Pseudorabies virus expressing bovine herpesvirus 1 glycoprotein B exhibits altered neurotropism and increased neurovirulence

Journal of Virology

Volumn 74, Issue 2, 2000, Pages 817-827

  Gerdts, Volker ^a,c   Beyer, Jörg ^a   Lomniczi, Béla ^b   Mettenleiter, Thomas C ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOVINE HERPES VIRUS; CONTROLLED STUDY; DELETION MUTANT; NEUROTROPISM; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDORABIES HERPETOVIRUS; SEQUENCE HOMOLOGY; SWINE; VERO CELL; VIRUS CELL INTERACTION; VIRUS ENCEPHALITIS; VIRUS GENOME; VIRUS VIRULENCE;

ANIMALS; ANTIGENS, VIRAL; CATTLE; CELL LINE; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; CRYOULTRAMICROTOMY; FLUORESCENT ANTIBODY TECHNIQUE; HERPESVIRUS 1, BOVINE; HERPESVIRUS 1, SUID; PSEUDORABIES; SWINE; VIRAL ENVELOPE PROTEINS; VIRULENCE;

EID: 0033987569     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.2.817-827.2000     Document Type: Article

References (49)

1. Babic, N., T. C. Mettenleiter, A. Flamand, and G. Ugolini. 1993. Role of essential glycoproteins gII and gp50 in transneuronal transfer of pseudorabies virus from the hypoglossal nerve of mice. J. Virol. 67:4421-4426.
2. Babic, N., T. C. Mettenleiter, G. Ugolini, A. Flamand, and P. Coulon. 1994. Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation. Virology 204:616-625.
3. Balasch, M., J. Pujols, J. Plana-Duran, and M. Pumarola. 1998. Study of the persistence of Aujeszky's disease (pseudorabies) virus in peripheral blood mononuclear cells and tissues of experimentally infected pigs. Vet. Microbiol. 62:171-183.
4. Card, J. P., L. Rinaman, R. B. Lynn, B. H. Lee, R. P. Meade, R. R. Miselis, and L. W. Enquist. 1993. Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport and pathogenesis. J. Neurosci. 13:2515-2539.
5. Card, J. P., and L. W. Enquist. 1995. Neurovirulence of pseudorabies virus. Crit. Rev. Neurobiol. 9:137-162.
6. Card, J. P., P. Leavitt, and L. W. Enquist. 1998. Different patterns of neuronal infection after intracerebral injection of two strains of pseudorabies virus. J. Virol. 72:4434-4441.
7. Engel, J. P., E. P. Boyer, and J. L. Goodman. 1993. Two novel single amino acid syncytial mutations in the carboxy terminus of glycoprotein B of herpes simplex virus type 1 confer a unique pathogenic phenotype. Virology 192: 112-120.
8. Enquist, L. W. 1994. Infection of the mammalian nervous system by pseudorabies virus (PRV). Semin. Virol. 5:221-231.
9. Enquist, L. W., P. J. Husak, B. W. Banfield, and G. A. Smith. 1998. Infection and spread of alphaherpesviruses in the nervous system. Adv. Virus Res. 51:237-347.
10. Gage, P. J., M. Levine, and J. C. Glorioso. 1993. Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein gB. J. Virol. 67:2191-2201.
11. Gerdts, V., A. Jöns, B. Makoschey, N. Visser, and T. C. Mettenleiter. 1997. Protection of pigs against Aujeszky's disease by DNA vaccination. J. Gen. Virol. 78:2139-2146.
12. Gerdts, V., A. Jöns, and T. C. Mettenleiter. 1999. Potency of an experimental DNA vaccine against Aujeszky's disease in pigs. Vet. Microbiol. 66:1-13.
13. Gibbs, E., and M. Rweyemamu. 1977. Bovine herpesviruses. Part I. Bovine herpesvirus 1. Vet. Bull. 47:317-343.
14. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus. Virology 52:456-467.
15. Kaplan, A. S., and A. E. Vatter. 1959. A comparison of herpes simplex and pseudorabies viruses. Virology 7:394-407.
16. Kimman, T. G., N. de Wind, N. Oie-Lie, J. M. A. Pol, A. J. M. Berns, and A. L. J. Gielkens. 1992. Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis, and immunogenicity. J. Gen. Virol. 73:243-251.
17. Klupp, B. G., A. Karger, and T. C. Mettenleiter. 1997. Bovine herpesvirus 1 glycoprotein gB does not productively interact with cell surface heparan sulfate in a pseudorabies virion background. J. Virol. 71:4838-4841.
18. Knapp, A. C., P. J. Hussak, and L. W. Enquist. 1998. The gE and gI homologs from two alphaherpesviruses have conserved and divergent neuroinvasive properties. J. Virol. 71:5820-5827.
19. Kopp, A., and T. C. Mettenleiter. 1992. Stable rescue of a glycoprotein gII deletion mutant of pseudorabies virus by glycoprotein gI of bovine herpesvirus 1. J. Virol. 66:2754-2762.
20. Kritas, S. K., M. B. Pensaert, and T. C. Mettenleiter. 1994 Invasion and spread of single glycoprotein deleted mutants of Aujeszky's disease virus (ADV) in the trigeminal nervous pathway of pigs after intranasal inoculation. Vet. Microbiol. 40:323-334.
21. Kritas, S. K., M. B. Pensaert, and T. C. Mettenleiter. 1994. Role of gI, gp63 and gIII in the invasion and spread of Aujeszky's disease virus (ADV) in the olfactory nervous pathway of pigs. J. Gen. Virol. 75:2319-2327.
22. Li, Y., S. van Drunen Liltel-van den Hurk, L. A. Babiuk, and X. Liang. 1995. Characterization of cell-binding properties of bovine herpesvirus 1 glycoproteins B, C, and D: identification of a dual cell-binding function of gB. J. Virol. 69:4758-4768.
23. Lukács, N., H.-J. Thiel, T. C. Mettenleiter, and H.-J. Rziha. 1985. Demonstration of three major species of pseudorabies virus glycoproteins and identification of a disulfide-linked glycoprotein complex. J. Virol. 53:155-173.
24. Mettenleiter, T. C. 1994. Initiation and spread of α-herpesvirus infections. Trends Microbiol. 2:2-4.
25. Mettenleiter, T. C. 1994. Pseudorabies (Aujeszky's disease) virus: state of the art. Acta Vet. Hung. 42:153-177.
26. Mettenleiter, T. C. 1995. Molecular properties of alphaherpesviruses used in transneuronal pathway tracing, p. 367-393. In M. G. Kaplitt and A. D. Loewy (ed.), Viral vectors. Academic Press, San Diego, Calif.
27. Mettenleiter, T. C., and P. G. Spear. 1994. Glycoprotein gB (gII) of pseudorabies virus can functionally substitute for glycoprotein gB in herpes simplex virus type 1. J. Virol. 68:500-504.
28. Mettenleiter, T. C., L. Zsak, A. Kaplan, T. Ben-Porat, and B. Lomniczi. 1987. Role of a structural glycoprotein of pseudorahies in virus virulence. J. Virol. 61:4030-4032.
29. Meyer-Koenig, U., C. Vogelberg, A. Bongarts, D. Kampa, R. Delbruck, G. Wolff-Vorbeck, G. Kirste, M. Haberland, F. T. Hufert, and D. von Laer. 1998. Glycoprotein gB genotype correlates with cell tropism in vivo of human cytomegalovirus infection. J. Med. Virol. 55:75-81.
30. Mulder, W., L. Jacobs, J. Priem, G. Kok, F. Wagenaar, T. Kimman, and J. Pol. 1994. Glycoprotein E-negative pseudorahies virus has a reduced capability to infect second and third order neurons of the olfactory and trigeminal routes in the porcine central nervous system. J. Gen. Virol. 75:3095-3106.
31. Neubauer, A., M. Beer, C. Brandmuller, O. R. Kaaden, and N. Osterrieder. 1997. Equine herpesvirus 1 mutants devoid of glycoprotein B or M are apathogenic for mice but induce protection against challenge infection. Virology 239:36-45.
32. Nickel, R., A. Schummer, and E. Seiferle. 1984. Lehrbuch der Anatomie der Haustiere, Band IV: Nervensystem, Sinnesorgane, Endokrine Drüsen; Gehirnnerven p. 250-290. Geruchsorgan p. 344-346. Paul Parey, Berlin, Germany.
33. Peeters, B., N. de Wind, M. Hooisma, F. Wagenaar, A. Gielkens, and R. Moormann. 1992. Pseudorabies virus envelope glycoproteins gp50 and gII are essential for virus penetration, but only gII is involved in membrane fusion. J. Virol. 66:894-905.
34. Pensaert, M., and J. Kluge. 1989. Pseudorabies virus (Aujeszky's disease), p. 39-64. In M. Pensaert (ed.), Virus infections of porcines. Elsevier Science Publishers, Amsterdam, The Netherlands.
35. Pereira, L. 1994. Function of glyoprotein B homologues of the family herpesviridae. Infect. Agents Dis. 3:9-28.
36. Rassnick, S., L. W. Enquist, A. F. Sved, and P. Card. 1998. Pseudorabies virus-induced leukocyte trafficking into the rat central nervous system. J. Virol. 72:9181-9191.
37. Rauh, I., F. Weiland, F. Fehler, G. M. Keil, and T. C. Mettenleiter. 1991. Pseudorabies virus mutants lacking the essential glycoprotein gII can be complemented by glycoprotein gI of bovine herpesvirus 1. J. Virol. 65:621-631.
38. Rinaman, L., J. P. Card, and L. W. Enquist 1993. Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus. J. Neurosci. 13:685-702.
39. Roizman, B., R. C. Desrosiers, B. Fleckenstein, C. Lopez, A. C. Minson, and M. J. Studdert. 1992. The family of herpesviridae: an update. Arch. Virol. 123:425-449.
40. Rziha, H.-J., T. C. Mettenleiter, V. Ohlinger, and G. Wittmann. 1986. Herpesvirus (pseudorabies virus) latency in swine: occurrence and physical state of viral DNA in neural tissues. Virology 155:600-613.
41. Sams, J. M., A. S. Jansen, T. C. Mettenleiter, and A. D. Loewy. 1995. Pseudorabies virus mutants as transneuronal markers. Brain Res, 687:182-190.
42. Sivadon, V., P. Lebon, and F. Rozenberg. 1998. Variations of HSV-1 glycoprotein B in human herpes simplex encephalitis. J. Neurovirol. 4:106-114.
43. Spear, P. 1993. Entry of alphaherpesviruses into cells. Semin. Virol. 4:167-180.
44. Tirabassi, R. S., R. A. Townley, M. G. Eldrige, and L. W. Enquist. 1997. Characterization of pseudorabies virus mutants expressing carboxy-terminal truncations of gE: evidence for envelope incorporation, virulence, and neurotropism domains. J. Virol. 71:6455-6464.
45. Tugizov, S., Y. Wang, I. Qadri, D. Navarro, E. Maidji, and L. Pereira. 1995. Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation. Virology 209:580-591.
46. Whealy, M. E., J. P. Card, A. K. Robbins, J. R. Dublin, H. J. Rziha, and L. W. Enquist. 1993. Specific pseudorabies infection of the rat visual system requires both gI and gp63 glycoproteins. J. Virol. 67:3786-3797.
47. Wheater, P. R., H. G. Hurkitt, and V. G. Daniels. 1987. Functional histology, a text and colour atlas, 2nd ed., revised by P. R. Wheater and H. G. Burkitt. Churchill Livingstone, Edinburgh, Scotland.
48. Yuhasz, S. A., and J. G. Stevens. 1993. Glycoprotein gB is a specific determinant of herpes simplex virus type 1 neuroinvasiveness. J. Virol. 67:5948-5954.
49. Zuckermann, F., T. C. Mettenleiter, C. Schreurs, N. Sugg, and T. Ben-Porat. 1988. Complex between glycoproteins gI and gp63 of pseudorabies virus: its effect on virus replication. J. Virol. 62:4622-4626.