 proteins in oral lesions. Cancer Lett 105:139-146
24. Ravi D, Ramadas K, Mathew BS, Nalinakumari KR, Nair MK, Pillai MR (1999) De novo programmed cell death in oral cancer. Histopathology 34:241-249
25. Reed JC (1997) Double identity for proteins of the bcl-2 family. Nature 387:773-776
26. Robertson LE, Plunkett W, McConnel K, Keating MJ, MCDonnel TJ (1996) Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia 10:456-459
27. Salomons GS, Brady HJM, Janssen MV, Van Den Berg JD, Hart AAM, Van Den Berg H, Behrendt H, Hahlen K, Smets LA (1997) The baxα:bcl-2 ratio modulates the response to dexamethasone in leukemic cells and is highly variable in childhood acute leukemia. Int J Cancer 71:959-965
28. Salomons GS, Buitenhus CKM, Munoz CM, Janssen MV, Behrendt H, Zsiros J, Smets LA (1998) Mutational analysis of bax and bcl-2 in childhood acute lymphoblastic leukemia. Int J Cancer 79:273-277
29. Smith EC, Kitanaka A, Pui CH, McNinch L, Evans WE, Raimondi SC, Bhem FG, Arico M, Campana D (1996) Clinical relevance of Bcl-2 overexpression in childhood acute lymphoblastic leukemia. Blood 87:1140-1146
30. Srinivas G, Kusumakumary P, Nair MK, Panicker KR, Pillai MR (1997) Tumor proliferative compartment, multidrug resistance gene product and apoptosis regulatory p53 and bcl-2 proteins in pediatric acute lymphoblastic leukemia. Onco Rep 4:1083-1087
31. Srinivas G, Kusumakumary P, Nair MK, Panicker KR, Pillai MR (1998) Bcl-2 protein and apoptosis in pediatric acute lymphoblastic leukemia. Int J Mol Medi 1:755-759
32. Thomas A, El Rouby S, Reed JC, Krajewski S, Silber R, Potmseil M, Newcomb EW (1996) Drug induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 12:1055-1062
33. Uckun FM, Yang Z, Sather H, Steinherz, Nachman, Bostrom, Crotty L, Sarquis M, Ek O, Zeren T, Tubergen D, Reaman G, Gaynon P (1997) Cellular expression of antiapoptotic bcl-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: A children's cancer group study. Blood 89:3769-3777
34. Wylie AA, Kerr JFR, Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306
35. Yang E, Korsmeyer SJ (1996) Molecular thanatopsis: a discourse on the bcl-2 family and cell death. Blood 88:386-401
36. Zhou M, Gu L, Yeager AM, Findley HW (1998) Sensitivity to Fas mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of bcl-2 expression. Leukemia 12:1756-1763