Admixture with whole blood does not explain false-negative urease tests

Journal of Clinical Gastroenterology

Volumn 30, Issue 1, 2000, Pages 64-65

  Perry, Marilyn ^a   Vakil, Nimish ^b   Cutler, Alan F ^a,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c SINAI GRACE HOSPITAL   (United States)

Author keywords

Helicobacter pylori antibody; Helicobacter pylori serology; Rapid urease test

Indexed keywords

REAGENT; UREASE;

ADOLESCENT; ANALYTICAL EQUIPMENT; ARTICLE; BLOOD; CONTAMINATION; CONTROLLED STUDY; DIAGNOSTIC ERROR; DIAGNOSTIC TEST; DIGESTIVE SYSTEM HEMORRHAGE; DILUTION; ENZYME ASSAY; HELICOBACTER PYLORI; HUMAN; PRIORITY JOURNAL;

ENZYME TESTS; FALSE NEGATIVE REACTIONS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; UREASE;

EID: 0033986210     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-200001000-00012     Document Type: Article

References (10)

1. Howden CW. Clinical expressions of Helicobacter pylori infection. Am J Med 1996;100(suppl):27S-34S.
2. Mobley HLT. Defining Helicobacter pylori as a pathogen: strain heterogeneity and virulence. Am J Med 1996;100(suppl):2S-9S.
3. Marshall BJ, Warren JR, Francis GJ, et al. Rapid urease test in the management of Campylobacter pyloridis associated gastritis. Am J Gastroenterol 1987;82:200-10.
4. Langenberg ML, Tytgat GNJ, Schipper MEI. Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet 1984;i:1348.
5. Lai KC, Hui WM, Lam SK. Bleeding ulcers have high false negative rates for antral Helicobacter pylori when tested with urease test [abstract]. Gastroenterology 1996;110:A167.
6. Colin R, Bigard MA, Notteghem B, et al. Poor sensitivity of direct tests for detection of Helicobacter pylori on antral biopsies in bleeding ulcers [abstract]. Gastroenterology 1997;112:A93.
7. Lee JM, Breslin NP, Fallon C, O'Morian CA. The rapid urease test lacks sensitivity in bleeding peptic ulcer disease [abstract]. Gastroenterology 1997; 112:A195.
8. Lee CL, Tu TC, Yang RN, et al. Does blood in the stomach influence the diagnosis of H. pylori infection with bleeding peptic ulcer? Gut 1997;41: A274.
9. Archimandritis A, Tzivras M, Souyioultzis S, et al. High rates of false negative rapid urease test (CLO) in patients with upper gastrointestinal bleeding. Gut 1997;41:A273.
10. Laine L, Sidhom O, Sarvin E, Estrada R, Cohen H. Effect of blood on rapid urease testing of gastric mucosal biopsy specimens. Gastrointest Endosc 1998;47:141-3.