Susceptibilities of Neisseria gonorrhoeae isolates containing amino acid substitutions in GyrA, with or without substitutions in ParC, to newer fluoroquinolones and other antibiotics

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 1, 2000, Pages 192-195

  Tanaka, Masatoshi ^a   Nakayama, Hiroshi ^b   Haraoka, Masashi ^a   Saika, Takeshi ^c   Kobayashi, Intetsu ^c   Naito, Seiji ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Nakayama Urologic Clinic   (Japan)

^c LSI MEDIENCE CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 7 (7 AMINO 5 AZASPIRO[2.4]HEPT 5 YL) 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHYL 4 OXO 3 QUINOLINECARBOXYLIC ACID; AZITHROMYCIN; CEFTRIAXONE; CIPROFLOXACIN; GATIFLOXACIN; GREPAFLOXACIN; IMIPENEM; LEVOFLOXACIN; MOXIFLOXACIN; NORFLOXACIN; PAZUFLOXACIN; PENICILLIN G; PRULIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SITAFLOXACIN; SPARFLOXACIN; SPECTINOMYCIN; TETRACYCLINE DERIVATIVE; TROVAFLOXACIN;

AMINO ACID SUBSTITUTION; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIUM ISOLATION; DNA SEQUENCE; DRUG EFFECT; DRUG EFFICACY; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NEISSERIA GONORRHOEAE; PRIORITY JOURNAL; STRAIN DIFFERENCE;

EID: 0033986939     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.1.192-195.2000     Document Type: Article

References (11)

1. Belland, R. J., S. G. Morrison, C. A. Ison, and W. M. Huang. 1994. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol. Microbiol. 14:371-380.
2. Deguchi, T., M. Yasuda, M. Nakano, S. Ozeki, T. Ezaki, I. Saito, and Y. Kawada. 1996. Ouinolone-resistant Neisseria gonorrhoeae correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob. Agents Chemother. 40:1020-1023.
3. Fox, K. K., J. S. Knapp, K. K. Holmes, E. W. Hook III, F. N. Judson, S. E. Thompson, J. A. Washington, and W. L. Whittington. 1997. Antimicrobial resistance in Neisseria gonorrhoeae in the United States, 1988-1994: the emergence of decreased susceptibility to the fluoroquinolones. J. Infect. Dis. 175:1396-1403.
4. Gill, M. J., S. Simjee, K. Al-Hattawi, B. D. Robertson, C. S. F. Easmon, and C. A. Ison. 1998. Gonococcal resistance to β-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus. Antimicrob. Agents Chemother. 42:2799-2803.
5. Hagman, K. E., and W. M. Shafer. 1995. Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae. J. Bacteriol. 177:4162-4165.
6. Ison, C. A., J. A. R. Dillon, and J. W. Tapsall. 1998. The epidemiology of global antibiotic resistance among Neisseria gonorrhoeae and Haemophilus ducreyi. Lancet 351(Suppl. III):8-11.
7. Nakashima, M., T. Uematsu, K. Kosuge, K. Umemura, H. Hakusui, and M. Tanaka, 1995. Pharmacokinetics and tolerance of DU-6859a, a new fluoroquinolone, after single and multiple oral doses in healthy volunteers. Antimicrob. Agents Chemother. 39:170-174.
8. National Comittee for Clinical Laboratory Standards. 1998. Performance standards for antimicrobial susceptibility testing. Eighth informational supplement. Document M100-S8, vol. 18, no. 1. National Comittee for Clinical Laboratory Standards, Wayne, Pa.
9. Tanaka, M., T. Matsumoto, M. Sakumoto, K. Takahashi, T. Saika, I. Kobayashi, J. Kumazawa, and The Pazufloxacin STD Group. 1998. Reduced clinical efficacy of pazufloxacin against gonorrhea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. Antimicrob. Agents Chemother. 42:579-582.
10. Tanaka, M., H. Nakayama, M. Haraoka, T. Nagafuji, T. Saika, and I. Kobayashi. 1998. Analysis of quinolone resistance mechanisms in a sparfloxacin-resistant clinical isolate of Neisseria gonorrhoeae. Sex. Transm. Dis. 25:489-493.
11. Tapsall, J. W., E. A. Limnios, C. Thacker, B. Donovan, S. D. Lynch, L. J. Kirby, K. A. Wise, and C. J. Carmody. 1995. High-level quinolone resistance in Neisseria gonorrhoeae: a report of two cases. Sex. Transm. Dis. 22:310-311.