Non-invasive assessment of vascular function. Paradoxical vascular response to intravenous glucose in coronary heart disease

European Heart Journal

Volumn 21, Issue 1, 2000, Pages 39-44

  Leyva, Francisco ^a,b,d   Rauchhaus, M ^a   Anker, S D ^a   Proudler, A J ^b   Godsland, I F ^b   Stiefel, P ^c   Coats, A J S ^a   Poole Wilson, P A ^a   Stevenson, J C ^b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Atherosclerosis; Endothelium; Insulin

Indexed keywords

GLUCOSE; INSULIN;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL REACTIVITY; BOLUS INJECTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; FOREARM BLOOD FLOW; FUNCTIONAL ASSESSMENT; HUMAN; INSULIN RESPONSE; INTRAVENOUS GLUCOSE TOLERANCE TEST; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VEIN OCCLUSION PLETHYSMOGRAPHY;

ADULT; CORONARY DISEASE; ENDOTHELIUM, VASCULAR; FOREARM; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; REGIONAL BLOOD FLOW;

EID: 0033989229     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1053/euhj.1999.1695     Document Type: Article

References (32)

1. Healy B. Endothelial cell dysfunction: an emerging endocrinopathy linked to coronary disease. J Am Coll Cardiol 1990; 16: 357-8.
2. Sanz G, Castaner A, Betriu A et al. Determinants of prognosis in survivors of myocardial infarction. A prospective clinical and angiographic study. N Engl J Med 1982; 306: 1065-70.
3. El-Tamimi H, Mansour M, Wargovich TJ et al. Constrictor and dilator responses to intracoronary acetylcholine in adjacent segments of the same coronary artery in patients with coronary artery disease. Endothelial function revisited. Circulation 1994; 12: 56-62.
4. Reddy KG, Nair RN, Sheehan HM, Hodgson JMcB. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol 1994; 23: 833-43.
5. Ludmer PL, Selwyn AP, Shook TL et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046-51.
6. Folkow B, Grimby G, Thulesius O. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of peripheral resistance. Acta Physiol Scand 1958; 44: 255-72.
7. Nabel EL, Selwyn AP, Ganz P. Large coronary arteries in humans are responsive to changing blood flow: an endothelium-dependent mechanism that fails in patients with atherosclerosis. J Am Coll Cardiol 1990; 16: 349-56.
8. Wendelhag I, Gustavsson T, Suurkula M, Berglund G, Wikstrand U. Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of computerised analysing system. Clin Physiol 1991; 11: 565-77.
9. Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of the endothelium in the vasodilator response to increased blood flow. Hypertension 1996; 8: 37-44.
10. Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994; 267: E187-E202.
11. Vollenweider P, Tappy L, Randin D et al. Differential effects of hyperinsulinaemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest 1993; 92: 147-54.
12. Mäkimattila S, Virkamäki A, Malmström R et al. Insulin resistance in type 1 diabetes: a major role for reduced glucose extraction. J Clin Endocrinol Metab 1996; 81: 707-12.
13. McNulty PH, Pfau S. Insulin stimulates myocardial blood flow in humans by a direct effect within the coronary circulation. Circulation 1997; 96: 1-379.
14. Wu H-Y, Jeng Y-Y, Yue C-J, Chyu K-Y, Hsueh WA, Chan TM. Endothelial dependent vascular effects of insulin and insulin-like growth factor 1 in the perfused rat mesenteric artery and aortic ring. Diabetes 1994; 43: 1027-32.
15. Utrianen T, Mäkimattila S, Virkamäki A, Lindholm H, Sovijärvi A, Yri-Järvinen H. Physical fitness and endothelial function (nitric oxide synthesis) are independent determinants of insulin-stimulated blood flow in normal subjects. J Clin Endocrinol Metab 1996; 81: 4258-63.
16. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle stimulation of limb blood flow in normal subjects. J Clin Invest 1994; 94: 1172-9.
17. Scherrer YU, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994; 94: 2511-15.
18. Steinberg HO, Brechtel G, Johnson A, Baron AD. Insulin modulates endothelium derived relaxing factor/nitric oxide dependent vasodilation in skeletal muscle. Hypertension Dallas 1993; 22: 74-6.
19. Cardillo C, Kilcoyne CM, Quyyumi AA, Cannon RO, Panza JA. Nitric oxide-dependent vasodilator response to systemic but not to local hyperinsulinemia in the human forearm (Abstr). Circulation 1997; 96: 1-101.
20. Baron AD, Laakso M, Brechtel G, Hoit B, Edelman SV. Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. J Clin Endocrinol Metab 1990; 70: 1525-33.
21. Swan JW, Walton C, Godsland IF. Assessment of insulin sensitivity in man: a comparison of minimal model and euglycaemic clamp derived measures in health and heart failure. Clin Sci 1994; 86: 317-22.
22. Bennett WM, Connacher AA, Scrimgeour RT, Jung RT, Rennie MJ. Euglycemic hyperinsulinemia augments amni acid uptake by human leg tissues during hyperaminoacidemia. Am J Physiol (Endocrinol Metab 22) 1990; 259: E185-E194.
23. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest 1990; 85: 1844-52.
24. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 1172-9.
25. Vita JA, Treasure CB, Nabel EG et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990; 81: 491-7.
26. Panza JA, Quyyumy A, Brush JE, Epstein SE. Abnormal endothelium dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990; 323: 22-7.
27. McVeigh GE, Brennan GM, Johnston GD et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992; 35: 771-6.
28. Calver A, Collier J, Vallance P. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin dependent diabetes. J Clin Invest 1992; 90: 2548-54.
29. Schini VB, Catovsky S, Schray-Utz B, Busse R, Vanhoutte PM. Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells. Circ Res 1994; 74: 24-32.
30. Tesfamariam B, Brown ML, Deykin D, Cohen RA. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest 1990; 85: 929-32.
31. Bohlen HG, Lash JM. Topial hyperglycemia rapidly supresses EDRF-mediated vasodilation of normal rat arterioles. Am J Physiol 1993; 265: H219-225.
32. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy M-A, Simonson DC, Creager MA. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998; 97: 1695-1701.