Effect of UV-A light on the chaperone-like properties of young and old lens α-crystallin

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 1, 2000, Pages 191-198

  Weinreb, Orly ^c   Van Boekel, Martinus Adrianus Maria ^c   Dovrat, Ahuva ^a   Bloemendal, Hans ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; CHAPERONE; MESSENGER RNA; PROTEIN SUBUNIT; TRYPTOPHAN;

ADOLESCENT; AGED; ANIMAL TISSUE; ARTICLE; CATARACT; CATTLE; CONTROLLED STUDY; FLUORESCENCE; GEL FILTRATION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; LENS; NONHUMAN; PRIORITY JOURNAL; TWO DIMENSIONAL GEL ELECTROPHORESIS; ULTRAVIOLET A RADIATION;

AGING; ANIMALS; CATTLE; CHAPERONINS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; CRYSTALLINS; DEAMINATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; LENS, CRYSTALLINE; ORGAN CULTURE TECHNIQUES; RNA, MESSENGER; ULTRAVIOLET RAYS;

EID: 0033988045     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Bloemendal H. The vertebrate eye lens. Science. 1977;197:127-138.
2. Bhat SD, Nagineni CN. AlphaB subunit of lens-specific protein alpha crystallin is present in other ocular and non-ocular tissues. Biochem Biophys Res. Commun. 1989;158:319-325.
3. Groenen PJA, Merck KB, de Jong WW, Bloemendal H. Structure and modification of the junior chaperone α-crystallin from lens transparency to molecular pathology. Eur J Biochem. 1994;225: 1-19.
4. de Jong WW, Leunissen JAM, Voorter CEM. Evolution of the α-crystallin/small heat-shock protein family. Mol Biol Evol. 1993;10:103-126.
5. Horwitz J, Huang QL, Ding L, Bova MP. Lens α-crystallin: chaperone-like properties. Methods Enzymol. 1998;290:365-383.
6. Taylor HR. Ultraviolet radiation and the eye lens: an epidemiologic study. Trans Am Ophthalmol Soc. 1989;87:802-853.
7. Stevens MA, Bergmanson JPG. Dose sunlight cause premature aging of the crystalline lens? J Am Opt Assoc. 1989;60:660-663.
8. Young RW. Sunlight and age-related eye diseases. J Natl Med Assoc. 1992;84:353-358.
9. West SK. Daylight, diet, and age-related cataract. Optom Vis Sci. 1993;70:869-872.
10. Takemoto LJ, Boyle D. The possible role of α-crystallin in human senile cataractogenesis. Int J Biol Macromol. 1998;22:331-337.
11. Schauerte JA, Gafni A. Photodegradation of tryptophan residues and attenuation of molecular chaperone activity in α-crystallin are correlated. Biochem Biophys Res Commun. 1995;212:900-905.
12. Borkman RF, McLaughlin J. The molecular chaperone function of α-crystallin is impaired by UV photolysis. Photochem Photobiol. 1995;62:1046-1051.
13. Ellozy AR, Ceger P, Wang RH, Dillon J. Effect of the UV modification of α-crystallin on its ability to suppress nonspecific aggregation Photochem Photobiol. 1996;64:344-348.
14. Lee JS, Liao JH, Wu SH, Chiou SH. α-Crystallin acting as a molecular chaperone against photodamage by UV irradiation. J Protein Chem. 1997;16:283-289.
15. Dovrat A, Weinreb O. Recovery of lens optics and epithelial enzymes after ultraviolet A radiation. Invest Ophthalmol Vis Sci. 1995;36:2417-2424.
16. Weinreb O, Dovrat A. Transglutaminase involvement in UV-A damage to the eye lens. Exp Eye Res. 1996;63:591-597.
17. Weinreb O, Dovrat A. Effect of UV-A radiation on lens epithelial Na,K-ATPase in organ culture. Invest Ophthalmol Vis Sci. 1999; 40:1616-1620.
18. Sivak JG, Yoshimura M, Weerheim J, Dovrat A. Effect of hydrogen peroxide, DL-propranolol and prednisone on the bovine lens optical function in culture. Invest Ophthalmol Vis Sci. 1990;31:954-963.
19. Slingsby C, Bateman O A. Rapid separation of bovine β-crystallin subunits βB1, βB2, βB3, βA3 and βA4. Exp Eye Res. 1991;51:21-26.
20. de Jong WW, van Kleef FSM, Bloemendal H. Intracellular carboxyl-terminal degradation of the αA chain of α-crystallin. Eur J Biochem. 1974;48:271-276.
21. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
22. O'Farrell PH. High resolution two-dimensional electrophoresis of protein. J Biol Chem. 1975;250:4007-4021.
23. Bloemendal H, Van de gaer K, Benedetti EL, Dunia I, Steely HT. Towards a human crystallin map: two-dimensional gel electrophoresis and computer analysis of water-soluble crystallin from normal and cataractous human lenses. Ophthalmic Res. 1996;29:177-190.
24. Horwitz J. α-Crystallin can function as a molecular chaperone. Proc Natl Acad Sci USA. 1992;89:10449-10453.
25. Church WH, Gilbert W. Genomic sequencing. Proc Natl Acad Sci USA. 1984;81:1991-1995.
26. Voor CEM, Roersma ES, Bloemendal H, de Jong WW. Age-dependent deamidation of chicken αA-crystallin. FEBS Lett. 1987;221: 249-252.
27. Horwitz J, Emmons T, Takemoto L. The ability of lens alpha crystallin to protect heat-induced aggregation is age-dependent. Curr Eye Res. 1992;11:817-822.
28. van Boekel MAM, Hoogakker SEA, de Jong WW. The influence of some post-translational modifications on the chaperone-like activity of α-crystallin. Ophthalmic Res. 1996;28:32-38.
29. Fuji N, Momose Y, Ishibashi Y, Uemura T, Takita M, Takehana M. Specific racemization and isomerization of the aspartyl residue of αA-crystallin due to UV-B irradiation. Exp Eye Res. 1997;65:99-104.
30. Finley EL, Busman M, Dillon J, Crouch RK, Schey KL. Identification of photooxidation sites in bovine α-crystallin. Pbotochem Photobiol. 1997;66:635-641.